Abstract: The present the invention provides methods, devices and systems for rapidly measuring analytes within a biological sample.

Abstract: A multiple-electrode ion meter (100) is provided. The multiple-electrode ion meter (100) includes meter electronics (102) configured to receive a plurality of ionic concentration voltage measurements and generate an ionic concentration measurement from the plurality of ionic concentration voltage measurements and three or more individual electrode units (108) in communication with the meter electronics (102). The three or more electrode units (108) generate the plurality of ionic concentration voltage measurements to the meter electronics (102).

Abstract: A system for collecting target nucleic acids from a sample can include at least one sample chamber configured to receive a sample containing target nucleic acids and other material, at least one collection chamber removably mountable relative to the at least one sample chamber and configured to collect target nucleic acids separated from the other material, a filter removably mountable relative to the at least one sample chamber and configured to be disposed between the at least one sample chamber and the at least one collection chamber when the at least one collection chamber is mounted relative to the at least one sample chamber.

Abstract: A pushpen electrode is provided for electrophysiology measurements. The pushpen operation is used to impale a cell membrane in cell-attached configuration to go whole-cell without disruption of the gigaseal. The pushpen electrode has advantages over the conventional patch clamp electrode in reducing tip series resistance, increasing signal bandwidth, permitting longer-term recordings and reducing diffusion between the cytosol and the electrode solution.

Abstract: Described and illustrated herein are systems and exemplary methods of operating a multianalyte measurement system having a meter and a test strip. In one embodiment, the method may be achieved by applying a test voltage between a reference electrode and a first working electrode; measuring a first test current, a second test current and a third test current at the working electrode with the meter after a blood sample containing an analyte is applied to the test strip; estimating a hematocrit-corrected analyte concentration from the first, second and third test currents; and displaying the hematocrit-corrected analyte concentration.

Abstract: Methods and devices for sequencing nucleic acids are disclosed herein. Devices are also provided herein for measuring DNA with nano-pores sized to allow DNA to pass through the nano-pore. The capacitance can be measured for the DNA molecule passing through the nano-pore. The capacitance measurements can be correlated to determine the sequence of base pairs passing through the nano-pore to sequence the DNA.

Abstract: Micromachined reference electrodes for use in miniaturized electrochemical sensors, and methods for fabricating such reference electrodes and electrochemical sensors, for example, as a part of a microfluidic system, are disclosed. Electrochemical measurements allow for inexpensive detection of a wide variety of (bio-)chemical compounds in solution. The reference electrode is one of the main parts of an electrochemical cell. The reference electrode, from which no current is drawn, has a stable, constant potential.

Abstract: An amperometric probe suitable for monitoring chlorine levels in water is described. The probe has low power consumption and maintenance requirements rendering it particularly suitable for long periods of operation in remote locations with portable power supplies.

Abstract: A nanoparticle translocation device includes a first reservoir having a first reservoir electrode, a second reservoir having a second reservoir electrode, and at least one nanopore providing fluid communication between the first and second reservoirs. The device also includes one or more inner electrode portions on an inner wall of the nanopore and one or more outer electrode portions disposed on an outer wall of the nanopore. The device further includes at least one DC voltage supply for selectively applying a DC voltage to each of the first reservoir electrode, the second reservoir electrode, and the outer electrode layer, where the inner electrode portions, the outer electrode portions, and the nanopore are in a substantially coaxial arrangement.

Abstract: Described herein is an electrochemical enzymatic analyte test strip and method for making the test strip. The test strip utilizes isolated conductive areas inside the electrodes to define electrode whiskers. The method utilizes laser ablation to define electrode patterns.

Abstract: A method for distinguishing between types of electrochemical test sensors in a meter is disclosed. The method comprises the acts of providing an electrochemical test sensor comprising an enzyme and a chemical additive, contacting the test sensor to the meter to form an electrical connection, applying a potential having a magnitude sufficient to initiate a redox reaction of the chemical additive, and determining which type of electrochemical test sensor is being used based on whether a predetermined signal has been generated after the potential has been applied. The meter is adapted to determine an analyte concentration in a fluid sample.

