Patents Examined by T. A. Solola
  • Electron acceptors for polymeric thin film waveguide media
    Patent number: 6448416
    Abstract: The present invention is directed to dicyanomethylenedihydrofuran-based electron acceptors which can be used in the preparation of polymeric thin films for waveguide media, and methods of making the same.
    Type: Grant
    Filed: June 16, 2000
    Date of Patent: September 10, 2002
    Assignee: Corning Incorporated
    Inventors: Mingqian He, Thomas M. Leslie
  • Electron acceptors for polymeric thin film waveguide media
    Patent number: 6444830
    Abstract: The present invention is directed to dicyanomethylenedihydrofuran-based electron acceptors which can be used in the preparation of polymeric thin films for waveguide media, and methods of making the same.
    Type: Grant
    Filed: September 29, 2000
    Date of Patent: September 3, 2002
    Assignee: Corning Incorporated
    Inventors: Mingqian He, Thomas M. Leslie
  • Method for preparing 1-alkyl-pyrazol-5-carboxylic acid esters III
    Patent number: 6444828
    Abstract: 1-Alkyl-pyrazole-5-carboxylic esters are obtained with surprisingly low proportions of 1-alkyl-pyrazole-3-carboxylic esters if a 2,4-diketo ester and/or an enolate thereof is reacted with an alkylhydrazine and/or a corresponding alkylhydrazinium salt, if appropriate, in the presence of a solvent and/or of water, in such a manner that during at least about 90% of the reaction free alkylhydrazine is present.
    Type: Grant
    Filed: February 9, 2001
    Date of Patent: September 3, 2002
    Assignee: Bayer Aktiengesellschaft
    Inventors: Nikolaus Müller, Michael Matzke
  • Process for the preparation of phosphites
    Patent number: 6444836
    Abstract: A process for manufacturing organic phosphites of at least 95.5 wt. % purity, said process comprising: reacting a hydroxyl-containing compound with a phosphorous compound, and desorbing residual hydroxyl-containing compound in the reaction product in a desorbing column employing an inert gas as a desorbing agent.
    Type: Grant
    Filed: May 23, 2001
    Date of Patent: September 3, 2002
    Assignee: General Electric Company
    Inventors: Kief Hess, James A. Mahood, Steve Marcus, Charles E. White, Jr.
  • Optically active epoxy compound
    Patent number: 6444814
    Abstract: Optically active &bgr;-type tris-(2,3-epoxypropyl)-isocyanurate is obtained by a method of reacting isocyanuric acid with an optically active epihalohydrin, or a method of optically resolving a racemic modification of tris-(2,3-epoxypropyl)-isocyanurate by using an amylose or cellulose derivative. It is a method for producing a high melting point type tris-(2,3-epoxypropyl)-isocyanurate obtained by mixing two enantiomers of optically active &bgr;-type tris-(2,3-epoxypropyl)-isocyanurate.
    Type: Grant
    Filed: August 31, 2000
    Date of Patent: September 3, 2002
    Assignee: Nissan Chemical Industries, Ltd.
    Inventors: Hisao Ikeda, Motohiko Hidaka, Atsumi Aoki
  • IL-8 receptor antagonists
    Patent number: 6440993
    Abstract: A compound of the formula: wherein R1 and R1 and m are as defined in the specification.
    Type: Grant
    Filed: March 29, 2001
    Date of Patent: August 27, 2002
    Assignee: SmithKline Beecham Corporation
    Inventor: Katherine L. Widdowson
  • Monomeric and dimeric heterocycles, and therapeutic uses thereof
    Patent number: 6440996
    Abstract: The invention provides compounds of formula (I): X—L—X1  (I) wherein X and X1 are substituted piperidine, cyclohexane, or tetrahydropyran rings, and L is a linking group between X and X1; as well a pharmaceutical composition comprising a compound of formula I; intermediates and methods useful for preparing a compound of formula I; and therapeutic methods for treating drug addiction, Parkinson's disease, depression, or a disease wherein the administration of cocaine is indicated, comprising administering a compound of formula I or a pharmaceutically acceptable salt thereof to a mammal in need of such treatment.
    Type: Grant
    Filed: October 7, 1999
    Date of Patent: August 27, 2002
    Assignee: Georgetown University
    Inventors: Alan P. Kozikowski, Gian Luca Araldi, Amir P. Tamiz
  • Process of the preparation of chiral nicotinic, quinolinic or benzoic acid imidazolinone herbicides
    Patent number: 6441190
    Abstract: There is provided a stereospecific process for the preparation of essentially enantiomerically pure imidazolinone herbicides having the R-configuration via (R) 2-amino-2,3-dimethylbutyronitrile.
