Abstract: A device for driving and guiding a rapier of a weaving machine, comprises a rotatable drive wheel (1) provided for driving a rapier rod (14) in a back and forth movement and a guide channel formed by adjustable guide bodies (10), (11) in order to guide the said rapier rod (14) according to a guide path in co-operation with the drive wheel (1). The guide bodies (10), (11) are part of a guide unit (9) which, as a whole, is adjustable in order to modify the distance between the guide path and the rotation shaft (2) of the drive wheel (1), and where the drive wheel (1) is continuously adjustable in the longitudinal direction of its shaft (2). With this device the clearances of the rapier rod with respect to the drive wheel can be performed easily, rapidly and with great precision, so that this device is able to work with a minimum development of heat and wear.