Abstract: There is provided a beraprost sodium-containing nanoparticle that contains beraprost sodium among other prostaglandin I2 (prostacyclin) derivatives, which are therapeutic agents for pulmonary hypertension. The beraprost sodium-containing nanoparticle is obtained by making beraprost sodium hydrophobic using a metal ion and allowing the hydrophobic beraprost sodium to react with poly-L-lactic acid or a poly(L-lactic acid/glycolic acid) copolymer, and a poly-DL- or L-lactic acid-polyethylene glycol block copolymer or a poly(DL- or L-lactic acid/glycolic acid)-polyethylene glycol block copolymer. The beraprost sodium-containing nanoparticle excels in sustained release of an active ingredient, reduces a side effect, and furthermore, has an excellent drug retention in the blood. Therefore, the beraprost sodium-containing nanoparticle is quite outstanding particularly regarding the sustainability of the medicinal effect.
Type:
Grant
Filed:
February 13, 2012
Date of Patent:
October 20, 2015
Assignee:
LTT BIO-PHARMA CO., LTD.
Inventors:
Toru Mizushima, Tsutomu Ishihara, Hongxing Liu
Abstract: The present invention provides methods and compositions for improving plant health. In particular, application of dicamba or another substrate of DMO, or metabolites thereof including DCSA, to a plant confers tolerance to, or defense against, abiotic or biotic stresses such as oxidative stress including herbicide application, and plant disease, and enhances crop yield. Such application may be in combination with the application of another herbicide such as glyphosate.
Abstract: Methods are provided for the production of granular composite compositions including at least two pesticidally active ingredients in combination such as insecticidally active and herbicidally active ingredients and to the composite combination products produced thereby.
Type:
Grant
Filed:
October 24, 2007
Date of Patent:
October 13, 2015
Assignee:
OMS Investments, Inc.
Inventors:
Robert M. A. Radabaugh, Jonathan C. Raistlin Newton
Abstract: The patent provides a process of preparing a pharmaceutical preparation of glatiramer acetate and mannitol in a suitable container comprising the steps of: (i) obtaining an aqueous pharmaceutical solution of glatiramer acetate and mannitol; (ii) filtering the aqueous pharmaceutical solution at a temperature of from above 0° C. up to 17.5° C. to produce a filtrate; and (iii) filling the suitable container with the filtrate obtained after performing step (ii), so as to thereby prepare the pharmaceutical preparation of glatiramer acetate and mannitol in the suitable container. This patent further provides an aqueous pharmaceutical solution comprising 40 mg/ml glatiramer acetate and 40 mg/ml mannitol, wherein the aqueous pharmaceutical solution a) has a viscosity in the range of 2.0-3.5 cPa; or b) has an osmolality in the range of 275-325 mosmol/Kg. This patent also provides a prefilled syringe, an automated injector and a method of treatment of a human patient.
Type:
Grant
Filed:
January 28, 2015
Date of Patent:
October 13, 2015
Assignee:
TEVA PHARMACEUTICAL INDUSTRIES, LTD.
Inventors:
Rakefet Cohen, Sasson Habbah, Muhammad Safadi
Abstract: The present invention relates to a dry composition for reconstitution in water comprising polyethylene glycol (PEG), optionally sodium sulphate, citric acid, sodium citrate, sodium chloride, potassium chloride, simethicone, effective for bowel cleansing, in particular of colon, prior to diagnostic, surgical or therapeutical procedures, in particular colonoscopy.
Abstract: The present invention relates to the use of dithiine-dicarboximide compounds of formula I as defined in the description, and the N-oxides, and salts thereof for combating harmful fungi and seed coated with at least one such compound. The invention also relates to novel dithiine-dicarboximides, processes and intermediates for preparing these compounds and also to compositions comprising at least one such compound.
Type:
Grant
Filed:
April 10, 2012
Date of Patent:
September 22, 2015
Assignee:
BASF SE
Inventors:
Wassilios Grammenos, Nadege Boudet, Richard Riggs, Jochen Dietz, Egon Haden, Marcus Fehr
Abstract: The present invention comprises formulations for agricultural use comprising a surfactant and pesticide. The surfactants comprise nitrogen containing surfactants with N+—CH2COO?, N+—CH2COOCH3, N—CH2COO?M+, N—CH2CH2COO?M+, and/or amine oxide functionalities which enhance the pesticide activity. The pesticides include herbicides, fungicides and insecticides.
Type:
Grant
Filed:
August 30, 2010
Date of Patent:
September 22, 2015
Assignee:
AKZO NOBEL CHEMICALS INTERNATIONAL B.V.
Inventors:
Shawn Zhu, Joshua Jurs, Elliot Isaac Band, Michael Walters
Abstract: The invention provides a composition containing extracts from salvia miltiorrhiza bunge, gynostemma pentaphyllum mak, Chinese magnoliavine, cordyceps extract piece, pollen pini, and semen persicae and methods of and using the same.
Type:
Grant
Filed:
May 15, 2006
Date of Patent:
September 22, 2015
Assignees:
Shanghai Sundise Chinese Medicine Technology Development Co., Ltd., Shanghai Huanghai Pharmaceutical Co., Ltd.
