Abstract: A metabolite material of propionibacteria is added to a food product to inhibit the growth of yeast. The metabolite material is produced by growing propionibacteria cells in a liquid growth medium to produce a mixture containing the metabolite material. The mixture can be concentrated and added to a food product as a concentrated liquid or powder. The metabolite material added to a food product may contain viable cells of propionibacteria.
Type:
Grant
Filed:
March 16, 1992
Date of Patent:
November 9, 1993
Assignee:
The State of Oregon Acting by and through the State Board of Higher Education on Behalf of Oregon State University
Inventors:
James W. Ayres, William E. Sandine, George H. Weber
Abstract: The compound (-)-N-t-butyl-4,4-diphenyl-2-cyclopentenylamine, or its hydrochloride salt has anticholinergic activity, and thus has a variety of pharmaceutical utilities.
Abstract: A method of imaging a corporeal situs by radiological techniques, comprising delivery to the corporeal situs of an imagingly effectively amount of a physiologically acceptable composition comprising a boron reagent. A variety of illustrative boron reagents is described, including iodinated boron salts, and boron-containing cyclophosphazene and polyphosphazene reagents having radiopaque character. The reagents and method of the present invention may be employed for a wide variety of radiological imaging applications, e.g., excretory urography, angiocardiography, and aortography.
Abstract: Method for the synthesis of sulfonylimidides having the formula M((RSO.sub.2).sub.2 N).sub.y, wherein M is a metal or an ammonium radical quaternary or not, the Rs, which may be identical or similar are organic monovalent radicals, particularly hydrocarbyles and preferably perfluorohydrocarbyles, in C.sub.1 to C.sub.12, and y is the valence of M. On the one hand, silazane component selected amongst the silazane compounds M(((R.sub.2).sub.3 Si).sub.2 N).sub.y or the associations of a silazane derivative A((R.sub.2).sub.3 Si).sub.2 N or a fluoride M.sub.1 F.sub.z of low cross-linking energy is reacted with, on the other hand, at least one sulfonic halogenite component consisting of a sulfonyl fluoride RSO.sub.2 F or in the association of a sulfonyl chloride RSO.sub.2 Cl with a fluoride M.sub.1 F.sub.z, M, R and y having the above-mentioned significations, M being selected amongst the Ms and being optionally identical to M, z being the valence of M.sub.1 and R.sub.2 representing an alkyl in C.sub.1 to C.sub.4.
Type:
Grant
Filed:
January 5, 1993
Date of Patent:
October 26, 1993
Assignees:
Societe Nationale Elf Aquitaine, Hydro-Quebec
Abstract: A process for producing an ethylenamine, which comprises reacting ammonia and/or an ethylenamine with an ethanolamine in the presence of hydrogen to obtain an ethylenamine having an increased number of ethylene chains over the ammonia and/or the ethyelenamine used as the starting material, wherein a catalyst comprising Ni and M elements wherein M is at least one rare earth element selected from the group consisting of scandium, yttrium, praseodymium, neodymium, samarium, europium, gadolinium, terbium, dysprosium, holmium, erbium, thulium, ytterbium and lutetium, is used for the reaction.
Abstract: Di-(4-aminocyclohexyl)-methane containing 15 to 25% by weight of the trans-trans isomer can be obtained by the catalytic hydrogenation of di-(4-aminophenyl)-methane at elevated temperature and elevated hydrogen pressure in the presence of a ruthenium-containing supported catalyst containing 0.05 to 5% by weight ruthenium on an Al.sub.2 O.sub.3 support which has been treated with compounds of rare earth metals and manganese.
Type:
Grant
Filed:
January 14, 1993
Date of Patent:
September 14, 1993
Assignee:
Bayer Aktiengesellschaft
Inventors:
Otto Immel, Gerhard Darsow, Rudolf Braden, Hans-Helmut Schwarz, Helmut Waldmann
Abstract: A diluent for perfluorocarbons used for retinal unfolding (unfolding PFCL), consisting of a perfluorocarbon (diluent PFCL), which has a low viscosity and is volatile at room temperature, with a boiling point between body temperature (about 38.degree. C.) and 100.degree. C., for removing residual quantities of unfolding PFCL from the eye after performance of a retinal unfolding treatment. A method of treatment consisting of introducing into an eye the above diluent for the above purpose.
