Abstract: Methods of treating non-inflammatory diseases characterized by abnormal calcium and phosphate metabolism comprising administering a pharmaceutical composition comprising a geminal diphosphonic acid compound in which the diphosphonic acid-containing carbon is linker via a sulfur atom or a sulfur-containing chain to a 6-membered aromatic ring containing one or more nitrogen atoms.

Abstract: A topical pharmaceutical formulation, useful as a vehicle for E-type prostaglandins is described.

Abstract: Specific N-methyl-D-aspartate receptor antagonists are useful in the prevention and treatment of neurodegeneration in various pathological states.

Abstract: Dehydrated liposomes are prepared by drying liposome preparations under reduced pressure in the presence of one or more protective sugars, e.g., the disaccharides trehalose and sucrose. Preferably, the protective sugars are present at both the inside and outside surfaces of the liposome membranes. Freezing of the liposome preparation prior to dehydration is optional. Alternatively, the protective sugar can be omitted if: (1) the liposomes are of the type which have multiple lipid layers; (2) the dehydration is done without prior freezing; and (3) the dehydration is performed to an end point which results in sufficient water being left in the preparation (e.g., at least 12 moles water/mole lipid) so that the integrity of a substantial portion of the multiple lipid layers is retained upon rehydration.

Abstract: A composition comprised of non-esterified fatty acids having 14-18 carbon atoms; monoglycerides which are monoesters of glycerol and fatty acids having 14-18 carbon atoms; lysophosphatidyl choline in which the fatty acid moiety has 14-18 carbon atoms and a drug is disclosed. The composition is useful for the delivery of orally-administered drugs. The composition is also useful as a source of readily absorbable fat. When used in this manner, the composition is comprised of non-esterified fatty acids having 14-18 carbon atoms; monoglycerides which are monoesters of glycerol and fatty acids having 14-18 carbon atoms; lysophosphatidyl choline in which the fatty acid moiety has 14-18 carbon atoms. A method of making the compositions disclosed is also described.

Abstract: A method of reducing anemia caused by the administration of 3'-azido-3'-deoxythymidine to an animal which comprises treating said animal with a compound which inhibits the enzyme uridine phosphorylase in order to increase cellular uridine levels is disclosed. A particularly-effective compound is 5-benzylacyclouridine.

Abstract: Pharmaceutical compositions containing unit or separate dosages of 2.5 to 5 grams of reduced glutathione (GSH) and known anti-tumor agents, to be used simultaneously, separately or sequentially in anti-tumor therapy.Compounds of the invention, that can be used both in mono- or polychemotherapy, reach surprising results against tumors, thus avoiding the onset of dangerous side-effects, such as nephrotoxicity induced by cisplatinum, and increasing the long term survival rates.

Abstract: An agent for the treatment of disorders associated with cerebral ischemia which comprises N-(2-hydroxyethyl) nicotinamide nitrate as an active ingredient.

Abstract: 5H-pyrido[2',1':2,3]imidazo[4,5-b]indoles of the formulae ##STR1## their pharmaceutically acceptable acid addition salts and the corresponding compounds bearing one or more halogens and/or lower-alkyl groups on the available ring carbon atoms are administered in cholinomimetic amounts to mammals with low acetylcholine or cholinergic activity to ameliorate the symptoms associated with that condition.

Abstract: A heat activated hair curling treatment composition containing an effective amount of a certain linear or branched or crosslinked water soluble polyethylene oxide polymer having a melting point of 50.degree. to 80.degree. C. and a molecular weight in a range of from 50,000 to 250,000 for the linear polymers and from about 20,000 to 250,000 for the branched or crosslinked polymers. The composition may be formulated into aerosols or pump sprays and facilitates long lasting hair styling without damaging hair. The polymer is exposed to heat from a curling iron which causes it to melt thereby imparting a curl to the hair. The composition is comprised of the polyethylene oxide polymer, optionally, at least one surfactant, and a cosmetically acceptable solvent such as water, ethanol and mixtures thereof.

