Patents Examined by Steven Pohnert
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Patent number: 8846312Abstract: The present invention provides rapid and accurate methods, primers, probes and kits for identifying the presence of a certain flaviviruses in a sample. Flaviviruses that can be detected include members of the Japanese encephalitis virus serogroup, Dengue virus, St. Louis encephalitis virus, Montana myotis leukoencephalitis virus, Modoc virus, and Yellow Fever virus. The primers and probes of the invention can hybridize to regions in the 3? untranslated region of the viral genomes to be detected.Type: GrantFiled: April 16, 2013Date of Patent: September 30, 2014Assignee: Roche Molecular Systems, Inc.Inventor: Karen K. Y. Young
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Patent number: 8841429Abstract: The invention generally relates to nucleic acid ligands that specifically bind to infectious prions, and methods of diagnosing a transmissible spongiform encephalopathy disease in a subject. In certain embodiments, the invention provides an isolated nucleic acid ligand that binds to an infectious prion. In other embodiments, the invention provides a method for diagnosing a transmissible spongiform encephalopathy disease in a subject including obtaining a tissue or body fluid sample from a subject, contacting the tissue or body fluid with a nucleic acid ligand that binds to an infectious prion, thereby detecting the infectious prion in the sample, and diagnosing the transmissible spongiform encephalopathy disease based on results of the contacting step.Type: GrantFiled: November 3, 2009Date of Patent: September 23, 2014Assignee: Vivonics, Inc.Inventor: Vladimir Leo Gilman
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Patent number: 8795972Abstract: Provided herein are methods, kits and compositions to classify fungi. Methods are provided for classification of fungi according to established phenotypes, for example, antimicrobial susceptibility profiles. More specifically, the invention provides methods for the use of PNA probes in diagnostic applications, which will aid in the direction of appropriate therapy against fungi.Type: GrantFiled: October 15, 2008Date of Patent: August 5, 2014Assignee: AdvanDx, Inc.Inventors: Mark Fiandaca, Henrik Stender
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Patent number: 8685642Abstract: Methods and systems for allelic detection and allele-specific copy number are provided herein. The described methods use identification of single nucleotide polymorphism using restriction enzymes and CGH analysis. Microarrays comprising probes designed by the described methods are provided. Also included are methods for identifying SNP sites and copy number in samples obtained from patient populations.Type: GrantFiled: July 30, 2007Date of Patent: April 1, 2014Assignee: Agilent Technologies, Inc.Inventor: Nicholas Michael Sampas
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Patent number: 8637235Abstract: The present invention concerns the V617F variant of the protein-tyrosine kinase JAK2, said variant being responsible for Vaquez Polyglobulia. The invention also relates to a first intention diagnostic method for erythrocytosis and thrombocytosis allowing their association with myeloproliferative disorders, or to the detection of the JAK2 V617F variant in myeloproliferative disorders allowing their reclassification in a new nosological group.Type: GrantFiled: September 19, 2008Date of Patent: January 28, 2014Assignees: Institut Gustave-Roussy, Institut National de la Sante et de la Recherche Scientifique (CNRS), Assistance Publique—Hopitaux de Paris, Universite de Versailles—St Quentin en Yvelines, Universite Paris—SUDInventors: William Vainchenker, Valérie Ugo, Chloé James, Jean-Pierre Le Couedic, Nicole Casadevall
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Patent number: 8299233Abstract: The invention relates to the use of a multiplicity of polynucleotide probe sets, the multiplicity of polynucleotide probe sets consisting in a combination of pools of polynucleotide probe sets, each polynucleotide probe set containing at least one polynucleotide probe chosen among a library of nucleic acid sequences, the polynucleotide probes involved in the combination of pools of polynucleotide probe sets of the multiplicity of polynucleotide probe sets being such that each polynucleotide probe specifically hybridizes with one gene, and/or at least one of its variants when present, for determining the variation of expression at least 12 genes, and their variants when present, in order to diagnose the benign or malignant state of a breast tumor.Type: GrantFiled: January 5, 2009Date of Patent: October 30, 2012Assignees: Centre National de la Recherche Scientifique, Institut Gustave RoussyInventors: Fabrice Andre, Stefan Michiels, Suzette Delaloge, Marc Spielmann, Philippe Dessen, Philippe Vielh
