Patents Examined by Ronald D. Schwadron
  • Methods for producing antibody libraries using universal or randomized immunoglobulin light chains
    Patent number: 7067284
    Abstract: The present invention describes methods for producing antibody libraries, and particularly for increasing antibody library diversity by inducing mutagenesis within the CDR regions of immunoglobulin heavy or light chains that are displayed on the surface of filamentous phage particles comprising the library. The invention also describes oligonucleotides useful for increasing the library diversity, and universal light chains useful in the library production methods.
    Type: Grant
    Filed: July 5, 2000
    Date of Patent: June 27, 2006
    Assignee: The Scripps Research Institute
    Inventors: Carlos F. Barbas, Dennis R. Burton, Richard A. Lerner