Patents Examined by Sreeni Padmanabhan
  • Propellant-free aerosol formulation for inhalation
    Patent number: 9238031
    Abstract: The present invention relates to propellant-free aerosol formulations for inhalation containing ipratropium bromide and salbutamol.
    Type: Grant
    Filed: November 22, 2013
    Date of Patent: January 19, 2016
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Christel Schmelzer, Franz-Rainer Weitzel
  • Compositions, synthesis, and methods of using phenylcycloalkylmethylamine derivatives
    Patent number: 9238625
    Abstract: The present invention provides novel phenylcycloalkylmethylamine derivatives, and methods of preparing phenylcycloalkylmethylamine derivatives. The present invention also provides methods of using phenylcycloalkylmethylamine derivatives and compositions of phenylcycloalkylmethylamine derivatives. The pharmaceutical compositions of the compounds of the present invention can be used for treating and/or preventing obesity and obesity related co-morbid indications and depression and depression related co-morbid indications.
    Type: Grant
    Filed: December 31, 2012
    Date of Patent: January 19, 2016
    Assignee: REVIVA PHARMACEUTICALS, INC.
    Inventors: Laxminarayan Bhat, Kouacou Adiey, Seema Rani Bhat
  • Viscoelastic surfactant as drift control agent in pesticide formulations
    Patent number: 9232787
    Abstract: Dual function viscoelastic surfactants (VES) which, when used in a pesticide formulation, are capable of producing a spray pattern between the patterns formed by spraying water and an aqueous pesticide solution containing guar gum as a way to reduce the drifting of the small drops to unintended targets while providing enhanced efficacy to the pesticide.
    Type: Grant
    Filed: December 7, 2011
    Date of Patent: January 12, 2016
    Assignee: AKZO NOBEL CHEMICALS INTERNATIONAL B.V.
    Inventors: Shawn Zhu, Michael Walters
  • Arginase inhibitors as therapeutics
    Patent number: 9233985
    Abstract: Compounds according to Formula I are potent inhibitors of Arginase I and II activity: where R1, R2, R3, R4, D, W, X, Y, and Z are defined in the specification. The invention also provides pharmaceutical compositions of the compounds and methods of their use in treating or preventing a disease or a condition associated with arginase activity.
    Type: Grant
    Filed: October 19, 2011
    Date of Patent: January 12, 2016
    Assignee: Mars, Incorporated
    Inventors: Michael Van Zandt, Gunnar Erik Jagdmann, Jr.
  • Sulfamides as TRPM8 modulators
    Patent number: 9233947
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein Y, R1, R2, R3, R4, RA, and RB are defined herein.
    Type: Grant
    Filed: May 7, 2014
    Date of Patent: January 12, 2016
    Assignee: Janssen Pharmaceutica, NV
    Inventor: Jay M Matthews
  • Aqueous composition comprising bromhexine
    Patent number: 9220693
    Abstract: The present invention relates to aqueous compositions containing bromhexine, the composition comprising an amount of sugar alcohols of less than 10 g based on 100 ml of the composition, and the use thereof for secretolytic therapy in acute and chronic bronchopulmonary disorders.
    Type: Grant
    Filed: July 7, 2011
    Date of Patent: December 29, 2015
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Uwe Scheuring, Bernd Plohmann, Annette Zamponi
  • Fused cyclooctyne compounds and their use in metal-free click reactions
    Patent number: 9222940
    Abstract: The invention relates to fused cyclooctyne compounds, and to a method for their preparation. The invention also relates to a conjugate wherein a fused cyclooctyne compound according to the invention is conjugated to a label, and to the use of these conjugates in bioorthogonal labeling, imaging and/or modification, such as for example surface modification, of a target molecule. The invention further relates to a method for the modification of a target molecule, wherein a conjugate according to the invention is reacted with a compound comprising a 1,3-dipole or a 1,3-(hetero)diene.
    Type: Grant
    Filed: October 10, 2014
    Date of Patent: December 29, 2015
    Assignee: SynAffix B.V.
    Inventors: Floris Louis Van Delft, Floris Petrus Johannes Theodorus Rutjes, Frederik Jan Dommerholt
  • Solid dispersions of amorphous paroxetine mesylate
    Patent number: 9211290
    Abstract: The invention relates to solid dispersions containing paroxetine mesylate. One solid dispersion contains amorphous paroxetine mesylate and a methacrylic acid-methyl methacrylate copolymer, where the weight ratio of paroxetine mesylate to polymer ranges from about 30:70 to about 90:10. Another solid dispersion contains amorphous paroxetine mesylate and a -vinylpyrrolidone/vinylacetate copolymer (PVP-VA), where the weight ratio of paroxetine mesylate to copolymer ranges from about 30:70 to about 50:50. An amorphous solid dispersion of the invention may have a single glass transition temperature. An amorphous solid dispersion is stable for at least 48 hours at 60° C. and 75% relative humidity. A further embodiment of the invention relates to pharmaceutical compositions of paroxetine mesylate comprising a solid dispersion of the invention and at least one pharmaceutically acceptable excipient.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: December 15, 2015
    Assignee: NOVEN THERAPEUTICS, LLC
    Inventors: David A. Engers, Yonglai Yang, Stephan Parent, Travis Houston, Bruce Charles Friedman
  • Methods and devices for using isoperillyl alcohol
    Patent number: 9211269
    Abstract: The present invention provides for a method of treating a disease such as cancer, comprising the step of administering to a patient a therapeutically effective amount of an isomer or analog of monoterpene or sesquiterpene (or its derivative), such as an isoperillyl alcohol. The present invention also provides for a method of treating a disease comprising the step of administering to a patient a therapeutically effective amount of a derivative of an isomer or analog of monoterpene or sesquiterpene, such as an isoperillyl alcohol carbamate. The derivative may be an isoperillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The route of administration may vary, including inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.
