Abstract: A vascular occluding device for modifying blood flow in a vessel, while maintaining blood flow to the surrounding tissue. The occluding device includes a flexible, easily compressible and bendable occluding device that is particularly suited for treating aneurysms in the brain. The neurovascular occluding device can be deployed using a micro-catheter. The occluding device can be formed by braiding wires in a helical fashion and can have varying lattice densities along the length of the occluding device. The occluding device could also have different lattice densities for surfaces on the same radial plane.

Abstract: A system for preparing an intraocular lens (IOL) injector for receipt of an IOL. A manifold mates with an injector cartridge and easily distributes a lubricating agent to a load chamber of the cartridge. The IOL is then transferred into the load chamber. The cartridge may be rotatably coupled to the handpiece, and then converted from a preparation and load position to a delivery position. The manifold may remain external to the load chamber or fit within the load chamber and include a handle that remains outside. One or more internal channels in the manifold lead from one or more inlet ports to surfaces in the load chamber than contact the IOL.

Abstract: The present disclosure generally relates to methods and compositions for treating skin. In some embodiments, the method uses an exfoliation tool. In some embodiments, the method uses an exfoliation tool together with selected skin care agents or compositions.

Abstract: A device for repairing a heart valve includes at least one hollow inner portion, a first flexible outer portion, and a second flexible outer portion. The first flexible outer portion and the second flexible outer portion are connected to the at least one hollow inner portion. The first flexible outer portion and the second flexible outer portion each include a frame formed from a loop of metal. The frames each have a central longitudinal section formed by substantially straight parallel segments and a shaped portion that connects the substantially straight parallel segments. The first flexible outer portion and the at least one hollow inner portion are configured to compress tissue of a first heart valve leaflet therebetween. The second flexible outer portion and the at least one hollow inner portion are configured to compress tissue of a second heart valve leaflet therebetween.

Abstract: Disclosed are an auricle clamp (101) and a delivery device thereof. The auricle clamp (101) includes two parallel clamp arms (202, 302); and two springs (201, 301) located at two ends of the parallel clamp arms (202, 302) respectively and are used for connecting the two ends of the two clamp arms (202, 302) to form a closed-loop structure and providing a clamping force enabling the two clamp arms (202, 203) to be located close to each other; and at least one of the two clamp arms (202, 302) is divided into a first segment and a second segment, and the first segment and the second segment are pivotally connected or connected via a flexible material.

Abstract: A system for treating an aneurysm comprises an elongate flexible shaft and an expandable member. An expandable scaffold is disposed over the expandable member and may be expanded from a collapsed configuration to an expanded configuration. A double-walled filling structure is disposed over the scaffold and has an outer wall and an inner wall. The filling structure is adapted to be filled with a hardenable fluid filing medium so that the outer wall conforms to an inside surface of the aneurysm and the inner wall forms a substantially tubular lumen to provide a path for blood flow. In the expanded configuration the scaffold engages the inner wall of the filling structure. A tether is releasably coupled with the filling structure and the flexible shaft thereby constraining axial movement of the structures relative to each other.

Abstract: A platform of devices for removing obstructions and other objects within a blood vessel or other interior lumen of an animal is provided. The system may be deployed in the lumen from a catheter(s) and may include a strain gauge for measuring tension on the pull wire. A number of different baskets designs are disclosed. Methods of manufacturing such baskets out of a single tube of a memory metal without the need for any welding, and methods of use are also disclosed.

Abstract: A surgical cutting instrument including a first tubular member, a second tubular member, a sleeve member, a third tubular member, and an orientation member. The first tubular member includes a cutting tip. The second tubular member has a distal region forming a cutting window. The first tubular member is co-axially disposed within the second tubular member such that the cutting tip is selectively exposed at the cutting window. The first and second tubular members are co-axially disposed within the sleeve member. The third tubular member is co-axially disposed around an intermediate section of the first tubular member, an intermediate region of the second tubular member and the sleeve member. The orientation member is rotatable to transmit a rotational force applied to the orientation member to selectively rotate the second and third tubular members relative to the sleeve member to effectuate spatial rotation of the cutting window.

Abstract: Described herein is an apparatus for guiding an elongated flexible instrument, the apparatus comprising a telescoping support assembly including a plurality of support members extending along a longitudinal axis between a proximal end and a distal end. Each of the support members comprises a ring having an inner surface, an outer surface, and at least one flange. Each flange extends from the inner surface of the ring to define a central passageway extending along the longitudinal axis and having a substantially constant width, which is configured to receive the elongated flexible instrument. The assembly is configured to selectively transition from a compressed to an expanded configuration along the longitudinal axis while each support member is interlocked with at least one other support member, and is adapted to support the elongated flexible instrument as the instrument is advanced along the longitudinal axis.

Abstract: The present disclosure relates to electrically controllable surgical tools. In general, surgical devices are provided having an electrically controllable, fingered operating end for use in angiography, endovascular and/or neurological surgery. The finger(s) at the operating end can be made from ionic polymer metal composite (IPMC) material to facilitate control of the finger(s).