Abstract: Disclosed are total parenteral nutrition formulations which include essential amino acids in combination with either arginine or ornithine, for use in the detection of recurrent malignant disease in patients. Such formulations stimulate tumor-specific polyamine production to a greater extent than non-tumor related polyamine production. Additionally, such formulations were found to specifically promote an increase in red blood cell putrescine levels of tumor-bearing rats. Nontumor-bearing rats were not found to be similarly reactive to these formulations. Methods for making and administering these formulations as well as their use in preventing DFMO-induced toxicity are also disclosed.

Abstract: A sterilizing and disinfecting solution is disclosed. The solution contains a saturated dialdehyde such as glutaraldehyde and an aromatic dialdehyde, such as phthalaldehyde, isophthalaldehyde or terephthalaldehyde.

Abstract: Disclosed herein is an effective and safe method for preventing the onset of neonatal jaundice through the reduction of bilirubin production. This method can be applied to populations of infants based on mass screening procedures predictive of development of the disease. The most effective of these screening methods measures carbon monoxide production by the infants using a simple breath test.

Abstract: Disclosed are tetraalkyl enthenylidenebisphosphonates and a method for their manufacture. These compounds are suitable for use as antimicrobial agents in combating a number of pathogenic microorganisms, such as bacteria, yeasts, viruses, fungi and protozoa, when used together with a pharmaceutically-acceptable carrier. Also disclosed is a method for treating infectious diseases by administering a safe and effective amount of these tetraalkyl ethenylidenebisphosphonates.

Abstract: This invention relates of the use of a certain thiazolidine-2,4-dione, namely, dl-5-[(2-benzyl-3,4-dihydro-2H-benzopyran-6-yl)methyl]thiazolidine-2,4-dio ne, or a pharmaceutically acceptable cationic salt thereof, for retarding the development of arterial disease in mammals. More specifically, it relates to a method for reducing the serum cholesterol levels in mammals by administering to said mammals dl-5-[(2-benzyl-3,4-dihydro-2H-benzopyran-6-yl)methyl]-thiazolidine-2,4-di one or a pharmaceutically acceptable cationic salt thereof.

Abstract: Wood preservative compositions containing as active ingredients compounds of copper, of chromium and of arsenic are produced by mixing copper arsenate and sodium dichromate in an aqueous medium into which is introduced strong acid, for example sulphuric acid, effective to achieve a soluble product. The acid addition is preferably effective to reduce the pH to below 0. The composition so produced is a homogeneous paste which may be dissolved in water to working concentration and used for the preservation of wood by impregnation techniques.

Abstract: A method of treating or preventing hyperlipemia by administering ethanolamine derivatives. As preferable ethanolamine derivatives are mentioned N-(9,12,15,-octadecatrienoyl)-2-aminoethyl nicotinate, N-(5,8,11,14,17-eicosapentaenoyl)-2-aminoethyl nicotinate and the like. Hyperlipemia is effectively prevented or treated by administering 300-2000 mg per day of said ethanolamine derivative for adults.

Abstract: Hydrosoluble pharmaceutical compositions containing, as the active principal, salts of (-)cis-1,2-epoxypropylphosphonic acid with aminoacids such as arginine, ornithine, lysine, cysteine, and the like, characterized by containing a hydrophyllic organic base.

Abstract: An antifungal vaginal suppository is disclosed comprising cis-2-(1H-imidazolylmethyl)-3-(2',6'-difluorobenzyloxy)-2,3-dihydro-5-fluo robenzo[b]thiophene in a suppository base containing biocompatible polymers, a surfactant and an absorbent in a vegetable oil phase.

Abstract: A dry pesticidal composition of a toxicant having a melting point in a range of from 0.degree. C. to 65.degree. C. (the said range of melting point applies also to the melting point of a mixure of toxicants) containing a hydrocarbon represented by the formula, ##STR1## wherein X.sub.1, X.sub.2, Y.sub.1, Y.sub.2, Z.sub.1 and Z.sub.2, which may be the same or different represent a hydrogen atom or an alkyl group having 2 or less carbon atom, R.sub.1 and R.sub.2, which may be the same or different, represent a hydrogen atom or a methyl group, and n represents 0 or 1.