Abstract: Personal care topical compositions at skin-tolerant pH with cystine which is solubilized or has small crystal size below 20 microns. A process of making the composition is also described.

Abstract: The present invention relates to a melt composite comprising one or more curcuminoids and a carrier selected from rice bran extract, mannitol, maltodextrin and mixtures thereof. The invention also provides a process for preparation of the melt composite, wherein the mixture of curcuminoids, rice bran extract, mannitol, maltodextrin and mixture thereof may be subjected to controlled conditions of heating and granulation. The melt composite may also be optionally comprised of one more excipient suitable for use for human consumption. Curcuminoid composites can be formulated in suitable solid, liquid or semisolid compositions. Curcuminoid composites and the compositions thereof, exhibit rapid dissolution and enhanced bioavailability.

Abstract: A rat attractant composition is disclosed which includes one or more isolated additives. The composition is attractive to at least rats of the species Rattus norvegicus. Devices including the rat attractant composition and methods of using a rat attractant composition are also disclosed.

Abstract: A peroxide delivery system is produced. The peroxide delivery system includes a dry powder that releases the peroxide quickly and completely when needed. The peroxide delivery system may be produced by combining a liquid peroxide or peroxide solution with an inorganic solid support that is inert to the peroxide and is capable of adsorbing large amounts of the liquid peroxide or peroxide solution while remaining dry to the touch. Methods of combining the inorganic solid support with the liquid peroxide or peroxide solution are disclosed. The peroxide delivery system can be formulated in preparations of powders, liquids, foams, sprays, gels, ointments, creams, sticks, or pastes that can be utilized in a variety of applications such as cleaning, stain removal and antiseptic products, for example.

Abstract: In exemplary embodiments, the disclosure provides a Colesevelam Colon Specific Drug Delivery System for use in treatment of, for example, cholestasis and/or cholestatic pruritus.

Abstract: The invention relates to a personal care product for alleviating skin dryness, includes facial skin dryness, breast skin dryness and vulval dryness and for restoring vaginal flora, acidic pH in the vagina, and vaginal health. Embodiments of the personal care product include a formulation including at least about 83 wt. % plant-based glycerides; from about 0.05 wt. % to about 0.15 wt. % sodium hyaluronate; and from about 0.01 wt. % to about 1.5 wt. % sea buckthorn powder. Another embodiment includes a personal care product including at least 55 wt. % plant-based glycerides and from about 20 wt. % to about 42 wt. % sucrose. The personal care product may also include shea olein. The person care product is substantially free of added water, alcohol, synthetic chemical, anti-microbial agent, and synthetic hormone.

Abstract: Antiperspirant and/or deodorant compositions and methods for the same are provided. The compositions may include an antiperspirant active or a deodorant active, water, and a preservative system. The antiperspirant active may include aluminum, and the preservative system may include a biodegradable amino carboxylate. The methods may include substituting or replacing a conventional chelant, such as EDTA, with a biodegradable chelant, such as HIDS. The methods may also include applying one of the compositions to an axillary area of a person.

Abstract: A composition comprising at least one dispersed fatty phase, and at least one continuous aqueous phase, and comprising: a) at least one hydrophobic gelling agent selected from ester of dextrin and fatty acid; b) at least one amphiphilic crosslinked copolymer; c) at least one anionic terpolymer, linear or branched, of at least one monomer (1) carrying an acid function in free form, partially or totally salified by a nonionic monomer (2) selected from N,N-dimethylacrylamide and 2-hydroxyethyl acrylate, and at least one monomer (3) polyoxethylenated alkyl acrylate of formula (III) wherein in formula (III): R1 represents a hydrogen atom, R represents a linear or branched C8-C16 alkyl radical, n is an integer ranging from 1 to 10; and d) at least one hydrophobic particles chosen from hydrophobic silicas, hydrophobic cellulose, starch, talc, silicone resin powders, hollow hemispherical silicone particles, polyamide powders, hydrophobic pigments, or a mixture thereof.

Abstract: This invention provides a more efficient means for treating inflammatory gastrointestinal diseases using CO. More specifically, the invention provides a composition for preventing and/or treating inflammatory gastrointestinal diseases, the composition comprising carbon monoxide and a solvent, the CO concentration being 800 ?M or more.

Abstract: A pharmaceutical formulation has (S)-[2-chloro-4-fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)phenyl]-(6-methoxy-pyridazin-3-yl)methanol or pharmaceutically acceptable salt thereof.