Inventors:
Ning Zhang, Cheng Rong Wang, Ping Liu, Hua Shi Bian, Jian Hua Zhang, Xiu Rong Yuan, Cheng Hai Liu, Yao Wang Jin, Hai Bo Ping
Abstract: A multiphasic estrogenic/progestogenic contraceptive regimen that provides for the reduction or elimination of estrogen in the initial phase is disclosed. Also described is a contraceptive kit that may be used to practice the method of the invention.
Abstract: The present invention is directed to a patch containing a non-steroidal anti-inflammatory drug including an adhesive layer composed of a transdermal preparation on a support, the transdermal preparation including a) 10 to 40% by weight of a nonaqueous base material based on the total weight of the transdermal preparation, b) 1 to 10% by weight of a non-steroidal anti-inflammatory drug based on the total weight of the transdermal preparation, and c) a polyethylene glycol component composed of 0.3 to 5% by weight of a low molecular weight polyethylene glycol based on the total weight of the transdermal preparation, and 1 to 10% by weight of a high molecular weight polyethylene glycol based on the total weight of the transdermal preparation.
Type:
Grant
Filed:
December 4, 2012
Date of Patent:
September 15, 2015
Assignee:
Reckitt Benckiser Healthcare International Limited
Abstract: Nanoemulsions and processes for their preparation, and their use as formulations of plant protection products and/or pesticides and/or cosmetic preparations.
Type:
Grant
Filed:
August 13, 2009
Date of Patent:
September 8, 2015
Assignee:
Evonik Degussa GmbH
Inventors:
Sabine Giessler-Blank, Ralph Scheuermann, Joachim Venzmer, David Lindsay
Abstract: The invention provides a method of reducing injury to cells, tissues or organs of a body following trauma by administering a composition to the body following trauma, including: (i) a potassium channel opener or agonist and/or an adenosine receptor agonist and (ii) a local anaesthetic. Also provided is a composition for reducing injury to cells, tissues or organs of a body following trauma including: (i) and (ii). The composition may be hypertonic.
Abstract: The invention relates to nutrient compositions for agricultural applications, and methods for plant or crop growth and care. The nutrient composition comprises a potassium-based nutrient solution enriched by electrochemical treatment. In various embodiments, the potassium-based nutrient composition comprises hypochlorous acid. The present invention involves the use of the nutrient compositions or solutions, among other things, in pre-harvest and post-harvest treatments and in environmental and soil disinfection.
Abstract: A rapidly dispersing dosage form is described, which releases its active ingredients within a period of less than about ninety seconds. These dosage forms exhibit a three-dimensional shape that is retained for adequate storage but is readily dispersed in the presence of excess moisture. Also disclosed are methods of administration of a medicament and a process for the preparation of rapidly dispersing dosage forms.
Type:
Grant
Filed:
February 9, 2012
Date of Patent:
August 25, 2015
Assignee:
Massachusetts Institute of Technology
Inventors:
Jaedeok Yoo, Sandeep Kumar, Donald C. Monkhouse
Abstract: This invention relates to a 10-component stabilized synthetic honey bee brood pheromone and methods of stabilizing said pheromone by adding one or more antioxidants, thereby enabling the production and sustained use of commercial products based on that pheromone. The 11-component stabilized pheromone composition formed by adding the antioxidant tertiary-butyl hydroquinone to a synthetic blend of ethyl linoleate, ethyl linolenate, ethyl oleate, ethyl palmitate, ethyl stearate, methyl linoleate, methyl linolenate, methyl oleate, methyl palmitate and methyl stearate can be used in generic or race-specific ratios to manipulate the behavior and improve the performance of worker honey bees, resulting in overall increased vigor of the hive.
Type:
Grant
Filed:
May 5, 2010
Date of Patent:
August 18, 2015
Assignees:
OMS Investments, Inc., The Texas A&M University System
Inventors:
Tanya Pankiw, Bradley N. Metz, Norman Avelino, Jean Pierre Lafontaine
Abstract: The present invention relates to ionic compositions for promoting mucosal reciliation, particularly in the sinonasal cavity. The ionic components of the composition can include potassium, calcium, rubidium, zinc, bromide, and magnesium in an isotonic solution. In other embodiments, the ionic components of the composition can include magnesium, bromide, sulfate, sodium, and chloride.
Abstract: The present invention provides a composition for topical treatment of skin and mucosal membrane lesions comprising a synergistic combination of copper compound and hypericum perforatum extract.
Abstract: The present invention relates to ionic compositions for debriding a tissue, particularly in the sinonasal cavity. The ionic components of the composition can include potassium, calcium, rubidium, zinc, bromide, and magnesium in an isotonic solution. In other embodiments, the ionic components of the composition can include magnesium, bromide, sulfate, sodium, and chloride.
Abstract: The present invention generally relates to aqueous seed treatment formulations comprising from about 0.2 to about 15% of at least one pesticidal agent, from about 0.1 to about 0.45% of at least one graft copolymer, at least one polyvinyl alcohol (PVA), and from about 5 to about 30% of at least one plasticizer. The present invention also relates to aqueous seed treatment formulations wherein the pesticidal agents are clothianidin, metconazole, and metalaxyl.
Type:
Grant
Filed:
February 22, 2013
Date of Patent:
August 11, 2015
Assignee:
Valent U.S.A., Corporation
Inventors:
Karen S. Arthur, Frank Gonzales, Michael Seitz, Toshiya Ogawa