Patents Examined by Suzanne Marie Noakes
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Patent number: 10092555Abstract: Provided herein are compositions, therapeutic methods, screening methods, computational methods and biomarkers based upon the elucidation of the interaction among cereblon, its substrates and certain compounds or agents, including small molecules, peptides, and proteins.Type: GrantFiled: June 26, 2015Date of Patent: October 9, 2018Assignee: CELGENE CORPORATIONInventors: Philip Chamberlain, Brian E. Cathers, Antonia Lopez-Girona
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Patent number: 10077299Abstract: The present invention relates to a self-cleaving fusion protein including a target protein, a peptide consisting of amino acid sequence represented by LPXTG, a domain of Sortase A having cleaving function, and a tag, which are sequentially positioned from the amino terminal; a nucleic acid encoding the same; an expression vector including the nucleic acid of the present invention; and a cell transformed with the expression vector of the present invention. In addition, the present invention relates to a method for refining a target protein including culturing, dissolving, and purifying the transformed cell, and a method for preparing a therapeutic antibody-drug conjugate by using the purifying method.Type: GrantFiled: April 25, 2014Date of Patent: September 18, 2018Assignee: AbTLAS CO., LTD.Inventors: Byeong Doo Song, Jee Sun Yun, Hyo Jung Choi, Hye In Kim, Eung-Suk Lee
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Patent number: 10072150Abstract: This document describes biochemical pathways for producing 4-hydroxybutyrate, 4-aminobutyrate, putrescine or 1,4-butanediol by forming one or two terminal functional groups, comprised of amine or hydroxyl group, in a C5 backbone substrate such as 2-oxoglutarate or L-glutamate.Type: GrantFiled: December 21, 2015Date of Patent: September 11, 2018Assignee: INVISTA North America S.à r.l.Inventors: Alex Van Eck Conradie, Adriana Leonora Botes
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Patent number: 10071061Abstract: A sterile composition which comprises a protein and an aliphatic polyester containing the protein and is sterilized with radiation. In this sterile composition, the structure and function (activity) of the protein are retained.Type: GrantFiled: May 13, 2013Date of Patent: September 11, 2018Assignees: TEIJIN LIMITED, Teijin Pharma Limited, THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTEInventors: Yukako Kageyama, Kentaro Fujinaga, Ayuko Yamaguchi, Susumu Honda, Makoto Satake, Hiroaki Kaneko, Ayumi Ishiwari
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Patent number: 10065997Abstract: A polypeptide porous body of the present invention is a porous body of a polypeptide derived from spider silk proteins. The polypeptide includes a water-insoluble polypeptide. The polypeptide porous body has an apparent density of 0.1 g/cm3 or less. A method for producing the polypeptide porous body includes: a solution production step in which the polypeptide is dissolved in at least one solvent selected from DMSO, DMF, and these with an inorganic salt, so as to obtain a solution of the polypeptide; a step in which the solution produced in the solution production step is substituted with a water-soluble solvent so as to obtain a polypeptide gel; and a step in which the polypeptide gel is dried. Thereby, the present invention provides a polypeptide porous body having excellent water absorbability and a polypeptide porous body suitable for application to a living body, and a method for producing the same.Type: GrantFiled: April 18, 2014Date of Patent: September 4, 2018Assignee: SPIBER INC.Inventors: Toshiaki Osawa, Keisuke Morita
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Patent number: 10060920Abstract: The present disclosure provides, inter alia, genetically encoded recombinant peptide biosensors comprising analyte-binding framework portions and signaling portions, wherein the signaling portions are present within the framework portions at sites or amino acid positions that undergo a conformational change upon interaction of the framework portion with an analyte.Type: GrantFiled: February 26, 2018Date of Patent: August 28, 2018Assignees: Howard Hughes Medical Institute, The Brigham & Women's Hospital, Inc.Inventors: Jonathan S. Marvin, Loren Looger, Richard T. Lee, Eric Schreiter
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Patent number: 10058496Abstract: A thermosensitive ionic composite having a multistage phase transition characteristic, a method for preparing the thermosensitive ionic composite, and a biodegradable composition containing the thermosensitive ionic composite are provided.Type: GrantFiled: August 18, 2015Date of Patent: August 28, 2018Assignee: Research & Business Foundation Sungkyunkwan UniversityInventor: Yong Taik Lim
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Patent number: 10059963Abstract: The present disclosure generally relates to microorganisms that comprise one or more polynucleotides coding for enzymes in one or more pathways that catalyze a conversion of a fermentable carbon source to butadiene. Also provided are methods of using the microorganisms in industrial processes including, for use in the production of butadiene and products derived therefrom.Type: GrantFiled: October 16, 2015Date of Patent: August 28, 2018Assignee: BRASKEM S.A.Inventors: Mateus Schreiner Garcez Lopes, Avram Michael Slovic, Iuri Estrada Gouvea, Johana Rincones Perez, Lucas Pedersen Parizzi
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Patent number: 10059952Abstract: Method and system for expression systems, based on ade1 and ade2 auxotrophic strains of yeast and fungi, including P. pastoris are disclosed. The expression systems are useful for increased cellular productivity of transformed cell lines and for production of recombinant glycoproteins at industrial scale.Type: GrantFiled: August 26, 2015Date of Patent: August 28, 2018Assignee: GLYCOFI, INC.Inventor: Juergen Nett
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Patent number: 10053501Abstract: The present invention relates to a method for purifying triple-helical or collagen-like proteins recombinantly produced from a bacterial, yeast or plant host cell.Type: GrantFiled: March 21, 2014Date of Patent: August 21, 2018Assignee: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATIONInventors: John Alan Maurice Ramshaw, Jerome Anthony Werkmeister, Yong Yi Peng
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Patent number: 10047385Abstract: A method for producing an objective substance is provided. An objective substance is produced by culturing a microorganism which has been modified so that the activity of a dicarboxylic acid exporter protein is reduced in a medium, and collecting the objective substance from the medium.Type: GrantFiled: January 7, 2016Date of Patent: August 14, 2018Assignee: AJINOMOTO CO., INC.Inventors: Yoshihiko Hara, Keita Fukui, Akito Chinen, Suguru Yamakami