Type:
Grant
Filed:
January 24, 1992
Date of Patent:
September 14, 1993
Assignee:
Adatomed Pharmazeutische und Medizintechnische Gesellschaft mbH
Abstract: The invention concerns compounds having the formula I ##STR1## wherein Ar is a phenyl or benzyl group which is optionally substituted with hydroxy or alkoxy;R.sup.1 is hydrogen, lower alkyl, lower alkoxy, hydroxy;R.sup.2 is hydrogen, lower alkyl;R.sup.3 is NR.sup.4 R.sup.5, whereinR.sup.4 and R.sup.5 which can be the same or different, are lower alkyl, or wherein R.sup.4 and R.sup.5, when taken together, form a ring with the nitrogen atom, whereby said ring optionally is substituted with lower alkyl;n is 0 or 1;m is 2 or 3 andtheir salts with physiologically acceptable acids and when the compounds can be in form of optical isomers, the racemic mixture and the individual isomers, for the treatment of disorders of the urinary bladder.
Abstract: This invention provides a method of altering the metabolism of sphingolipids in a cell comprising contacting the cell with a fumonisin, or an analog thereof. The invention also provides a method of detecting the consumption of a fumonisin or a fumonisin analog in a subject comprising (A) detecting, in a sample from the subject, the state of the metabolic pathway of sphingolipids and (B) comparing the state of the metabolic pathway to that of a normal subject, the presence of a change in the state of the metabolic pathway indicating the consumption of a fumonisin or a fumonisin analog. Also provided is a method of detecting the presence of a fumonisin or fumonisin analog contamination in a sample from a food or feed comprising detecting a reaction of the metabolic pathway of sphingolipids, the presence of the reaction indicating the presence of a fumonisin or fumonisin analog contamination. Furthermore, novel fumonisin analogs and compositions comprising fumonisins and fumonisin analogs are provided.
Type:
Grant
Filed:
August 5, 1991
Date of Patent:
August 3, 1993
Assignees:
Emory University, The United States of America as represented by the Secretary of Agriculture
Inventors:
Alfred H. Merrill, Jr., Elaine W. Wang, Dennis C. Liotta, Ronald T. Riley
Abstract: Process for the preparation of saturated primary fatty amines by hydrogenation of the corresponding unsaturated primary fatty aminesIn the novel process, the hydrogenation of the double bonds in an unsaturated primary fatty amine is achieved by reaction of the unsaturated primary fatty amine with hydrogen at a temperature of 80.degree. to 160.degree. C. and a pressure of 1 to 40 bar in the liquid phase and in the presence of 0.1 to 10% by weight of a nickel catalyst or cobalt catalyst. If the fatty amine to be hydrogenated contains ammonia, the latter is substantially removed before the hydrogenation process.
Type:
Grant
Filed:
December 12, 1991
Date of Patent:
July 27, 1993
Assignee:
Hoechst Aktiengesellschaft
Inventors:
Anton Fruth, Julius Strauss, Herbert Stuhler
Abstract: The present invention discloses pesticidally active compounds of formula (II) ##STR1## or a salt thereof, wherein Q is a monocylcic aromatic ring, or fused bicyclic ring system of which at least one ring is aromatic containing 9 or 10 atoms of which one may be nitrogen and the rest carbon each ring system being optionally substituted, or Q is a dihalovinyl group or a group R.sup.6 --C.tbd.C-- where R.sup.6 is C.sub.1-4 alkyl, tri C.sub.1-4 alkylsilyl, halogen or hydrogen; R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are the same or different with at least one being hydrogen and the others being independently selected from hydrogen, halo, C.sub.1-4 alkyl or C.sub.1-4 haloalkyl; and R.sup.1 is selected from hydrogen and C.sub.1-8 hydrocarbyl optionally substituted by dioxalanyl, halo, cyano, trifluoromethyl, trifluoromethylthio or C.sub.1-6 alkoxy and X.sup.1 is hydrogen, fluoro or chloro.
Type:
Grant
Filed:
February 14, 1992
Date of Patent:
July 20, 1993
Assignee:
The Wellcome Foundation Limited
Inventors:
Robert J. Blade, George S. Cockerill, John E. Robinson
Abstract: A process for decolorizing polyalkylene polyamines, which comprises contacting one or more polyalkylene polyamines having an average molecular weight of greater than about 200 and less than about 1000 with carbon at a temperature greater than or equal to about 100.degree. C. and less than or equal to about 300.degree. C. under conditions effective to reduce the color rating of the one or more polyalkylene polyamines.
Abstract: A continuous method of preparing N-monoalkyl alkylenediamines, uncontaminated by the N,N'-dialkyl alkylenediamine, is based on the observation that the disubstituted material selectively precipitates from aqueous media. A scheme is presented where an aqueous alkylenediamine is reacted with a suitable carbonyl component and hydrogen over a supported platinum catalyst. Where the alkylenediamine forms an azeotrope with water it can be conveniently recycled to the reactor.
