Patents Examined by Sarada Prasad
  • Chemokine binding protein and methods of use therefor
    Patent number: 6495515
    Abstract: The present invention provides a method of use for a novel type I chemokine binding protein encoded by poxviruses and having amino acid sequence homology with the myxoma virus T7 interferon-&ggr; receptor homolog against disease syndromes associated with acute or chronic dysregulated inflammatory responses.
    Type: Grant
    Filed: September 14, 1999
    Date of Patent: December 17, 2002
    Assignee: Viron Therapeutics, Inc.
    Inventors: Grant McFadden, Alexandra Lucas
  • Antagonists of interleukin-15
    Patent number: 6451308
    Abstract: Disclosed herein are mutant IL-15 polypeptides and methods for using these polypeptides to modulate the immune response in a patient.
    Type: Grant
    Filed: November 9, 1999
    Date of Patent: September 17, 2002
    Assignee: Beth Israel Deaconess Medical Center
    Inventors: Terry B. Strom, Wlodzimierz Maslinski
  • Modulating Th2 cell levels via vMIP-I/CCR8 interaction
    Patent number: 6416954
    Abstract: The present invention relates to the agonist properties of vMIP-I for the chemokine receptor CCR8 as expressed on Th2 cells. Methods of modulating a physiological signal specific to Th2 cells comprising contacting these cells with vMIP-I, agonists and antagonists thereof are disclosed. Methods for treating disease using CCR8 antagonists are also provided. The modulation of the Th2 cell populations through the vMIP-I/CCR8 interaction provides a new means for diagnosing and treating specific disease states and immunologic conditions.
    Type: Grant
    Filed: February 3, 2000
    Date of Patent: July 9, 2002
    Assignee: Schering Corporation
    Inventor: Joseph A. Hedrick