Abstract: Invention concerns 4,5-bisubstituted-2-imidazolone derivatives of formula I ##STR1## and pharmaceutically acceptable salts thereof, having high affinity in vitro for D.sub.2, 5-HT.sub.2, .sub.1 receptors and in vivo activity on central nervous system and antihypertensive activity with negligible secondary effects; methods for the preparation thereof; pharmaceutical formulations containing them.

Abstract: A substituted phenylalkylimidazole compound of the formula: ##STR1## wherein R is an alkyl group or an alkenyl group, X is a halogen atom, a methyl group, a methoxy group, a phenoxy group, a trifluoromethyl group or a dimethylamino group, and n is an integer of 1 or 2.

Abstract: The present invention provides an indolenine derivative represented by the formula ##STR1## wherein R.sup.1 is a hydrogen atom or a lower alkyl group, X and Y are the same or different and each represent a methylene group or an oxygen atom. This indolenine derivative is useful as an intermediate for synthesizing a cyanine compound suitable for use as an organic near infrared light-absorbing dye useful as an optical disc recording medium adapted for semiconductor laser recording.

Abstract: Substituted 2,3,4,9-tetrahydro-1H-carbazole-1-acetic acid derivatives and methods for their preparation and use are disclosed. The compounds are useful anti-inflammatory agents.

Abstract: N-benzylpiperidineisoindolinones, which have activity as Class III antiarrhythmic agents, acting by prolonging cardiac action potential repolarization. The invention further provides for compositions incorporating the compounds and methods of their use, as well as providing for pharmaceutically acceptable salts of the compounds.

Abstract: The present invention relates to a novel antioxidant-peroxide compound of Structure A,(Y--[R--OO--X).sub.x --An].sub.y Ain which the definitions of X, Y, R, An, x, and y are given in the Summary of the Invention section, for example, t-butyl peroxy-3-(3,5-di-t-butyl-4-hydroxypheneyl) propionate, processes for producing polymeric composition of enhanced oxidative stability via initiation of polymerization of ethylenically unsaturated monomers, curing of elastomers and unsaturated polyester resins, modification of polypropylene and other polymers and copolymers, and crosslinking of olefin polymers and copolymers, and the resulting polymers having enhanced oxidative stability.

Abstract: The present invention relates to pyrrolidine derivatives of the formula ##STR1## wherein R.sup.1 and R.sup.2 are defined as herein. The compounds are useful as anti-amnestic agent.

Abstract: Allylaminoethyltriazoles of the formula: ##STR1## in which R is a hydrogen atom or an alkyl group containing 1 to 5 carbon atoms; each of Ar and Ar' is an unsubstituted phenyl group, a phenyl group substituted by one or more substituents selected from C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy, nitro and halogen, an unsubstituted thienyl group, or a thienyl group substituted by halogen or naphthyl; phytophysiologically or pharmacologically tolerated acid addition salts thereof; and fungicidal and antimycotic agents containing such compounds.

Abstract: This invention provides a series of novel cyclic amides of formula I in which the group >Z--Y--X< is selected from >C.dbd.CH--N<, >N-CH.dbd.CH<, >C.dbd.N--N< and >N--N.dbd.C< and the other radicals have the meanings defined in the following specification. The compounds of formula I are leukotriene antagonists. The invention also provides pharmaceutically acceptable salts of the formula I compounds; pharmaceutical compositions containing the formula I compound, or their salts, for use in the treatment of, for example, allergic or inflammatory diseases, or endotoxic or traumatic shock conditions; and processs for the manufacture of the formula I compounds, as well as intermediates for use in such manufacture.

Abstract: Azole compounds including azoles and azolium salts, and their use as transglutaminase inhibitors are disclosed.

Abstract: The invention relates to novel compounds which are suited for the production of multilayer films which have piezoelectric, and pyroelectric properties, and which provide second harmonic generation. The novel compounds are amphiphilic and it is possible to prepare from same polar single-layer and multi-layer films by depositing them on a substrate. When such substrate is a solid support, polar Z-type Langmuir-Blodgett films are obtained. Upon compression of films of such compounds, at an air/water interface, stable Langmuir monolayers are formed.

Abstract: 4-Chloropyrazoles of the general formula I ##STR1## where R.sup.1, R.sup.2 and R.sup.3 are each independently of the others hydrogen or a radical which is inert under the reaction conditions, are prepared by reacting pyrazoles of the general formula II ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3 are each as defined above, with 0.95-10 equivalents of hypochloric acid, or salts thereof, in the substantial absence of any carboxylic acid.

