Abstract: Thiazolinone-(2)-carboxylic acid esters having the formula: ##STR1## ARE PREPARED BY REACTING A .beta.-AMINO ACRYLIC ACID ESTER WITH CHLOROCARBOXYL SULPHENYL CHLORIDE (COCl-SCl) at a temperature of from 0.degree. to 200.degree. C. The esters are useful as plant protecting agents such as a fungicide.

Abstract: Novel 2-substituted-5,6-dimethoxyindazoles of the formula: ##STR1## where R is cyclohexyl, phenethyl, phenyl, dimethylamino, aminoalkyl, methoxyethyl, indazolylethyl, tetrahydropyranylmethyl, p-dimethylaminophenyl, 2-hydroxyethyl, allyl, thiazolyl, pyridyl, 2,3-dihydroxypropyl, and hydroxy are useful as central nervous system depressants or hypotensive agents.

Abstract: A compound of the formula: ##STR1## wherein R.sup.1 stands for a halogenoethoxycarbonylamino and R.sup.2 stands for hydrogen or a halogen, is an important intermediate for producing a cephalosporin derivative of the formula: ##STR2## wherein R.sup.3 stands for methyl, acetoxymethyl, carbamoyloxymethyl, an alkoxymethyl, an alkylthiomethyl, 2-carboxy-1-ethenyl, or a heterocyclic thiomethyl, R.sup.5 stands for hydrogen or methoxy and R.sup.2 has the same meaning as defined before, which is active against various pathogenic microorganisms even at a low concentration.

Abstract: Naphthyridinomycin complex, a major component thereof called naphthyridinomycin A and a minor component thereof called naphthyridinomycin B are disclosed. These antibiotic substances exhibit antibacterial activity. The substances are producible by culturing a microorganism of the species Streptomyces in an aqueous nutrient medium under submerged aerobic fermentation conditions. Methods for their preparation and use are included.

Abstract: Nitrosourea derivatives represented by the formula ##STR1## wherein A represents a group of the formula B--Y-- in whichB is an unsaturated 5- or 6-membered heterocyclic group which has the as hetero atom at least one nitrogen atom, an unsaturated 9-membered heterocyclic group which has as the hetero atom at least one nitrogen atom and a bicyclic fused ring or an unsaturated 10-membered heterocyclic group which has as the hetero atom at least one nitrogen atom and a bicyclic fused ring, the heterocyclic groups optionally having alkyl, alkoxy, hydroxyl, amino, hydroxyalkyl or halogen as ring substituent andY represents a group of the formula --(CH.sub.2).sub.m -- in which m is an integer of 1 or 2, the group optionally having alkyl as a substituent;A group of the formula ##STR2## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8 and R.sup.

Abstract: Mono- and dithiophosphonic acid esters of the formula ##STR1## in which R is optionally substituted alkyl, cycloalkyl, cycloalkenyl, or optionally substituted phenyl, R' is optionally substituted alkyl, alkenyl, or cycloalkyl, R" and R'" which are identical or different, are hydrogen, halogen, methyl, methoxy, nitro or trifluoromethyl, and X is oxygen or sulfur, are useful insecticides and acaricides.

Abstract: Dyestuffs of the formula ##STR1## wherein R, R.sub.1, and R.sub.2 represent optionally substituted alkyl groups that can be interrupted by heteroatoms, and also represent cycloalkyl, aralkyl, aryl, or heterocyclic radicals, R and R.sub.1 can also be hydrogen atoms, R.sub.1 and R.sub.2, together with the nitrogen atom, are able to form a 5-membered or 6-membered ring, R and R.sub.2 are able to combine to form a nitrogen-containing heterocycle, B is =O or =NH, and A represents a heterocycle. The new dyestuffs dye synthetic fibers, especially polyester fibers, in greenish yellow shades.

Abstract: Disclosed are novel substituted pyrimidinyloxy-(thio)phenyl ureas and derivatives thereof. The compounds of the instant invention are useful as herbicides and can be formulated to provide herbicidal compositions.

Abstract: New compounds of the formula ##STR1## wherein R.sub.1 and R.sub. 2 each is alkyl; R.sub.3 is a nitrogen-containing heterocyclic group; and R.sub. 4 is optionally substituted phenyl, are useful as herbicides.

Abstract: A new process for preparing 5-oxo-tetrahydroquinolines comprises condensing a compound of formula II with a ##STR1## compound of formula III to obtain a compound of formula I wherein R, R.sup.1, R.sup.2 and R.sup.3 are selected from hydrogen or alkyl, aralkyl or aryl groups, Y is NH.sub.2 or OH accompanied by an ethylenic bond or Y is oxo and the double bond is absent and A is an amino or lower alkoxy group of 1-4 carbon atoms at least one of Y or A being amino. Compounds of formula I are intermediates for pharmaceuticals.

