Patents Examined by Thurman K. Pace
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Patent number: 6077503Abstract: A skin whitening composition includes mercaptodextran. The composition can be topically applied to the human skin and can include one or more whitening agents in combination with mercaptodextran to achieve enhanced whitening effect. A method of whitening human skin includes topically applying to the skin mercaptodextran in an amount and for a period of time sufficient to visibly whiten the skin. The method includes incorporating mercaptodextran with known whitening agents and applying to the skin in an amount and for a period of time sufficient to visibly whiten the skin.Type: GrantFiled: July 30, 1997Date of Patent: June 20, 2000Assignee: Amway CorporationInventor: Jeffrey M. Dornoff
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Patent number: 5876751Abstract: A composition comprising at least one non-steroidal antiinflammatory drug, their salts, their chirally pure forms, isomers and derivatives, analogues and adducts thereof and two drugs pitofenone hydrochloride and fenpiverinium bromide in a pharmaceutically acceptable combination.Type: GrantFiled: March 26, 1997Date of Patent: March 2, 1999Assignee: Panacea Biotec LimitedInventors: Amarjit Singh, Rajesh Jain
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Patent number: 5811127Abstract: Modified amino acids and methods for their preparation and use as oral delivery systems for pharmaceutical agents are described. The modified amino acids are preparable by reacting single amino acids or mixtures of two or more kinds of amino acids with an amino modifying agent such as benzene sulfonyl chloride, benzoyl chloride, and hippuryl chloride. The modified amino acids may form encapsulating microspheres in the presence of the active agent under sphere-forming conditions. Alternatively, the modified amino acids may be used as a carrier by simply mixing the amino acids with the active agent. The preferred acylated amino acid carrier is salicyloyl-phenylalanine. The modified amino acids are particularly useful in delivering biologically active agents, e.g., desferrioxamine, insulin or cromolyn sodium, or other agents which are sensitive to the denaturing conditions of the gastrointestinal tract.Type: GrantFiled: April 24, 1996Date of Patent: September 22, 1998Assignee: Emisphere Technologies, Inc.Inventors: Sam J. Milstein, Evgueni N. Barantsevitch
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Patent number: 5674515Abstract: A food item and method for administering medication to a subject, particularly a dog wherein the food item is a short edible tube with an interior chamber having a closed end and open end providing that the medication may be inserted into the chamber through the open end of the tube and then the open end of the tube is pinched closed. The food item is composed of foodstuffs such as meats, a congealing agent, if necessary, such as flour and water, with a percentage of water selected to maintain a consistency of the foodstuff that maintains the shape of the tube in a handling operation yet is readily deformed by pinching the open end.Type: GrantFiled: September 12, 1994Date of Patent: October 7, 1997Inventor: Humphrey Erwin Wesenhagen
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Patent number: 5126147Abstract: A multiphasic sustained release injectable delivery system is provided, as well as a method for treating humans and other mammals with that multiphasic sustained release system.Type: GrantFiled: February 8, 1990Date of Patent: June 30, 1992Assignee: BioSearch, Inc.Inventors: Loui J. Silvestri, H. Ruth Pyle
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Patent number: 5114714Abstract: Disclosed is a method of inducing and maintaining anesthesia while avoiding concomitant liability of adverse effects comprising administering by inhalation to a warm blooded animal in need of anesthesia an amount sufficient to induce and maintain anesthesia but insufficient to cause said adverse effects, of (R)-isoflurane or (R)-desflurane, substantially free of its (S)-stereoisomer. Also disclosed are novel compositions of these compounds for use in the above disclosed method.Type: GrantFiled: November 29, 1990Date of Patent: May 19, 1992Assignee: Sepracor, Inc.Inventors: James W. Young, Steven Brandt
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Patent number: 5100658Abstract: Disclosed is a unique vehicle system which provides a desirable rheology to products formulated therewith, enhanced dispersion of actives therein, and improved deposition of actives therefrom. This vehicle system comprises a primary thickening agent which is a nonionic long-chain alkylated water-soluble polymer, and a secondary thickening agent which is a water-soluble polymer having a molecular weight greater than about 20,000, preferably a natural polysaccharide, dispersed in a compatible solvent. Optionally, a rheological aid, which is a chelating agent, may be included in the vehicle system. Also, optionally, a distributing aid, which is a water-soluble polymer of either high molecular weight or strong ionic character may be included in the vehicle system. These vehicle systems are useful in cosmetic compositions which are used to deliver an active component to the skin or hair.Type: GrantFiled: July 16, 1990Date of Patent: March 31, 1992Assignee: The Procter & Gamble CompanyInventors: Raymond E. Bolich, Jr., Michael J. Norton, Glen D. Russell
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Patent number: 5084358Abstract: Composite-coated flat-rolled steel, product, method of manufacture and method of fabrication in which single or double-reduced low-carbon steel, after surface preparation, is flash-coated with tin (about 0.05 #/bb) which is alloyed with the base metal. Dichromate treatment passivates the tin-iron alloy surfaces depositing a chrome oxide layer prior to application of an organic coating (about 3 to 15 mg/in.sup.2 to each surface). Enhanced coating adhesion of the organic coating enables draw-processing of the double-reduced steel base metal substrate into unitary can bodies without damage to coating or substrate.Type: GrantFiled: March 3, 1989Date of Patent: January 28, 1992Assignee: Weirton Steel CorporationInventor: William T. Saunders
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Patent number: 4942037Abstract: A transdermal delivery system suitable for the drug (4aR-trans )-3,4,4a,5,6,10b-hexahydro-4-propyl-2H-naphth[1,2-b]-1,4-oxazin-9-ol over an extended period of time is described.Type: GrantFiled: June 2, 1988Date of Patent: July 17, 1990Assignee: Merck & Co., Inc.Inventors: Joseph V. Bondi, Alice E. Loper