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Patent number: 8268562Abstract: The present invention relates to novel genetic markers associated with response of a patient with esophageal cancer (ECa) to chemoradiation therapy, and particularly to methods and kits for predicting an ECa patient's response to chemoradiation therapy by genotyping of the markers.Type: GrantFiled: October 20, 2009Date of Patent: September 18, 2012Assignee: National Taiwan UniversityInventors: Pei-Chun Chen, Yen-Ching Chen, Liang-Chuan Lai, Mong-Hsun Tsai, Shin-Kuang Chen, Pei-Wen Yang, Jang-Ming Lee, Eric Y. Chuang, Chuhsing K. Hsiao
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Patent number: 8247175Abstract: Methods and compositions for determining the suitability of a lung for transplantation are described.Type: GrantFiled: February 2, 2007Date of Patent: August 21, 2012Assignee: University Health NetworkInventors: Shaf Keshavjee, Thomas K. Waddell, Mingyao Liu
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Patent number: 8129112Abstract: Provided are polynucleotides of molecular variant promoters of the CYP2D6 gene which, for example, are associated with abnormal drug response or individual predisposition to several common diseases and disorders caused by drug under- or over-metabolization, and vectors comprising such polynucleotides. Furthermore, methods of diagnosing the status of disorders related to intermediate metabolization of drugs are described. In addition, kits comprising oligonucleotides hybridizing to the CYP2D6 promoter and/or being capable of being extended into this region useful for diagnosing subjects that are ultrarapid or intermediate metabolizer of drugs are provided.Type: GrantFiled: January 30, 2001Date of Patent: March 6, 2012Assignee: PGxHealth, LLCInventors: Sebastian Raimundo, Ulrich Zanger
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Patent number: 8129117Abstract: This document provides methods and materials related to genetic markers of Bipolar Disorder (BD) and Schizophrenia (SZ). For example, methods for using such genetic markers to assess risk of developing BD and/or SZ are provided, as are methods for making a differential diagnosis between BD and SZ.Type: GrantFiled: November 4, 2009Date of Patent: March 6, 2012Assignee: SureGene LLCInventors: Mark David Brennan, Timothy Lynn Ramsey
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Patent number: 8092996Abstract: The present invention relates to methods for amplifying various regions of the cystic fibrosis transmembrane regulator (CFTR) gene. Methods are provided for amplifying one or all 27 exons of the CFTR gene and a portion of the CFTR promoter region in a single tube. The method can identify the presence or absence of CF deletions or insertions in a sample and assist in the diagnosis of a genetic predisposition to cystic fibrosis.Type: GrantFiled: September 16, 2004Date of Patent: January 10, 2012Assignee: Quest Diagnostics Investments IncorporatedInventor: Feras Hantash
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Patent number: 8080373Abstract: A method for the early diagnosis of pancreatic cancer and other gastrointestinal disease compares the gene expression patterns from a patient's peripheral blood monocytes-lymphocyte's gene system with either the similar gene expression patterns of a normal person, or with the similar gene expression patterns of a person known to have the condition being screened for. Differences between the patient's gene expression patterns for particular genes and the normal patterns indicates the presence of the condition with the number of differences indicating the probability of the condition. Similarities between the patient's gene expression patterns for those particular genes and the patterns of a person known to have the condition indicates the presence of the condition with the number of similarities indicating the probability of the condition. Particular genes for use in identifying pancreatic cancer are disclosed.Type: GrantFiled: August 1, 2005Date of Patent: December 20, 2011Inventor: A. Robert Bauer, Jr.
