Abstract: A platform of devices for removing obstructions and other objects within a blood vessel or other interior lumen of an animal is provided. The system may be deployed in the lumen from a catheter(s) and the system includes a proximal hub, and a distal basket comprised of a plurality of cells. A number of different baskets designs are disclosed. Methods of manufacturing such baskets out of a single tube of a memory metal without the need for any welding, and methods of use are also disclosed.

Abstract: A suture-based vessel closure device can perform the dilation of an arteriotomy puncture and does not require previous dilation of the arteriotomy puncture by a separate device or by a procedural sheath dilator. The suture-based vessel closure device can place one or more sutures across the vessel access site such that, when the suture ends are tied off after sheath removal, the stitch or stitches provide hemostasis to the access site.

Abstract: Accordingly, embodiments of the present invention provide an IOL insertion device that facilitates the injection of the IOL in a controlled manner. The insertion device includes a front modular portion and an injector. The modular portion may be preloaded with an IOL and coupled with the injector. The injector includes a distal portion, a body, and a plunger. The distal portion includes a front seal which has a longitudinal bore at the center, through which a distal portion of the plunger passes. The plunger tip is tapered. The plunger also includes a sealing element situated between its distal portion and its proximal portion. The sealing element includes a small aperture through which a fluid, such as a viscoelastic or a balanced salt solution (“BSS”) and the like, may pass toward the proximal end of the body when the plunger advances distally. As the fluid passes through the small aperture on the sealing element on the plunger, a constant speed and force is maintained as the IOL is ejected into the eye.

Abstract: A closed loop-type hemostatic device having built-in inner pincers which integrates holding type pincers with a device for fitting a hemostatic clip, so as to: primarily, find and temporarily perform hemostasis on a bleeding portion by using holding type pincers after confirming that the bleeding portion exists; secondarily, move a clip pressing part and a clip pressing part and enclose the bleeding portion; and then move only the clip pressing part and clip a closed loop-type hemostatic clip onto the bleeding portion so as to perform hemostasis. The amount of bleeding can be reduced by temporary hemostasis on a bleeding portion, and a hemostatic clip can be precisely clipped on the bleeding portion, thereby improving hemostatic performance. Also, because hemostasis can be selectively performed only around a damaged blood vessel wall, therefore, the physiological benefit of being able to maintain partial blood flow may be provided.

Abstract: In some embodiments, a debridement tool may include a housing, a reduced-pressure lumen, a debridement head, an impeller, and a drive system. The debridement head may be moveable relative to the housing. The impeller may be positioned in fluid communication with the reduced-pressure lumen and be moveable relative to the housing by operation of reduced pressure being applied to the impeller. The drive system may be coupled between the impeller and the debridement head and be configured to impart movement from the impeller to the debridement head.

Abstract: The invention relates to a pusher assembly for an insertion system for a vascular implant. The pusher assembly has a catheter tube. The catheter tube has a tubular cavity for accommodating a guide wire and has a proximal catheter tube segment and a distal catheter tube segment adjoining the proximal catheter tube segment. The distal catheter tube segment is provided at least partially for movably accommodating a vascular implant on the distal catheter tube segment. The catheter tube also has a pusher unit for releasing the vascular implant, said pusher unit being proximally adjacent to a vascular implant loaded onto catheter tube. The pusher assembly is characterized in that the pusher unit is formed by individual, segment-like elements, which are arranged on behind the other and adjacent to each other and are arranged on the catheter tube in order to proximally adjoin the vascular implant.

Abstract: Catheter-delivered endovascular medical devices are described. The devices may include a pull wire connected to a proximal body and a distal body, which may be formed of a basket or other framework that has a plurality of cells. The distal body may move/articulate proximally relative to and toward the proximal body. Methods of using and making the devices are also described.

Abstract: A vitrectomy apparatus is provided, including a pressure source, a cut valve connected to the pressure source, the cut valve configured to be turned on and off to provide pressure to selectively extend and retract a vitrectomy cutting device, a sensor configured to sense pressure provided from the cut valve, and a controller configured to control operation of the cut valve based on pressure sensed by the sensor. The controller is configured to monitor pressures encountered and alter cut valve timing based on pressure conditions previously encountered.

Abstract: A method for maintaining the alignment of the edges of a trocar defect by inserting into a defect a device for compressing the tissue such that part of the device is above while the other is below the defect, then pulling back on the device so that the part below the defect is up against the defect, then while holding the device below the defect in place, push down on the part above the wound so that it compresses the tissue. Finally, release the device from the insertion tool.

Abstract: A method and system for placing a device enabled for endovascular navigation, specifically a PICC catheter, and more broadly any device which is manipulated in over the wire or monorail fashion. Variants of the system comprise a guidewire for navigating through a patient's vasculature, having an electromagnetic (EM) based tracking components at or near the a leading end of the guidewire; an EM positioning field generator configured on a reference gantry; a computer and display configured to output position information of the guidewire leading end; and a servomotor delivery system actuator, mechanically coupled to the guidewire and configured for controlling the position of the guidewire.