Abstract: This invention relates to a process for making amines by condensing an amino compound in the presence of a Group VIB metal-containing condensation catalyst. This invention also relates to an alkyleneamines producers composition rich in triethylenetetramine (TETA), tetraethylenepentamine (TEPA) and pentaethylenehexamine (PEHA).
Type:
Grant
Filed:
August 26, 1992
Date of Patent:
July 6, 1993
Assignee:
Union Carbide Chemicals & Plastics Technology Corporation
Inventors:
Stephen W. King, Arthur R. Doumaux, Jr., David J. Schreck
Abstract: A process for increasing the rate of catalytic hydrogenation of aromatic amines by reacting aromatic amines with hydrogen in the presence of a noble metal catalyst, an organic solvent or a mixture of solvents, and at least one salt of a transition or lanthanide metal as a promoter, in an effective amount to increase the rate of the hydrogenation reaction, decrease the induction period, and decrease the amount of higher boiler by-products.
Abstract: A novel cyclobutenedione derivative is provided, represented by formula (I): ##STR1## wherein Ar represents ##STR2## wherein R.sub.1 represents a CH.sub.3 group or a C.sub.2 H.sub.5 group; R.sub.2 represents a C.sub.2 H.sub.5 group, a C.sub.3 H.sub.7 group, a HOC.sub.2 H.sub.4 group, a CH.sub.3 OC.sub.2 H.sub.4 group or a CH.sub.3 group; R.sub.3 represents an alkyl group; Z represents O or S; and R.sub.4 and R.sub.5 each represents an alkyl group, and R.sub.0 represents ##STR3## wherein C* represents an asymmetric carbon atom. A process for preparing a cyclobutenedione derivative represented by formula (I) which comprises reacting a cyclobutenedione derivative represented by formula (II) with an amino acid derivative represented by formula (III): ##STR4## wherein Ar represents ##STR5## wherein R.sub.1 represents a CH.sub.3 group or a C.sub.2 H.sub.5 group, R.sub.2 represents a C.sub.2 H.sub.5 group, a C.sub.3 H.sub.7 group, a HOC.sub.2 H.sub.4 group, a CH.sub.3 OC.sub.2 H.sub.4 group or a CH.sub.3 group; R.
Abstract: A process for the production of a modified H-mordenite which comprises bringing an alkali metal or alkaline earth metal-type mordenite into contact with SiCl.sub.4 under a heating condition and then converting the treated mordenite into an H-type via ion exchange, a catalyst comprising the modified H-mordenite and a process for the production of methylamines using the use of the catalyst.
Abstract: The bis-homotris compounds 4-amino-4-[1-(3-hydroxy-propyl)]-1,7-heptanediol and 4-[1-(3-aminopropyl)]-4-[1-(3-hydroxypropyl)]-1, 7-heptanediol, and organic synthetic methods for their preparation are described. Unique multifunctional aminotriols, as well as their percursors, quaternary nitroalkanes are disclosed as building blocks for unimolecular micelles, as well as new series of cascade polymers. The quaternary nitro compounds which are disclosed allow the synthesis of a new aminotriol containing a quaternary carbon.
Type:
Grant
Filed:
March 9, 1992
Date of Patent:
May 11, 1993
Assignee:
University of South Florida
Inventors:
George R. Newkome, Charles N. Moorefield
Abstract: The bis-homotris compounds 4-amino-4-[1-(3-hydroxypropyl)]-1,7-heptanediol and 4-[1-(3-aminopropyl)]-4-[1-(3-hydroxypropyl)]-1, 7-heptanediol, and organic synthetic methods for their preparation are described. Unique multifunctional aminotriols, as well as their percursors, quaternary nitroalkanes are disclosed as building blocks for unimolecular micelles, as well as new series of cascade polymers. The quaternary nitro compounds which are disclosed allow the synthesis of a new aminotriol containing a quaternary carbon.
Type:
Grant
Filed:
April 14, 1992
Date of Patent:
April 27, 1993
Assignee:
University of South Florida
Inventors:
George R. Newkome, Charles N. Moorefield
Abstract: Compounds of the general formula: ##STR1## (wherein R represents --CH(CH.sub.2 OH).sub.2 or --CH.sub.2 CH(OH)CH.sub.2 OH) possess a package of favorable parameters which render them of particular use not only in all forms of intravascular visualization but also in myelography.The compounds are prepared by reaction of the corresponding 5-monoacetylamino compound with one or more reagents effective to introduce the 2-hydroxy-3-methoxypropyl group.