Abstract: A physiological pressure transducer is disclosed which can be adapted for multiple uses and which employs a low cost semiconductor strain gauge sensor. The transducer is connected to a fluid-filled catheter/manometer system for measuring pressures inside a living body in areas of medical interest such as the heart, brain, uterus, or the vascular system. The catheter is coupled to the pressure transducer through a unique, disposable dome containing a shaped, compliant isolation media which is in intimate contact with the transducer diaphragm. The complete assembly is adapted for use with standard catheter flushing solutions and flush devices. An improved method of drawing blood samples by using the features of the assembly is also described.