Abstract: An apparatus for insertion of a medical device in the skin of a subject is provided, as well as methods of inserting medical devices.

Abstract: A compression device, useful for applying circumferential compression to an object, for example, as a tourniquet to occlude blood flow in a hemorrhaging extremity, is provided. The device includes a buckle assembly, first and second guidance slides, a connecting member between the first and second guidance slides, and a strap. Each end of the strap is anchored to a guidance slide. From each of the anchored ends, the strap passes through the buckle assembly, forming outer segments. The strap then returns along respective insides of the outer segments and through the guidance slides, forming inner segments. The buckle assembly, inner segments and connecting member form a loop for placing about an object, an inner circumference of the loop being adjustable by pulling on a portion of the strap located along the outside of the connecting member and between the two guidance slides to tighten the loop around the object.

Abstract: Catheter-delivered endovascular medical devices are described. The devices may include a pull wire attached to a distal body, which may be formed of a basket or other framework that has a plurality of cells. The pull wire may be extra long to allow a secondary device, such as an aspiration catheter, balloon or stent, to be delivered over the pull wire while the pull wire is in an intracranial artery. Methods of using and making the devices are also described.

Abstract: Catheter-delivered endovascular medical devices are described. The devices may include a pull wire connected to a proximal body and a distal body, which may be formed of a basket or other framework that has a plurality of cells. The distal body may move/articulate proximally relative to and toward the proximal body. Methods of using and making the devices are also described.

Abstract: A platform of devices for removing obstructions and other objects within a blood vessel or other interior lumen of an animal is provided. The system may be deployed in the lumen from a catheter(s) and the system includes a proximal hub, and a distal basket comprised of a plurality of cells. A number of different baskets designs are disclosed. Methods of manufacturing such baskets out of a single tube of a memory metal without the need for any welding or soldering, and methods of use are also disclosed.

Abstract: A medical device for incising a substance inside a biological lumen. The medical device includes a tubular drive shaft that is rotatable, an intermediate portion connected to the drive shaft, at least one strut interlocked with the drive shaft, a tubular linear motion shaft inside of the drive shaft, and a tubular interlock portion. The strut is rotatable with the drive shaft and is expandable radially outward in response to outward expansion of the intermediate portion. The linear motion shaft is movable relative to the drive shaft in the axial direction to cause the strut to expand radially outward. The tubular interlock portion interlocks the drive shaft and the linear motion shaft while maintaining liquid-tight properties. The tubular interlock portion is stretchable in the axial direction.

Abstract: A medical device for incising a substance inside a biological lumen. The medical device includes a rotatable drive shaft, an outer sheath that accommodates the drive shaft, an intermediate portion connected to the drive shaft, at least one strut interlocked with the drive shaft, a linear motion shaft inside of the drive shaft, and a liquid feeding unit. The strut rotates with the drive shaft and is expandable radially outward in response to outward expansion of the intermediate portion. The linear motion shaft is movable relative to the drive shaft in the axial direction to cause the strut to expand radially outward. The liquid feeding unit supplies liquid to a space between the outer sheath and the drive shaft. The drive shaft includes a hole portion penetrating from an inner surface of the drive shaft through to an outer surface of the drive shaft.

Abstract: Embodiments of the present disclosure provide a prosthetic heart valve and a heart valve delivery apparatus for delivery of the prosthetic heart valve to a native valve site via the human vasculature. The delivery apparatus is particularly suited for advancing a prosthetic valve through the aorta (i.e., in a retrograde approach) for replacing a diseased native aortic valve. In one embodiment, a self-expanding valve comprises an expandable stent that is shaped to maintain the valve in the aortic annulus against axial without anchors or retaining devices that engage the surrounding tissue. A delivery apparatus for delivering s self-expanding prosthetic valve can be configured to allow controlled and precise deployment of the valve from a valve sheath so as to minimize or prevent jumping of the valve from the valve sheath.

Abstract: Catheter-delivered endovascular medical devices are described. The devices may include a pull wire attached to a distal body. The distal body may be formed of a basket or other lattice that has a plurality of cells and an impermeable or permeable film that prevents a clot captured by the basket from escaping distally out of the basket. Methods of using and making the devices are also described.

Abstract: Catheter-delivered endovascular medical devices are described. The devices may include a pull wire detachably connected to a distal body. The distal body may be formed of a distal body outer body comprising a basket comprised of a plurality of cells defined by a plurality of basket strips and a distal body inner body located in the interior of the distal body outer body and comprising a plurality of distal braided mesh openings formed by a plurality of woven linear strands. The distal braided mesh openings may be smaller than the cells when the device is in the relaxed state. Methods of using and making the devices are also described.