    Type: Grant
    Filed: January 14, 2002
    Date of Patent: August 27, 2002
    Assignee: BASF Aktiengesellschaft
    Inventors: Peter John Wepplo, Thomas Walter Drabb
  • Method for the preparation of 5-cyanophthalide
    Patent number: 6441201
    Abstract: A method for the preparation of 5-cyanophthalide in which 5-carboxyphthalide is reacted with a dehydrating agent, such as thionylchloride, and a sulphonamide, in particular sulfamide. Cyanophthalide is prepared in high yields by a convenient procedure. 5-cyanophthalide is an intermediate used in the preparation of the antidepressant drug citalopram.
    Type: Grant
    Filed: July 27, 2001
    Date of Patent: August 27, 2002
    Assignee: H. Lundbeck A/S
    Inventor: Beat Weber
  • Cyclopentylalkyl-nitriles
    Patent number: 6441052
    Abstract: The present invention provides compounds of formula I wherein R1 and R3 are independently H or C1-3 alkyl, and R2 is H, C1-3 alkyl, methylene or ethylidene, with the proviso that R1 and R2 are not simultaneously H; n is 0 or 1; and is a single or a double bond, wherein a maximum of two double bonds are present in the compound. Compounds of formula II are also provided: wherein A is selected from the group of CR4R5OH, CR4R5OC(O)R6, CO2R6, CN and C(O)R4; R1, R3, R4, and R5 are independently H or C1-3-allyl; R2 is H, C1-3-alkyl, methylene, or ethylidene; R6 is H, C1-3 alkyl, C2-4 alkenyl, or alkinyl; n is 0 or 1; and is a single or a double bond, wherein a maximum of two double bonds are present. Compositions containing compounds of formulae I and II, as well as methods for imparting fragrance to substrates using such compounds are also provided.
    Type: Grant
    Filed: April 12, 2002
    Date of Patent: August 27, 2002
    Assignee: Givaudan SA
    Inventors: Jerzy A. Bajgrowicz, Bernadette Bourdin Trunz, Peter Gygax
  • Method for preparing DL-&agr;-tocopherol with a high yield and high purity
    Patent number: 6441200
    Abstract: Disclosed is a method for preparing DL-&agr;-tocopherol through the condensation of isophytol or phytol derivatives and trimethylhydroquinone (TMHQ) using a catalyst system comprising a divalent metal halogen compound, silica gel and/or silica-alumina, and a Brönsted acid. Isophytol or phytol derivatives are slowly added to trimethylhydroquinone for the condensation thereof at 80 to 135° C. over 30 to 60 min in the presence of the metal halogen and the silica gel and/or silica-alumina. In the presence of the Brönsted acid, the intermediates are converted into the product. The silica gel and/or silica-alumina is washed with a polar solvent for recovery. The catalyst system can remarkably reduce side-reactions upon the condensation of isophytol or phytol derivatives and TMHQ, thus producing DL-&agr;-tocopherol with a high purity at a high yield.
    Type: Grant
    Filed: November 13, 2000
    Date of Patent: August 27, 2002
    Assignee: Sk Corporation
    Inventors: Sijoon Lee, Jeong-Soo Kim, Young-Seek Yoon, Myung-Jun Kim, Jun-Tae Choi, Byong-Sung Kwak
  • Diaminofluorescein derivative
    Patent number: 6441197
    Abstract: A compound represented by the following formula (I): wherein R1 and R2 represent amino group that substitute at adjacent positions on the phenyl ring, provided that either of R1 and R2 represents a mono(C1-6 alkyl)-substituted amino group and the other represents an unsubstituted amino group; and R3 and R4 independently represent hydrogen atom or an acyl group, and an agent for measurement of nitrogen monoxide which comprises said compound.
    Type: Grant
    Filed: January 20, 2000
    Date of Patent: August 27, 2002
    Assignees: Daiichi Pure Chemicals Co., Ltd.
    Inventors: Tetsuo Nagano, Hirotatsu Kojima
  • Method for reprocessing reaction mixtures containing diaryl carbonate
    Patent number: 6437166
    Abstract: A process for the work up of reaction mixtures containing diaryl carbonate, aromatic hydroxy compound, water, base and quaternary salt, which are obtained in the preparation of diaryl carbonates by direct carbonylation of aromatic hydroxy compounds, is described. In the process of the present invention an adduct of diaryl carbonate and aromatic hydroxy compound is crystallized from the reaction mixture. A distillate comprising aromatic hydroxy compound is removed from the liquid phase either prior to or after crystallization of the adduct of diaryl carbonate and aromatic hydroxy compound. The liquid phase remaining after the crystallization and distillation steps may be recycled, without further work up, back to the direct carbonylation process step by which the diaryl carbonate is initially prepared.
    Type: Grant
    Filed: June 14, 2001
    Date of Patent: August 20, 2002
    Assignee: Bayer Aktiengesellschaft
    Inventors: Carsten Hesse, Ursula Jansen, Johann Rechner, Claus-Peter Reisinger, Rob Eek, Kaspar Hallenberger, Martin Friedrich
  • Synthesis of sulfoxides via selective oxidation of sulfides with a perborate or a percarbonate
    Patent number: 6437189
    Abstract: The present invention provides a process for making sulfoxides from sulfides. The process includes the step of selectively oxidizing a sulfide utilizing a perborate or a percarbonate as an oxidizing agent.