    Type: Grant
    Filed: December 16, 2011
    Date of Patent: December 15, 2015
    Assignee: NEONC TECHNOLOGIES INC.
    Inventors: Thomas Chen, Daniel Levin, Satish Pupalli, Daniel A Dickman
  • Inhibitors of viral entry into mammalian cells
    Patent number: 9212134
    Abstract: The present invention is related to the development of compounds and methods for inhibiting viral infection in a mammal. A pseudotype virus was developed for use in a high throughput assay for identifying nonpeptidic small molecule inhibitors that prevent viral entry into a host cell.
    Type: Grant
    Filed: September 13, 2011
    Date of Patent: December 15, 2015
    Assignee: Microbiotix, Inc.
    Inventors: Arnab Basu, Debra M. Mills, John D. Williams, Bing Li, Norton P. Peet, Terry L. Bowlin
  • Hypophosphorous acid derivatives having antihyperalgic activity and biological applications thereof
    Patent number: 9212196
    Abstract: The invention relates to hypophosphorous acid derivatives of formula (I) wherein —X is H or OH, —R represents one or several radicals R1-R5, identical or different, two of R1-R5 optionally occupying the same position on the phenyl group, one to four of R1-R5 being H and the others being selected in the group comprising -0-(CH2)n—COOH; —S—(CH2)n—COOH; —NH—(CH2)n—COOH; -0-(CH,R?)—COOH; —O—(CH2)n—OH; OR?, —R? being a C1-C3 alkyl radical; —OH; —COOH; halogen, particularly —F, —CI, —Br, —I, —CF3; —OCF3; —N02; —CH?CH—COOH; —(CH2)n—COOH; O—(CH2)n—P03H2; O—(CF2)n—P03H2; O—(CH2)n—S03H; O—(CH2)n—CONHOH; O—(CH2)n-tetrazol; O—(CH2)n-hydroxyisoxazol—n=1 to 5, preferably 1-3; said hypophosrous acid derivatives being diastereoisomers or enantiomers.
    Type: Grant
    Filed: May 16, 2012
    Date of Patent: December 15, 2015
    Assignees: UNIVERSITE PARIS DESCARTES, UNIVERSITE D'AUVERGNE
    Inventors: Francine Acher, Jean-Philippe Pin, Cyril Goudet, Alain Eschalier, Jérôme Busserolles, Delphine Rigault, Isabelle Lemasson, Sara Cesarini, Bruno Commare
  • Use of 2-methylene-19-nor-(20S)-1?,25-dihydroxyvitamin Dto treat secondary hyperparathyroidism
    Patent number: 9205096
    Abstract: Disclosed are methods of administering 2-methylene-19-nor-(20S)-1?,25-dihydroxyvitamin D3 to treat and/or prevent secondary hyperparathyroidism and/or its accompanying symptoms in a subject having or at risk for developing secondary hyperparathyroidism.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: December 8, 2015
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Lori A. Plum, Julia B. Zella, Margaret Clagett-Dame
  • Compositions and methods for the treatment of neurological diseases
    Patent number: 9206111
    Abstract: The compositions and compounds of formula I, formula II, formula III and formula IV which includes a salt of valproic acid or its polymorphs, enantiomers, stereoisomers, solvates, and hydrates thereof. These salts may be formulated as pharmaceutical compositions. The pharmaceutical compositions comprising an effective amount of compounds of formula I, formula II, formula III and formula IV and methods for treating or preventing neurological diseases may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of epilepsy, bipolar disorder, migraine, schizophrenia, depression, Alzheimer's disease, cancer, HIV and familial adenomatous polyposis.
    Type: Grant
    Filed: December 17, 2014
    Date of Patent: December 8, 2015
    Assignee: CELLIX BIO PRIVATE LIMITED
    Inventor: Mahesh Kandula
  • Animal repellent
    Patent number: 9198427
    Abstract: The present invention provides an animal repellent comprising, as an active ingredient, a compound having an odor innately inducing fear in animals, which is free from acclimation of animals to the aforementioned odor. The present invention relates to animal repellent comprising, as an active ingredient, at least one kind selected from a heterocyclic compound represented by the formula (1): wherein ring A is a 3- to 7-membered heterocycle containing at least one hetero atom selected from a nitrogen atom, a sulfur atom and an oxygen atom, and R1 and R2 are each independently hydrogen, a halogen atom, an optionally substituted alkyl group, an optionally substituted alkoxy group, an acyl group, an optionally esterified carboxyl group, an optionally substituted thiol group, an optionally substituted amino group or an oxo group, or a salt thereof, a chain sulfide compound and alkyl isothiocyanate.
