Patents Examined by Robert A. Wax
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Patent number: 11969426Abstract: The present invention relates to pharmaceutical compositions comprising Akt protein kinase inhibitors with therapeutic activity against diseases such as cancer as well as processes for their preparation and their use as medicament.Type: GrantFiled: April 19, 2022Date of Patent: April 30, 2024Assignee: Genentech, Inc.Inventors: Reinhard Reents, Pirmin Hidber, Andre Hell, Peter Steidle, Martin Wunderlich, Marie Pepelnjak, Francis Gosselin, Edward Yost
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Patent number: 11964054Abstract: Formulations of tegavivint, methods of making such formulations, and methods of treatment of cancer by administering the formulations.Type: GrantFiled: February 6, 2023Date of Patent: April 23, 2024Assignee: Iterion Therapeutics, Inc.Inventors: Gowri Sukumar, Drazen Ostovic
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Patent number: 11964957Abstract: Embodiments provide a pest control agent that is excellent in safety, controlling effect, residual activity, and so on. According to an embodiment, there is provided a pyrazole derivative represented by general formula [I], or an agriculturally acceptable salt thereof, and a pest control agent containing the same as an active ingredient: wherein, p represents an integer of 0 or 1, R1, R2, R3, R4, and R5 represent a hydrogen atom, halogen atom, C1-C6 alkyl group, or the like, A represents an oxygen atom or sulfur atom, Q represents a halogen atom, C6-C10 aryl group that is unsubstituted or substituted with (R8)m, or the like, and R6 and R7 represent a hydrogen atom, C1-C6 alkyl group, or the like.Type: GrantFiled: May 24, 2019Date of Patent: April 23, 2024Assignee: KUMIAI CHEMICAL INDUSTRY CO., LTD.Inventors: Ryo Ishikawa, Akira Kinpara, Keiji Toriyabe, Akira Watanabe, Masao Nakatani, Akira Takanezawa, Takeshi Matsuda
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Patent number: 11957793Abstract: The present invention provides a nanoparticle comprising a poly(alkyl cyanoacrylate) homopolymer, or copolymer, at least one active agent and an anionic and radical inhibitor, wherein the anionic and radical inhibitor is a compound having the following formula: wherein R1 is H; and R3, R4, R5, R6 and R7 are independently selected from the group consisting of —H, —OH, C1-C6 alkoxide, C1-C6 alkyl, halides, carboxylic acid, ketone or aldehyde; wherein the anionic and radical inhibitor is present in an amount of 0.001 to 15 wt %, as well as a process suitable for manufacture of the nanoparticle.Type: GrantFiled: August 23, 2019Date of Patent: April 16, 2024Assignee: SINTEF TTO ASInventors: Ruth Schmid, Peter Molesworth, Yrr Mørch, Einar Sulheim, Heidi Johnsen
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Patent number: 11957644Abstract: A therapeutic composition and a method of producing it by light-activating hypericin in a carrier or solvent. Preferably, the composition is made by combining dried flowers and/or flower stems of St. John's Wort with edible oil and exposing the mixture to the sun for a prolonged time. This process serves to light-activate the hypericin before its use and reduce risk of skin phototoxicity. The composition can be used for treating undesirable conditions such as mouth sores and vaginal infections.Type: GrantFiled: October 5, 2022Date of Patent: April 16, 2024Inventors: Natasa Stojanovic, Robert D. Fish
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Patent number: 11957647Abstract: Disclosed is a pharmaceutically-acceptable composition in the form of a solid, amorphous, mono-particulate powder comprising a mixture of: (a) a pharmacologically-effective dosage amount of an adrenergic receptor modulator, or a pharmaceutically-acceptable salt thereof; and (b) a pharmaceutically-acceptable carrier material, which carrier material comprises a maltodextrin with a dextrose equivalent (DE) that is above 15. Compositions are suitable for transmucosal drug delivery, including nasal delivery, by which said compositions may be loaded into a single-use nasal applicator. Compositions are preferably made by way of spray drying and may further include a disaccharide, such as lactose or trehalose which, along with the active ingredient and maltodextrin, may be spray-dried together in combination. Compositions may further comprise one or more alkyl saccharides. Preferred alkyl saccharides include sucrose esters, such as sucrose monolaurate.Type: GrantFiled: May 24, 2023Date of Patent: April 16, 2024Assignee: OREXO ABInventors: Jonas Sävmarker, Robert Rönn