    Type: Grant
    Filed: December 12, 1997
    Date of Patent: August 20, 2002
    Assignee: Bayer Corporation
    Inventors: Vidyanatha A. Prasad, Peter E. Newallis
  • Production methods of 5-phthalancarbonitrile compound and an intermediate therefor
    Patent number: 6433195
    Abstract: The present invention provides a production method of a 5-phthalancarbonitrile compound of the formula [VI] as well as production methods of a compound of the formula [V]
    Type: Grant
    Filed: November 30, 2001
    Date of Patent: August 13, 2002
    Assignee: Sumika Fine Chemicals Co., Ltd.
    Inventors: Tetsuya Ikemoto, Masami Igi
  • Branched surfactant manufacture
    Patent number: 6433207
    Abstract: Alpha-olefins are dimerized to form branched-chain feedstocks for detersive surfactants.
    Type: Grant
    Filed: September 6, 2001
    Date of Patent: August 13, 2002
    Assignee: Procter & Gamble Company
    Inventor: Daniel Stedman Connor
  • Substituted &bgr;,&ggr;-anellated lactones
    Patent number: 6433004
    Abstract: The present invention relates to novel substituted &bgr;,&ggr;-fused lactones, to processes for their preparation and to their use for the prevention and/or treatment of disorders caused by hyper- or hypofunction of the glutamatergic system, in particular of cerebral ischaemias, craniocerebral trauma, states of pain or CNS-mediated spasms.
    Type: Grant
    Filed: July 14, 2000
    Date of Patent: August 13, 2002
    Assignee: Bayer Aktiengesellschaft
    Inventors: Andreas Stolle, Horst-Peter Antonicek, Stephen Lensky, Arnd Voerste, Thomas Müller, Jörg Baumgarten, Karsten von dem Bruch, Gerhard Müller, Udo Stropp, Ervin Horváth, Jean-Marie-Viktor de Vry, Rudy Schreiber
  • Medicinal composition
    Patent number: 6429212
    Abstract: It is to provide a cyclic imide derivative which is useful as an active ingredient of a pharmaceutical composition. A pharmaceutical composition which comprises, a cyclic imide derivative represented by the general formula (I): wherein Q1 is a single bond, —CH2—, —O—, —S— or —NH—, each of Q2 and Q3 is —C(O)—, —C(S)— or —CH2—, provided that at least one of Q2 and Q3 is —C(O)— or —C(S)—, Z is a single bond or a lower alkanediyl group, R is an aryl group which may be substituted or a cycloalkyl group which may be substituted, X is a nitro group, an amino group which may be acylated, a cyano group, a trifluoromethyl group, a hydroxyl group, a halogen atom, an alkyl group, an alkoxy group or an alkylthio group, m is an integer of from 0 to 4, and when m is 2 or above, X may be the same or different, or its salt.
    Type: Grant
    Filed: February 16, 1999
    Date of Patent: August 6, 2002
    Assignee: Ishihara Sangyo Kaisha Ltd.
    Inventor: Yuichi Hashimoto
  • Treatment of chronic hypertension and related conditions with thiol complexes
    Patent number: 6429219
    Abstract: This invention relates to the synthesis of certain complexes of cysteine, N-acetylcysteine, N-(2-mercaptopropionyl)glycine, and L-2-oxothiazolidine-4-carboxylate and to the nutritional use of these and other related individual or complexed thiol-contributing glutathione predecessors. Clinical uses for these molecules and complexes in the beneficial modification of various physiological conditions and functions associated with aging, chronic glaucoma, diabetes mellitus, insulin resistance, macular degeneration, neurodegenerative diseases and vasoconstriction are described in particular.
    Type: Grant
    Filed: May 3, 2000
    Date of Patent: August 6, 2002
    Assignee: Chronorx, LLC
    Inventors: Don C. Pearson, Kenneth T. Richardson
  • Method for continuous production of propylene oxide and other alkene oxides
    Patent number: 6429323
    Abstract: Alkene oxides are produced in a continuous integrated two-,step process performed in liquid phase. Step I comprises the oxidation of a secondary alcohol with molecular oxygen to generate hydrogen peroxide at moderate temperature and pressure. This reaction mixture is introduced directly to an olefinic substrate maintained in organic solvent at elevated pressure. During step II of the procedure the olefins undergo epoxidation by the hydrogen peroxide in the presence of a catalyst of titanium-impregnated, amorphous silica. The integrated process requires no intermediate purification or enrichment step and it is particularly well adapted to the production of propylene oxide.
    Type: Grant
    Filed: June 21, 2000
    Date of Patent: August 6, 2002
    Assignee: Repsol Quimica, S.A.
    Inventors: Ma Pilar De Frutos Escrig, Ana Padilla Polo, Jose Migel Campos Martin