Abstract: Pyrimidines of the formula I ##STR1## in which R is an alkyl gorup of 1-15 C atoms in which in addition one or two nonadjacent Ch.sub.2 groups can be replaced by --0--, --CO--, --O--CO--, --CO--O--, --CHY-- and/or --CH.dbd.CH--, or is H, F, Cl or CN,X is --O--CH.sub.2 --R.sup.1, --S--R.sup.2, --NCS or --COO--A--R.sup.3,Y is halogen, CN or OH,R.sup.1 is an alkyl group of 1-15 C atoms, in which one or more nonadjacent CH.sub.2 groups are replaced by --O--, --CO--, --0--CO--, --CO--O--, --CHY-- and/or by --CH.dbd.CH--,R.sup.2 is an alkyl group of 1-15 C atoms, in which in addition one or two nonadjacent CH.sub.2 groups can be replaced by --O--, --CO--, --O--CO--, --CO--O--, --CHY-- and/or --CH.dbd.CH--,A is a trans-1,4-cyclohexylene group which is unsubstituted or monosubstituted or disubstituted by F and/or Cl atoms and/or CH.sub.3 groups and/or CN groups, or is a single bond, andR.sup.3 is an alkyl group of 1-15 C atoms, in which in addition ne or two nonadjacent and, if A is a single bond, nonterminal CH.sub.

Abstract: A compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1##

Abstract: A process for preparing 2,6-dimethylphenylisothiocyanate comprises the steps of dissolving 2,6-dimethylaniline in carbon disulfide and ammonium hydroxide to form a dithiocarbamate salt. The salt is reacted with ethyl chloroformate to form 2,6-dimethylphenylisothiocyanate, which may thereafter be reacted with 3-amino-1-propanol and subsequently cyclized, by treating with hydrochloric acid, to form xylazine.

Abstract: Catalytic processes for the synthesis of thionocarbamates by contacting xanthates, and amines, especially primary amines in the presence of at least one suitable catalyst. Suitable catalysts for these processes include finely divided metallic catalysts such as suspended nickel and precious metal(s); for example, Raney Nickel or platinum/palladium on carbon support. Reaction is carried out at a most preferred temperature of from about 70.degree. C. to about 80.degree. C. and for about 8 hours to about 12 hours for example.

Abstract: Novel O-alkylated oximes of the general formula I ##STR1## wherein R.sup.1 and R.sup.2 are optionally substituted aromatic or heteroaromatic rings, R.sup.3 is hydrogen or lower alkyl, R.sup.4 is a nitrogen containing, substituted ring or an amino group carrying a substituted ring, and n and m independently are 0, 1 or 2, are potent inhibitors of GABA reuptake from the synaptic cleft.

Abstract: The invention relates to compounds of the formula: ##STR1## in which: Ar represents a phenyl group substituted by R.sub.2, R.sub.3 and R.sub.4, or a naphth-1-yl or naphth-2-yl group, unsubstituted or substituted by 1 or 2 halogen atoms;X represents an oxygen atom or a sulfur atom;R.sub.1 represents H or a halogen atom;R.sub.2 represents a halogen atom, a trifluoromethyl group, a phenyl group which is unsubstituted by 1 or 3 halogen atoms, a benzyl group which is unsubstituted or substituted by 1 to 3 halogen atoms, a phenoxy group which is unsubstituted or substituted by 1 to 3 halogen atoms, or a C.sub.1 -C.sub.4 alkyl group;R.sub.3 and R.sub.4 represents H, a halogen atom or a C.sub.1 -C.sub.4 alkyl group; andthe benzyl group substitutes the piperidino radical in the 2-, 3- or 4-position,and their salts with mineral or organic acids.

Abstract: The invention relates to compounds of general formula: ##STR1## in which A, B, G, D which may be identical or different, each denote a hydrogen atom or a halogen atom, a lower alkoxy group or alternatively a lower alkyl group optionally substituted with one or more halogen atoms,X denotes a hydrogen atom, a linear or branched lower alkyl group or a group SO.sub.2 E in which E denotes a linear or branched lower alkyl group or an aryl group optionally substituted with a linear or branched lower alkyl group,T denotes a hydrogen atom or a lower alkyl group,R.sub.3 denotes a hydrogen atom or a linear or branched lower alkyl group or an aryl group optionally substituted with one or more linear or branched lower alkyl groups,n and m, which may be identical or different, each denote 0 or 1,R.sub.1 and R.sub.2, which may be identical or different, each denote a hydrogen atom or a linear or branched lower alkyl group,or alternatively,R.sup.1 and R.sup.

Abstract: There are provided certain 13-halo-23-imino-LL-F28249 compounds which are useful for controlling endo- and ectoparasites, insects, acarids and nematodes.