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Patent number: 11951169Abstract: The present disclosure relates to a pharmaceutical composition having a mixture containing curcuminoids as at least one of the active therapeutic agents. Generally, the mixture comprises 4-8% by weight of purified curcuminoids; 20-35% by weight of an oil phase; 25-35% by weight of a co-solvent; and 40-50% by weight of a surfactant. Preferably, the purified curcuminoids in the mixture has an average size of about 19 nm or at least half of the curcuminoids carried in the mixture has particle size not exceeding 19 nm.Type: GrantFiled: January 8, 2020Date of Patent: April 9, 2024Assignee: AASTAR PTE LTD.Inventor: The Huy Tran
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Patent number: 11944597Abstract: Pharmaceutical compositions comprising an immediate release component comprising 4-((L-valyl)oxy)butanoic acid and a modified release component comprising 4-((L-valyl)oxy)butanoic acid and the pharmacokinetics of 4-((L-valyl)oxy)butanoic acid and ?-hydroxybutyrate following oral administration of the pharmaceutical compositions is disclosed.Type: GrantFiled: October 26, 2022Date of Patent: April 2, 2024Assignee: XWPHARMA LTD.Inventors: Daniel M. Canafax, William W. Xiang, Leonard Blum, Jia-Ning Xiang
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Patent number: 11944091Abstract: The present subject matter relates to a stable pesticidal formulation which exhibits improved dispersibility in cold water and full compatibility with fertilizers.Type: GrantFiled: December 7, 2017Date of Patent: April 2, 2024Assignee: ADAMA MAKHTESHIM LTD.Inventors: Shlomo Levy, Michael Berkovitch, Viacheslav Firer
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Patent number: 11938222Abstract: The present application relates to a pregabalin sustained release composition, comprising: (a) an active ingredient; (b) a matrix-forming agent; (c) a swelling agent; (d) a gelling agent; and optionally a filler. The pregabalin sustained release composition provided in the present application can rapidly swell in volume when exposed to aqueous medium until exceeding the dimeter of human gastric pyloric (13 mm). It thereby prolongs the gastric emptying time to increase the retention time of pregabalin in the stomach and enhances absorption of pregabalin in the small intestine and ascending colon. Moreover, the pregabalin sustained release composition provided herein achieves a sustained release for 24 h, which allows QD (once a day) administration, reduces administration number, and improves patient compliance.Type: GrantFiled: June 12, 2019Date of Patent: March 26, 2024Assignee: BEIJING TIDE PHARMACEUTICAL CO., LTD.Inventors: Zhaolu Zhu, Yun Wu, Di Lu, Yanping Zhao, Liying Zhou, Yanan Liu
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Patent number: 11931379Abstract: Compositions, systems and methods of dispensing compositions for treating skin conditions, the compositions including an inorganic compound and having desirable viscosity, spreadability and foam drainage profiles.Type: GrantFiled: December 6, 2016Date of Patent: March 19, 2024Assignee: Johnson & Johnson Consumer Inc.Inventor: Jiger Patel
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Patent number: 11931455Abstract: Disclosed herein are pharmaceutical compositions in the form of a suspension for oral delivery. Some embodiments provide a pharmaceutical composition in the form of a suspension for oral delivery comprising an active pharmaceutical ingredient; water; a suspending agent; a buffering agent; and one or more of a wetting agent and a binder/filler. In some embodiments, the active pharmaceutical ingredient is selected from quetiapine, sildenafil, tadalafil, cinacalcet, ticagrelor, mycophenolate, aprepitant, zonisamide, and primidone.Type: GrantFiled: July 31, 2023Date of Patent: March 19, 2024Assignee: LIQMEDS WORLDWIDE LIMITEDInventors: Sandip Mehta, Manish Kumar Umrethia, Jayanta Mandal
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Patent number: 11925710Abstract: Pharmaceutical granulations having a functional coating surrounding a core containing 4-((L-valyl)oxy)butanoic acid are disclosed. The functional coatings provide for immediate release or modified release of 4-((L-valyl)oxy)butanoic acid. The pharmaceutical granulations can be used in oral pharmaceutical compositions.Type: GrantFiled: June 17, 2022Date of Patent: March 12, 2024Assignee: XWPHARMA LTD.Inventors: Sami Karaborni, Daniel M. Canafax, Jia-Ning Xiang, William W. Xiang, James Tien, Stefanie Thiel, Norbert Pollinger, Annette Grave