Abstract: The purpose of the present invention is to provide an injectable sol into a body, suited for delivery through a catheter, and usable for tissue perforation closure, ulcer protection, or vascular embolization. Provided are a sol for tissue perforation closure, a sol for ulcer protection, and a sol for vascular embolization, each containing from 0.6 mass % to 3 mass % of a collagen, water, from 200 mM to 330 mM sodium chloride, and a buffer and having a pH from 6.0 to 9.0.

Abstract: The present invention relates to, inter alia, pharmaceutical compositions comprising a polyunsaturated fatty acid and a statin and to methods of using the same to treat or prevent cardiovascular-related diseases.

Abstract: A pharmaceutical composition containing a mixed polymeric micelle and a drug enclosed in the micelle, in which the mixed polymeric micelle, 1 to 1000 nm in size, includes an amphiphilic block copolymer and a lipopolymer. Also disclosed are preparation of the pharmaceutical composition and use thereof for treating cancer.

Abstract: A low-viscosity water-in-oil cosmetic emulsion preparation gives a smooth use feeling, lightly spreads when applied, and has excellent dispersed-powder stability. The cosmetic emulsion preparation has (A) a polar oil which is liquid at 25° C. and has an IOB value exceeding 0.1, (B) a hydrocarbon oil, (C) a polyoxyalkylene; and alkyl-modified organopolysiloxane represented by general formula (I), and (D) a powder surface-treated with both an N-acylamino acid and methylpolysiloxane. (In formula (I), R represents a hydrogen atom or a C1-5 alkyl group, x is an integer of 5-50, y is an integer of 1-30, z is an integer of 20-200, a is an integer of 2-20, b is an integer of 1-5, c is an integer of 2-20, and d is an integer of 0-20).

Abstract: A room temperature injectable thermo-responsive hydrogel comprises a P407 poloxamer base hydrogel, chitosan, 2-Hydroxypropyl ?-cyclodextrin and genipin. The chitosan and genipin form an interpenetrating scaffold within the hydrogel in which the chitosan is crosslinked with genipin. Chemotherapeutic drugs can be added to the hydrogel singly or in combination in effective amounts without any loss of thermo-responsiveness in the hydrogel. Therapeutic use of the thermo-responsive hydrogel in the intratumoural treatment of solid cancer is also described.

Abstract: Emulsion comprising an anionic acrylic copolymer and a lipophilic polymer A subject of the present invention is a composition in the form of an emulsion, preferably in the form of an oil-in-water emulsion, comprising at least one hydrophilic gelling polymer chosen from anionic acrylic copolymers and at least one lipophilic polymer comprising at least hydroxyethyl acrylate units and acrylate units bearing a lipophilic group, wherein the weight ratio of the sum of all the hydroxyethyl acrylate units to the sum of all the acrylate units bearing a lipophilic group ranges from 1:30 to 1:1 and wherein the lipophilic polymer has a number-average molecular weight Mn ranging from 2000 to 9000 g/mol. The composition in accordance with the invention makes it possible to obtain emulsions which are homogeneous (the emulsion is macroscopically smooth and has no grains, after storage in a pot for 24 hours at ambient temperature (25° C.

Abstract: In exemplary embodiments, the disclosure provides a Colesevelam Colon Specific Drug Delivery System for use in treatment of, for example, cholestasis and/or cholestatic pruritus.

Abstract: A dry pharmaceutical composition is provided that is suitable for respiratory tract delivery of levodopa and DDI for treatment of Parkinson's disease or Parkinson syndrome. The dry pharmaceutical composition comprises levodopa, a dopa decarboxylase inhibitor (DDI) and at least one excipient. A unit dosage form of the dry pharmaceutical composition and a method of treating a patient with Parkinson's disease or Parkinson syndrome by administering the dry pharmaceutical composition are also provided.

Abstract: The present disclosure concerns a deodorant emulsion for an aerosol spray which is free from aluminum salts and ethanol, comprising: at least one emulsifier, at least one salt, water, at least one silicone oil and at least one further oil, and a deodorant aerosol spray product comprising a pressure or pump spray container with spray head, the filling of which comprises the deodorant emulsion and optionally a propellant and/or further solvent, and a use of the deodorant aerosol spray product for deodorizing human skin.

Abstract: The invention provides a liquid cosmetic that contains capsule in an aqueous medium, wherein the capsule comprises agar shell encapsulating an oil component, and the aqueous medium comprises a low molecular polyol and one selected from the group consisting of a (meth)acrylic polymer and a polysaccharide.