Abstract: A pacifier including a shield having a first side, a second side, a top portion, and a bottom portion, and a handle. The handle extends from the first side of the shield and defines a longitudinal axis. A nipple extends from the second side of the shield, wherein the nipple is inclined with respect to the longitudinal axis and extends downwardly from the longitudinal axis.

Abstract: A heart valve therapy system including a delivery device and a stented valve. The delivery device includes an outer sheath, an inner shaft, an optional hub assembly, and a plurality of tethers. In a delivery state, a stent frame of the prosthesis is crimped over the inner shaft and maintained in a compressed condition by the outer sheath. The tethers are connected to the stent frame. In a partial deployment state, the outer sheath is at least partially withdrawn, allowing the stent frame to self-expand. Tension in the tethers prevents the stent frame from rapidly expanding and optionally allowing recapture. Upon completion of the stent frame expansion, the tethers are withdrawn.

Abstract: Prosthetic heart valves described herein can be deployed using a transcatheter delivery system and technique to interface and anchor in cooperation with the anatomical structures of a native heart valve. Some embodiments of prosthetic valves described herein include an anchor portion that couples to the anatomy near a native valve, and a valve portion that is mateable with the anchor portion. In some such embodiments, the anchor portion and/or the deployment system includes one or more prosthetic elements that temporarily augment or replace the sealing function of the native valve leaflets.

Abstract: A device for closing a tissue opening includes a body extending from a first end to a second end and a first anchoring element connected to the first end of the body and a second anchoring element connected to the second end of the body. At least one of the first anchoring element and the second anchoring element is movable between an insertion configuration, in which the at least one of the first and second anchoring elements is insertable through a target tissue such that the body extends across a tissue opening to be treated, and an anchoring configuration, in which the first and second anchoring elements engage target tissue on a first side and a second side, respectively, of the tissue opening.

Abstract: A suture passer comprising: a hollow tube, said hollow tube comprising a distal end, a proximal end, and a lumen extending from said distal end to said proximal end; and a suture manipulation rod slidably received in said lumen of said hollow tube and selectively projectable out said distal end of said hollow tube, said suture manipulation rod comprising a distal end and a proximal end, said distal end of said suture manipulation rod being bifurcated into a first arm and a second arm, wherein said first arm includes a hook comprising a proximally oriented hooking surface and a return extending proximally of said hooking surface; wherein said hollow tube and said suture manipulation rod are sized so that said suture manipulation rod may capture a suture disposed adjacent to said distal end of said hollow tube and draw the suture into said lumen of said hollow tube, and further wherein, after a suture has been drawn into said lumen of said hollow tube, distal movement of said suture manipulation rod causes t

Abstract: Devices for delivering and deploying an endoluminal prosthesis are disclosed and comprise a delivery catheter, an endoluminal prosthesis disposed at a distal end portion of the delivery catheter, and a wire. The prosthesis comprises a tubular graft having at least one fenestration. The wire extends distally from a first wire end through an axial lumen of the delivery catheter and the prosthesis, and through the fenestration in the graft. The wire extends proximally through a lumen of the prosthesis and through an axial lumen of the delivery catheter towards a second wire end. Additional devices, systems, and methods are disclosed.

Abstract: Methods for delivering a prosthetic valve comprise introducing the prosthetic heart valve into a body of a patient. The prosthetic valve is mounted within a delivery sheath of a delivery apparatus in a radially compressed state. The prosthetic valve is advanced through the body to a delivery location. A motor is actuated to cause the delivery sheath to retract to expose the prosthetic valve and the prosthetic valve expands to a radially expanded state at the delivery location. The methods can also include releasing the prosthetic valve from the delivery apparatus and removing the delivery apparatus from the patient.

Abstract: The disclosed system includes a probe for mechanically cutting tissue Other components of the system include a luminally protective sheath, a microscopic end cauterizing probe, a surgical console, an identification-sensitive self-sealed cassette, and a plurality of flexible tubing lines with pinch valves thereon.

Abstract: Described herein are flexible implantable occluding devices that can, for example, navigate the tortuous vessels of the neurovasculature. The occluding devices can also conform to the shape of the tortuous vessels of the vasculature. In some embodiments, the occluding devices can direct blood flow within a vessel away from an aneurysm or limit blood flow to the aneurysm. Some embodiments describe methods and apparatus for adjusting, along a length of the device, the porosity of the occluding device. In some embodiments, the occluding devices allows adequate blood flow to be provided to adjacent structures such that those structures, whether they are branch vessels or oxygen-demanding tissues, are not deprived of the necessary blood flow.

Abstract: A delivery assembly includes a prosthetic device, a catheter shaft, a release wire, a first line, and a second line. The prosthetic device has a first arm and a second arm. The release wire extends through the catheter shaft. The first line includes a first loop. The first line extends from the catheter shaft, through the first arm of the prosthetic device, and to the release wire, where the release wire extends through the first loop. The second line includes a second loop. The second line extends from the catheter shaft, through the second arm of the prosthetic device, and to the release wire, where the release wire extends through the second loop.