Abstract: A method for the purification of crude 2-aminothiazole comprising subjecting an aqueous melt of crude 2-aminothiazole to a vacuum distillation in the presence of a trialkyl borate and fractional solidification of the ensuing vapors.

Abstract: Dibenzo[b,f]thiepin derivatives of the formula ##SPC1##Wherein R, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as hereinafter set forth, are described. The dibenzo[b,f]thiepins of the invention possess strong central depressant and neuroleptic properties and are therefore useful, for example, in the treatment of acute or chronic schizophrenia and also as tranquilizers.

Abstract: 1-Piperazino-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepines of the formula II: ##SPC1##wherein R is hydrogen, alkyl of 1 to 3 carbon atoms, inclusive, or .beta.-hydroxyethyl; wherein R.sub.1 is hydrogen or alkyl defined as above; and wherein R.sub.2 and R.sub.3 are hydrogen, alkyl as defined above, fluoro, chloro, bromo, nitro or trifluoromethyl, are obtained by reacting a compound of the formula I: ##SPC2##wherein R.sub.1, R.sub.2, and R.sub.3 are defined as above and wherein X is chloro or bromo with a piperazine of the formula: ##SPC3##Wherein R is defined as above.The compounds of the formula II and their pharmacologically acceptable acid addition salts thereof, have tranquilizing, sedative and anti-depressant effects, and are useful for suppression of anxiety and depression in mammals and birds.

Abstract: The invention relates to novel 1-(4-R.sub.1 O-phenyl)-2-(4-R.sub.2 -phenyl)-6-R.sub.3 -1,2,3,4-tetrahydroquinolines having antifertility and hypocholesterolemic activities, to their preparation, and to novel intermediates therefor.

Abstract: New 4-amino derivatives of pyrazolo[1,5-a]quinoxaline-3-carboxylic acid, esters and their salts have the formula ##SPC1##R.sub.1 is hydrogen, lower alkyl or a salt forming ion;R.sub.2 and R.sub.3 each is hydrogen, lower alkyl, cyclolower alkyl, phenyl, substituted phenyl, phenyl-lower alkylene, di-lower alkylamino-lower alkylene or R.sub.2 and R.sub.3 together with the nitrogen form an unsubstituted or substituted 5- or 6-membered nitrogen heterocyclic in which an additional nitrogen or oxygen may be present.R.sub.4 is hydrogen, lower alkyl or halogen.The new compounds are useful as anti-inflammatory agents.

Abstract: The new derivatives of 1,2,4-triazolo[4,3-b]pyridazin-3-ones and their salts which have the general formula ##SPC1##Wherein R.sub.1 represents hydrogen or lower alkyl, and R.sub.2 represents acyclic or cyclic amine groups,Are useful as psychotropic, anti-inflammatory and hypotensive agents.

Abstract: Novel 1,3,4-thiadiazol-2-ylureas characterized by an hetero-ring sulfamoyl group at the 5-position, and by small alkyl or alkoxy groups on the urea nitrogens. The hetero-ring groups are 5- and 6-membered rings containing an oxygen, sulfur, or nitrogen atom, and may optionally be linked to the sulfamoyl nitrogen by a methylene group. The novel compounds are effective pre- and postemergence herbicides.

Abstract: A 2'-halopenicillin compound is prepared from a penicillin-1-oxide compound by the action of an acid halide in the presence of a base. The product on heating rearranges to a 3-halo-3-methylcepham compound which itself gives a 3-methyl-3-cephem compound on further heating. A 2'-halopenicillin compound gives a 3-methyl-3-cephem compound on heating. The 2'-halopenicillin compounds, 3-halo-3-methylcepham compound and 3-methyl-3-cephem compounds are antibacterials which are also useful as intermediates for the synthesis of other penicillins and cephalosporins.

Abstract: Substituted 7,12-methano-dibenzazocines, e.g., 7,13-dihydro-6,12-dimethyl-7,12-methano-6H-dibenz[c,f]azocine, are prepared by cyclizing 3-benzylamino-alkyl-indan-1-ols and are useful as anti-inflammatory agents.

Abstract: 2-Alkylsulfinyl-6-nitrobenzthiazoles of the formula ##SPC1##In which R is alkyl having from 1 to 10 carbon atoms are prepared by reacting 2-alkylmercaptobenzthiazoles of the formula ##SPC2##With at least 2 moles of fuming nitric acid in at least 300 grams of sulfuric acid, of at least 90 % strength, per mole of benzthiazole.