Abstract: The present disclosure describes compositions of matter comprising a ribonucleoprotein complex comprising a nucleic acid-guided nuclease and a guide RNA, and further comprising a blocking nucleic acid molecule represented by Formula IV, wherein Formula IV in the 5?-to-3? direction comprises: T-D-M-A-Lp-C; wherein T is 17-31 nucleotides in length; D is 0-15 nucleotides in length; M is 1-25 nucleotides in length; A is 0-15 nucleotides in length and comprises a sequence complementary to D; and L is 3-25 nucleotides in length; p is 0 or 1; C is 4-15 nucleotides in length and comprises a sequence complementary to T; and wherein the blocking nucleic acid molecule comprises a sequence complementary to a gRNA.

Abstract: A method and apparatus for a treadmill having a frameless treadbase. The treadmill is lightweight and inexpensive. A preferred embodiment features an arched deck. The arched deck has a first end, a second end, and an intermediate portion, wherein the intermediate portion is has an upward incline or convex arch. The arched deck provides intrinsic cushion and incline. The arched deck maintains a convex arch independent of any structure in the treadmill. Additionally, the arched deck is connected to a front support and a rear support, the front support being independent from the rear support.

Abstract: An infant exerciser includes a base plate, a turntable rotatably coupled to the base plate, and a mounting plate removably coupled to the turntable. A chair support assembly is coupled to the mounting plate. The chair support assembly receives a chair to couple the chair to the mounting plate. A foot actuating assembly is coupled to the mounting plate and is positioned adjacent the chair support assembly. The foot actuating assembly has a platform member for being actuated by feet of the infant when the infant is seated in the chair. A drive assembly is coupled to the mounting plate such that the foot actuating assembly is positioned between the chair support assembly and the drive assembly. The drive assembly is actuatable by the platform member and engages the base plate such that actuation of the drive assembly rotates the turntable with respect to the base plate.

Abstract: A magnetic damping device installed in an exercising machine and controlled to impart a magnetic damping force to a load wheel, including two magnetic members symmetrically pivoted to the exercising machine and moved one after the other with an adjustment device relative to the load wheel, and two tensile springs respectively connected between the exercising machine and the magnetic members to provide the magnetic members with different moment of force.

Abstract: An exercise apparatus includes a base having a support stand upstanding therefrom. A pair of spaced apart foot rails each have a first end and opposing second end. The second end of each foot rail rests on the base of the frame. A pair of stroke rails each have a first end and an opposing second end. The first end of each stroke rail is slidably attached to the support stand of the frame while the second end of each stroke rail is hingedly attached to a corresponding foot rail. An axle of a crank is rotatably mounted to the support stand. A pair of crank arms each orthogonally project from the corresponding ends of the axle in opposing directions. Each remote end of the crank arm is rotatably mounted to a corresponding stroke rail between the ends thereof.

Abstract: A foldable shelter has a framework with two major joints. A plurality of rib members, each of generally U-shaped configuration, is attached by the free ends of each rib member being connected at one of the major joints and the other free end being connected at the other major joint. A flexible cover is connected to the ribs and a clamp is coupled to each of the major joints for permitting the releasable attachment of the shelter to the framework of a lounge. The clamps are mounted rotatably with respect to the rib members and include wire springs which are pivotally mounted at respective joints. The axes of each of the respective joints intersect an axis of one of the major joints.

Abstract: This invention relates to an improved free-standing tent frame having at least three four-sided collapsible subframes linked together in side-by-side relation and angled relative to one another so as to stand alone while leaving a gap between the endmost subframes, and a triangularly-segmented roof frame having one more triangular segment than there are subframes in the wall structure. The invention is also characterized by a hub assembly for the subframes of the wall assembly that comprises a series of three or more strut-receiving socket subassemblies hingedly interconnected to produce a closed polygon in which those having four or more sides are self-adjusting to accommodate various included angles between adjacent struts without the latter having to bow or bend.