Patents Examined by Susan Perkins
  • Newly identified human epsilon immunoglobulin peptides and related products
    Patent number: 5274075
    Abstract: The invention includes human .epsilon. chain transmembrane anchor peptide resulting from mRNA splicing other than the C.epsilon.4 exon, the .epsilon.m1 exon, and the .epsilon.m2 exon. Two new peptides in particular have been specifically identified. These novel peptides are not present in the conventional secreted (and circulating) IgE. These peptides provide antigenic sites for antibody binding. Thus, the invention further includes antibodies to such peptide segments, as well as such antibodies conjugated to cytotoxic agents, and their use in extracorporeal or in vivo therapy.
    Type: Grant
    Filed: April 27, 1990
    Date of Patent: December 28, 1993
    Assignee: Tanox Biosystems, Inc.
    Inventor: Tse W. Chang
  • Immunogenic compositions and methods for the treatment and prevention of gastric and duodenal ulcer disease
    Patent number: 5023077
    Abstract: Immunogenic compositions useful for the treatment or prevention of gastric or duodenal ulcer disease are disclosed. The immunogenic compositions effectively operate by inducing antibodies in a subject which selectively neutralize specific peptide gastric hormones and inhibit the binding of the hormones to physiological receptors thus limiting the secretion of stomach acid. Pharmaceutical compositions comprising effective amounts of the immunogenic compositions and methods of treatment using the compositions are also disclosed.
    Type: Grant
    Filed: January 24, 1989
    Date of Patent: June 11, 1991
    Assignee: Aphton Corporation
    Inventors: Philip C. Gevas, Stephen L. Karr, Jr., Stephen Grimes, Richard L. Littenberg
  • Method of peptide synthesis
    Patent number: 4965343
    Abstract: A method for the solid phase synthesis of multi-sulfated peptides comprising coupling side-chain unprotected hydroxyamino acids to the peptide chain utilizing benzotriazol-1-yl-oxy-tris (dimethyl)-phosphonium hexafluorophosphate (BOP) as a coupling reagent.
    Type: Grant
    Filed: January 28, 1988
    Date of Patent: October 23, 1990
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Arthur M. Felix, Alain Fournier, Waleed Danho
  • Cyclic analogs of atrial natriuretic peptides
    Patent number: 4935492
    Abstract: Compounds and compositions comprising cyclic synthetic analogs of Atrial Natriuretic Peptides are provided, together with methods for their production and use as natriuretics, diuretics and/or vasodilators, or as intermediates for or modulators of such useful compounds or of native Atrial Natriuretic Peptides.
    Type: Grant
    Filed: March 29, 1988
    Date of Patent: June 19, 1990
    Assignee: California Biotechnology Inc.
    Inventors: John A. Lewicki, Robert M. Scarborough, Lorin K. Johnson
  • Physiologically-active novel peptides
    Patent number: 4904763
    Abstract: Disclosed herein is a physiologically-active peptide represented by the following general formula (I): ##STR1## wherein X means H or H-Asp-Ser-Gly- and Y denotes -Asn-Val-Leu-Arg-Arg-Tyr-OH, -Asn-Val-Leu-Arg-Arg-OH, -Asn-Val-Leu-Arg-Tyr-OH, -Asn-Val-Leu-Arg-OH, -Asn-Val-Leu-OH or -Asn-Ser-Phe-Arg-Tyr-OH, or a salt thereof.
    Type: Grant
    Filed: June 17, 1988
    Date of Patent: February 27, 1990
    Assignees: Daiichi Pure Chemicals Co., Ltd., Hisayuki Matsuo
    Inventors: Hisayuki Matsuo, Kenji Kangawa, Naoto Minamino, Tetsuji Sudoh, Atsushi Izumi, Mitsutaka Isogai