    Type: Grant
    Filed: February 8, 2011
    Date of Patent: December 1, 2015
    Assignee: Scent Science International Inc.
    Inventors: Ko Kobayakawa, Reiko Kobayakawa
  • Aminoindanes amides having a high fungicidal activity and their phytosanitary compositions
    Patent number: 9192160
    Abstract: New aminoindanes amides are described, having general formula (I) the relative phytosanitary compositions and their use for the control of phytopathogenic fungi.
    Type: Grant
    Filed: December 19, 2011
    Date of Patent: November 24, 2015
    Assignee: STICHTING I-F PRODUCT COLLABORATION
    Inventors: Isabella Venturini, Matteo Santino Vazzola, Entela Sinani, Franco Pellacini, Lucio Filippini
  • Use of quinazoline derivatives for neurodegenerative diseases
    Patent number: 9192610
    Abstract: The present invention relates to the use of a series of quinazoline-derived compounds to produce a medicament for the treatment and/or prevention of neurological and/or neurodegenerative diseases, such as Parkinson's disease or Alzheimer's disease. The present invention also relates to a method for the treatment and/prevention of neurological and/neurodegenerative diseases comprising the administration of a therapeutically effective amount of said compounds.
    Type: Grant
    Filed: May 20, 2010
    Date of Patent: November 24, 2015
    Assignee: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
    Inventors: Ana Martínez Gil, Carmen Gil Ayuso-Gontan, Concepción Pérez Martín, Ana Pérez Castillo, José Morales García, Miriam Redondo Sancho, Marina Sanz San Cristóbal
  • Use of polyhexamethylene guanidine hydrochloride as preservative to control citrus sour rot and its application
    Patent number: 9192162
    Abstract: The use of polyhexamethylene guanidine hydrochloride as preservative for preventing and controlling citrus sour rot and its application are disclosed by the present invention. The citrus preservative calculated by 100% total mass fraction comprises 0.05%-0.5% polyhexamethylene guanidine hydrochloride, 0.05%-0.2% of one or more selected from the group consisting of a mixture of several of the following: 0.05%-0.2% imidazole fungicidebactericide, benzimidazole fungicidebactericide, pyrimethanil, fludioxonil and azoxystrobin, and 0.02%-0.15% polyethenoxy ether emulsion or quaternary ammonium salt emulsion, and the rest is water. The citrus preservative can significantly inhibit the decay of citrus fruit such as Citrus microcarpa during storage, especially the incidence of sour rot. So the commercial value of citrus is obviously increased.
    Type: Grant
    Filed: November 15, 2010
    Date of Patent: November 24, 2015
    Assignee: SOUTH CHINA BOTANICAL GARDEN, CHINESE ACADEMY OF SCIENCES
    Inventors: Xuewu Duan, Yueming Jiang, Linyan Feng, Fuwang Wu
  • Compositions and methods for treating parkinson's disease
    Patent number: 9192605
    Abstract: This application describes compositions of receptor inhibitors, including typical antipsychotic agents, for example haloperidol, and methods of use for treating clinical signs or symptoms of Parkinson's disease. Furthermore, this application describes compositions and methods to induce supersensitivity in dopamine D2 and other receptors involved in Parkinson's disease as a means of alleviating the clinical signs or symptoms of Parkinson's disease.
    Type: Grant
    Filed: July 30, 2010
    Date of Patent: November 24, 2015
    Assignee: CLERA INC.
    Inventor: Philip Seeman
  • Oxazole derivatives useful as modulators of FAAH
    Patent number: 9193697
    Abstract: The present invention is directed to certain Oxazole derivatives which are useful as modulators of Fatty Acid Amide Hydrolase (FAAH) and as FAAH imaging agents. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including osteoarthritis, rheumatoid arthritis, diabetic neuropathy, postherpetic neuralgia, skeletomuscular pain, and fibromyalgia, as well as acute pain, migraine, sleep disorder, Alzheimer Disease, and Parkinson's Disease.
    Type: Grant
    Filed: April 4, 2011
    Date of Patent: November 24, 2015
    Assignee: MERCK SHARP & DOHME CORP.
    Inventors: ZhiQiang Yang, Philippe G. Nantermet, Constantine Kreatsoulas, Keith P. Moore, Evan Foster Shalen
  • Salt(s) of 7-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-D]pyrimidine-6-carboxylic acid dimethylamide and processes of making thereof
    Patent number: 9193732
    Abstract: This invention relates to (1) process of making 7-Cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide and salts thereof; (2) novel salt(s) of 7-Cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide; (3) pharmaceutical compositions comprising the same; and (4) methods of treatment using the same.
    Type: Grant
    Filed: November 9, 2011
    Date of Patent: November 24, 2015
    Assignees: Novartis AG, Astex Therapeutics, LTD
    Inventors: John Vincent Calienni, Guang-Pei Chen, Baoqing Gong, Prasad Koteswara Kapa, Vishal Saxena