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Patent number: 11925531Abstract: The present disclosure provides a magnetic dressing and a preparation method and use thereof, belonging to the technical field of pharmaceutical preparations. The magnetic dressing includes a magnetic layer, a drug-loading layer, and a protective layer that are stacked in sequence, where the magnetic layer includes polyvinyl alcohol, gluten, and iron particles. In the present disclosure, a swallowed magnetic dressing is controlled by an external magnetic field, and the magnetic dressing is moved to a pathological position by changing a direction of the external magnetic field; after the external magnetic field is removed, the magnetic dressing changes from a ring to a sheet, thereby completing attachment of an entire lesion surface to complete treatment by autonomous drug release.Type: GrantFiled: September 13, 2022Date of Patent: March 12, 2024Assignee: Shanghai UniversityInventors: Na Liu, Ziheng Chen, Huiyu Yuan, Dan Zhang, Kewei Zhang, Tao Yue, Yuanyuan Liu, Yan Peng
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Patent number: 11925731Abstract: Provided are methods, devices and compositions for reducing and/or inhibiting postsurgical tissue adhesion using a hydrogel film disposed onto a target tissue, thereby providing an adhesion barrier that remains over said target tissue for a prescribed period of time. In some embodiments, the hydrogel film is formed by the gelation of a pre-gel mixture applied onto the target tissue as a plurality of particles having an average maximum dimension, such as diameter, of at most about 500 ?m. In some embodiments, the hydrogel film has a minimum storage modulus of 100 Pa. In some embodiments, the pre-gel mixture comprises an ECM digest having a collagen to carbohydrate ratio (by mass) of at least 70:1.Type: GrantFiled: August 26, 2022Date of Patent: March 12, 2024Assignee: TEXAS MEDICAL CENTERInventors: Timothy J. Keane, Jr., Peter Alexander Smith, Stephen G. Ramon
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Patent number: 11918684Abstract: The present invention provides pharmaceutical composition of immunosuppressive agent in oral suspension dosage form. The oral suspension composition comprises of immunosuppressive agent with other pharmaceutical excipients such as vehicle, suspending agent, solvent or cosolvent, preservative, sweetener, antifoaming agent, wetting agent, buffering agent and flavouring agent. The present invention oral suspension having improved stability, palatability with high dose of active ingredient. The present invention provides oral suspension with flavor that has masked bitter taste of the drug and eliminates difficulty of administration. Further, the present invention also provides a convenient, easy process for preparation thereof.Type: GrantFiled: March 12, 2018Date of Patent: March 5, 2024Assignee: LIQMEDS WORLDWIDE LIMITEDInventors: Sandip Mehta, Manish Umrethia, Henil Patel, Jayanta Kumar Mandal
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Patent number: 11918685Abstract: Provided herein are stable amlodipine liquid formulations. Also provided herein are methods of using amlodipine liquid formulations for the treatment of certain diseases including hypertension and Coronary Artery Disease (CAD).Type: GrantFiled: May 30, 2023Date of Patent: March 5, 2024Assignee: AZURITY PHARMACEUTICALS, INC.Inventors: Scott Brauer, Gerold L. Mosher
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Patent number: 11910798Abstract: Embodiments of the present disclosure, in one aspect, relate to compositions including a vacancy-engineered (VE)-ZnO nanocomposite, methods of making a composition, methods of using a composition, and the like.Type: GrantFiled: November 25, 2022Date of Patent: February 27, 2024Assignee: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.Inventors: Swadeshmukul Santra, Megan Berroth
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Patent number: 11911347Abstract: The present invention is in the field of antioxidants and relates to cosmetic or pharmaceutical, preferably dermatological, compositions or homecare product comprising or consisting of a synergistic combination of a specific antioxidant and an effective amount of 1,2-heptanediol and/or 2,3-heptanediol or of a specific alkanediol or a mixture of two or more different specific alkanediols and the use of said compositions as a cosmetic, for personal care, as a pharmaceutical or homecare product, in particular for scavenging reactive oxygen species (ROS), for inhibition matrix metalloproteinases expression and/or for inhibiting interleukin 8 (IL-8) secretion.Type: GrantFiled: April 14, 2023Date of Patent: February 27, 2024Assignee: Symrise AGInventors: Nikolas Bugdahn, Sven Siegel, Sabine Lange, Dominik Stuhlmann
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Patent number: 11903951Abstract: Described herein are nasal pharmaceutical compositions comprising a porous excipient and an active agent, wherein the active agent is loaded onto a surface of the porous excipient located inside pores of the porous excipient, and wherein the composition is adapted for nasal administration. Also described herein are methods of making and using nasal pharmaceutical compositions.Type: GrantFiled: June 2, 2017Date of Patent: February 20, 2024Assignee: M et P Pharma AGInventor: Claudia Mattern