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Patent number: 8076074Abstract: The present invention provides comparative genomic hybridization methods for detecting and mapping chromosomal or genetic abnormalities associated with various diseases or with predisposition to various diseases, or to detecting the phenomena of large scale copy number variants. The method includes hybridization with one or more probes for detecting balanced translocations. Such probes may be complementary to the moving genomic segment which is translocated or may be complementary to the translocation break point.Type: GrantFiled: November 29, 2005Date of Patent: December 13, 2011Assignee: Quest Diagnostics Investments IncorporatedInventor: Mansoor S. Mohammed
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Patent number: 8062842Abstract: Methods and kits are provided for determining whether a subject is at risk of developing a neurological disease such as Alzheimer's disease and multiple sclerosis. The methods and kits are based on the detection of one or more nucleic acid variants in the MBL gene of the subject.Type: GrantFiled: June 10, 2008Date of Patent: November 22, 2011Assignee: Abbott Healthcare Products B.V.Inventors: Eugeen Vanmechelen, Lieve Nuytinck
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Patent number: 8058055Abstract: The present invention generally relates to spatial and structural genomic analysis compositions, which can be used for the mapping of chromosomes and structural analyses of chromosomal rearrangements, including the entire chromosome, as well as specific portions or regions of interest of the chromosomes. In some embodiments, multiple portions of the genome can be distinguished, for instance, using a first detection entity and a second detection entity different from the first detection entity. The detection entities may be immobilized relative to oligonucleotides, which may be selected to bind to different locations within the chromosome. For instance, the oligonucleotides may be at least substantially complementary to the chromosome, e.g., substantially complementary to a specific location of the chromosome.Type: GrantFiled: April 7, 2006Date of Patent: November 15, 2011Assignee: Agilent Technologies, Inc.Inventors: Michael Thomas Barrett, Michael P. Caren
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Patent number: 8003328Abstract: Methods of predicting the phenotype of a trait in a bovine subject are provided. The methods include obtaining information about polynucleotide sequences specifically regarding the identity of the nucleotides present at one or more identified single nucleotide polymorphisms and using this information to make predictions regarding the trait in the subject. Also provided are kits for and methods of determining the nucleotide present in a bovine subject at a position in which a single nucleotide polymorphism is correlated with a trait.Type: GrantFiled: February 2, 2009Date of Patent: August 23, 2011Assignee: The Board of Trustees of the University of ArkansasInventor: Charles F. Rosenkrans, Jr.
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Patent number: 7993853Abstract: Methods for efficiently capturing a target nucleic acid from a sample by using a mixture that contains a capture probe specific for the target nucleic acid, the target nucleic acid, and a denaturant chemical, which mixture is incubated at elevated temperature for a short time, are disclosed. Compositions that include a capture probe that specifically binds to a target nucleic acid and a denaturant chemical, which when mixed with the target nucleic acid and incubated at elevated temperature for a short time, promote efficient hybridization of the capture probe and target nucleic acid are disclosed.Type: GrantFiled: May 5, 2006Date of Patent: August 9, 2011Assignee: Gen-Probe IncorporatedInventors: Reinhold B. Pollner, Michael M. Becker, Mehrdad R. Majlessi
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Patent number: 7972790Abstract: The present invention provides for selection of livestock animals, including bovines, whose genotypes based in the STAT6 gene are correlated with phenotypes reflecting desirable carcass and feedlot traits. These phenotypes include back fat (BFAT), calculated yield grade (CALCYG), cutability (CUT), hot carcass weight (HCW), dry matter intake (DMI), days on feed (DOF), back fat rate (BFAT RATE) and average daily gain (ADG), based on the knowledge of the STAT6 genotypes. The predictive value is based in part on the discovery that certain single nucleotide polymorphisms (SNPs) within the STAT6 gene are linked to phenotypes of economically these important carcass and feedlot traits. Also provided are SNPs within the STAT6 gene useful in reliably distinguishing between a Bos taurus and a Bos indicus bovine.Type: GrantFiled: April 30, 2008Date of Patent: July 5, 2011Assignees: The Regents of the University of California, MerialInventors: Juan F. Medrano, Gonzalo Rincon, Charles Farber, Donald Joshua Nkrumah