Patents Examined by Shawquia E Young
  • Indole derivative having I?B kinase ? inhibitory activity
    Patent number: 8193237
    Abstract: Disclosed is a compound represented by the general formula (1) or a salt thereof. The compound or a salt thereof has an inhibitory activity on IKK? and is therefore useful as preventive and/or therapeutic agent for a disease associated with IKK?. In the formula, R1 represents a hydrogen atom, a lower alkyl group, an aryl group, a hydroxy group, or the like; R2 represents a halogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, or the like; and m represents 0, 1, 2, or the like.
    Type: Grant
    Filed: January 15, 2008
    Date of Patent: June 5, 2012
    Assignee: Santen Pharmaceutical Co., Ltd.
    Inventors: Hiroshi Enomoto, Kenji Kawashima, Kazuhiro Kudou, Minoru Yamamoto, Masaaki Murai, Takaaki Inaba, Noriko Ishizaka
  • L-DOPA amide derivatives and uses thereof
    Patent number: 8048926
    Abstract: L-DOPA amide derivatives, pharmaceutical compositions containing same and their use in the treatment of conditions associated with impaired dopaminergic activity/signaling (e.g., Parkinson disease) are disclosed.
    Type: Grant
    Filed: August 4, 2005
    Date of Patent: November 1, 2011
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventor: Daphne Atlas
  • (Aza)indole derivative and use thereof for medical purposes
    Patent number: 8003647
    Abstract: The present invention provides compounds useful as agents for the prevention or treatment of a disease associated with abnormal serum uric acid level which has a uricosuric activity or the like. The present invention relates to (aza)indole derivatives represented by the following general formula (I) having xanthine oxidase inhibitory activities and useful as agents for the prevention or treatment of a disease associated with abnormality of serum uric acid level, prodrugs thereof, or salts thereof.
    Type: Grant
    Filed: April 10, 2008
    Date of Patent: August 23, 2011
    Assignee: Kissei Pharmaceutical Co., Ltd.
    Inventors: Kazuo Shimizu, Yasushi Takigawa, Hideki Fujikura, Masato Iizuka, Masahiro Hiratochi, Norihiko Kikuchi
  • Cycloalkane-substituted pyrazoline derivatives, their preparation and use as medicaments
    Patent number: 7994200
    Abstract: The present invention relates to Cycloalkane-substituted substituted pyrazoline compounds of formula (I), methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals.
    Type: Grant
    Filed: July 17, 2006
    Date of Patent: August 9, 2011
    Assignee: Laboratorios del Dr. Esteve, S.A.
    Inventors: Antonio Torrens Jover, Susana Yenes Minguez
  • Process for making salts of N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide
    Patent number: 7989639
    Abstract: Salts of N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide are prepared by various methods.
    Type: Grant
    Filed: June 7, 2007
    Date of Patent: August 2, 2011
    Assignee: Novartis AG
    Inventors: Joginder S. Bajwa, David John Parker, Joel Slade
  • Functionalized diarylisoxazoles inhibitors of ciclooxygenase
    Patent number: 7989450
    Abstract: Isoxazole derivatives, in particular diarylisoxazole derivatives inhibitors of cyclooxygenase (COX), in particular cyclooxygenase-1 (COX-1), their pharmaceutical compositions, the process for their preparation and their use for the chemoprevention and treatment of inflammatory syndromes and in the prevention and treatment of carcinomas, in particular intestinal, ovarian and cutaneous carcinomas, in the treatment of pain syndromes, in particular after surgery, and in the cardiovascular field as antithrombotics/vasoprotectives/cardioprotectives.
    Type: Grant
    Filed: January 11, 2008
    Date of Patent: August 2, 2011
    Assignees: Universita' Degli Studi Di Bari, Universita' Degli Studi “G.D.'Annunzio”—Chieti
    Inventors: Antonio Scilimati, Paola Vitale, Leonardo Di Nunno, Paola Patrignani, Stefania Tacconelli, Marta Luciana Capone
  • Process for preparing ligands of PPARdelta and the intermediate compounds for preparing the same
    Patent number: 7982050
    Abstract: The present invention provides a process for preparing thiazole derivatives of formula (I), that activate the delta subtype of the human Peroxisome Proliferator Activated Receptor (hPPAR ?), and also provides compounds of formula (II), (IV), (X), (XI) and (XII), intermediate compounds for preparation of the above compounds of formula (I).
    Type: Grant
    Filed: May 7, 2005
    Date of Patent: July 19, 2011
    Assignee: Seoul National University Industry Foundation
    Inventors: Heon Joong Kang, Jung Yeob Ham