Abstract: A gas sensor includes a gas sensor element. The gas sensor element includes a first detection chamber; a first oxygen pumping cell including a first solid electrolyte body and a pair of first electrodes; a second detection chamber; a second oxygen pumping cell including a second solid electrolyte body and a pair of second electrodes; and an oxygen-concentration sensing cell including a third solid electrolyte body and a pair of third electrodes. A sensing electrode of the third electrodes is disposed downstream beyond a first inner electrode of the first electrodes relative to a gas flow direction. A cross-sectional area of a space of the first detection chamber which faces the first inner electrode falls within a range from 0.03 mm2 to 0.22 mm2.

Abstract: An ion sensor includes: a conductive base structure including a substrate and an electrode film formed on the substrate; a plurality of ion-sensitive nanorods protruding from the electrode film; and an encapsulant enclosing the conductive base structure, surrounding the ion-sensitive nanorods, and formed with a window for exposing the ion-sensitive nanorods. Each of the ion-sensitive nanorods has a conductive core and an ion-sensitive layer formed on and enclosing the conductive core. The ion-sensitive material exhibits an ion selectivity of absorbing an ion of interest thereon for inducing a surface potential corresponding to concentration of the ion of interest.

Abstract: The present invention provides methods and apparatuses for analyte detection.

Abstract: A unitary ionic probe is provided. The unitary ionic probe includes a substantially elongate body including a central axis (AA), a proximal end, and a distal end. The unitary ionic probe further includes an active ion sensitive region that is located on and bonded into an exterior of the elongate body in a region of the proximal end and an active electrode in ionic communication with the active ion sensitive region. The unitary ionic probe further includes a reference ion sensitive region that is located on and bonded into the exterior of the elongate body and is spaced-apart from the active ion sensitive region and a reference electrode in ionic communication with the reference ion sensitive region.

Abstract: An electrode “cell” for use in a capacitive deionization (CDI) reactor consists of the electrode support structure, a non-reactive conductive material, the electrode accompaniment or substrate and a flow through screen/separator. These “layers” are repeated and the electrodes are sealed together with gaskets between two end plates to create stacked sets of alternating anode and cathode electrodes in the CDI reactor.

Abstract: A new microfluidic system comprising an automated prototype insulator-based dielectrophoresis (iDEP) triggering microfluidic device for pathogen monitoring that can eventually be run outside the laboratory in a real world environment has been used to demonstrate the feasibility of automated trapping and detection of particles. The system broadly comprised an aerosol collector for collecting air-borne particles, an iDEP chip within which to temporarily trap the collected particles and a laser and fluorescence detector with which to induce a fluorescence signal and detect a change in that signal as particles are trapped within the iDEP chip.

Abstract: Using multiple dichroics mirrors to split and redirect different wavelength regions of light in a multi-wavelength fluorescence detection system.

Abstract: The chip includes electrodes on a substrate. The electrodes include a working electrode, a reference electrode, and a counter electrode. The reference electrode is constructed so as to not have an intrinsic potential. A self-assembly monolayer is positioned on the reference electrode. The self-assembly monolayer includes spacers and active probes. The active probes are configured to have a higher affinity for a capture probe than the spacers have for the capture probe.

Abstract: Electrochemical transducer arrays are already known from the prior art. According to the invention, the transducer array is provided with at least one flexible, planar metal substrate on which at least one flexible insulator having a firm connection between the metal surface and the insulator surface is disposed. The metal substrate and the insulator disposed thereon are structured in such a manner as to give metal areas which are electrically insulated the one from the other and which serve as sensor areas. The metal substrate used is self-contained so that the structured metal areas can be contacted from the lower side.