Patents Examined by Thurman Wheeler
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Patent number: 11951216Abstract: Microparticles containing a core of therapeutic protein and a cortex of a biocompatible and biodegradable polymer, and methods of making and using the microparticles are provided. The extended release of a therapeutic protein from the microparticles in a physiological solution is demonstrated over an extended period of time.Type: GrantFiled: February 22, 2022Date of Patent: April 9, 2024Assignee: Regeneron Pharmaceuticals, Inc.Inventors: Hunter Chen, Scott Walsh
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Patent number: 11944701Abstract: The invention relates to the use of sphingosine-based compounds, in particular phytosphingosine compounds, in the protection of hydroxyapatite containing materials such as teeth and bone. Such compounds are especially useful in the treatment and prevention of dental caries, dental erosion, dentine hypersensitivity and tartar (dental calculus) formation. Methods and devices are also provided for preventing biofilm formation using sphingosine-based compounds. Compositions comprising sphingosine-based compounds are also provided.Type: GrantFiled: February 3, 2022Date of Patent: April 2, 2024Assignee: STICHTING VUInventors: Floris Jacob Bikker, Engelmundus Cornelis Ignatius Veerman, Marianne Valentijn-Benz, Willem Van 'T Hof
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Patent number: 11911301Abstract: A method for depositing a coating comprising a polymer and pharmaceutical agent on a substrate, comprising the following steps: discharging at least one pharmaceutical agent in a therapeutically desirable morphology in dry powder form through a first orifice; discharging at least one polymer in dry powder form through a second orifice; depositing the polymer and/or pharmaceutical particles onto said substrate, wherein an electrical potential is maintained between the substrate and the pharmaceutical and/or polymer particles, thereby forming said coating; and sintering said coating under conditions that do not substantially modify the morphology of said pharmaceutical agent.Type: GrantFiled: January 25, 2021Date of Patent: February 27, 2024Assignee: Micell Medtech Inc.Inventors: Charles Douglas Taylor, James B. McClain, Mike Cole, James P. DeYoung, Clint Smoke
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Patent number: 11896583Abstract: There is provided tinostamustine or a pharmaceutically acceptable salt thereof for use in the treatment of ovarian cancer in a patient in need thereof.Type: GrantFiled: June 13, 2018Date of Patent: February 13, 2024Assignee: Purdue Pharma L.P.Inventor: Thomas Jorg Mehrling
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Patent number: 11883513Abstract: Disclosed is a hair care composition comprising from about 0.04 wt % to about 2 wt % azelaic acid; from about 0.04 wt % to about 1 wt % oleic acid; wherein the ratio of oleic acid to azelaic acid is from about 1:1 to about 1:3.Type: GrantFiled: December 8, 2020Date of Patent: January 30, 2024Assignee: The Procter & Gamble CompanyInventors: Jennifer Mary Marsh, Timothy James Felts
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Patent number: 11857543Abstract: Provided herein are specific doses of, and dosing regimens for, using a HIF prolyl hydroxylase inhibitor in treating or preventing anemia, such as anemia secondary to or associated with chronic kidney disease, anemia associated with or resulting from chemotherapy, or anemia associated with AIDS.Type: GrantFiled: June 4, 2014Date of Patent: January 2, 2024Assignee: Akebia Therapeutics, Inc.Inventors: Robert Shalwitz, Charlotte Hartman, Akshay Buch, Isaiah Shalwitz, John Janusz, Joseph Gardner
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Patent number: 11857604Abstract: The present invention relates to the field of nanovectors for the delivery of active substances in the body, in particular for the treatment of tumours. In particular, the use of these nanovectors makes it possible to improve the pharmacokinetics of the active substances with a more selective delivery, for example in the tumour tissues.Type: GrantFiled: October 12, 2018Date of Patent: January 2, 2024Assignee: NH THERAGUIXInventors: Olivier Tillement, François Lux, Fabien Rossetti, Vu-Long Tran, Clélia Mathieu, Myleva Dahan
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Patent number: 11857592Abstract: This invention relates to a method of treating Attention-Deficit Hyperactivity Disorder by orally administering to a subject a composition containing a Radix Polygalae (Polygala tenuifolia Willd) extract (such as PDC-1421). A solid dosage form of the composition can be prepared into the gelatin capsule. The oral administration of the composition in healthy volunteers was safe and well-tolerated for the daily dose from 380 mg to 3800 mg. The composition can be administered chronically over at least 25 days; the daily dose is administered once per day, twice per day, or three times per day, wherein each dose is 380-760 mg of the botanical extract.Type: GrantFiled: December 14, 2020Date of Patent: January 2, 2024Assignee: BIOLITE, INC.Inventors: Chi-Hsin Richard King, Hsien-Ming Wu, Howard Doong, Tsung-Shann Jiang
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Patent number: 11850333Abstract: A method for depositing a coating comprising a polymer and at least two pharmaceutical agents on a substrate, comprising the following steps: providing a stent framework; depositing on said stent framework a first layer comprising a first pharmaceutical agent; depositing a second layer comprising a second pharmaceutical agent; Wherein said first and second pharmaceutical agents are selected from two different classes of pharmaceutical agents.Type: GrantFiled: April 29, 2021Date of Patent: December 26, 2023Assignee: Micell Medtech Inc.Inventors: James P. DeYoung, Charles Douglas Taylor, James B. McClain, Clint Smoke, Mike Cole
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Patent number: 11827655Abstract: The invention provides a novel class of materials that possess triplet-triplet annihilation upconversion, compositions and methods of preparation and use thereof. The invention also relates to use of such materials and nanoparticles, for example, in stimulus-responsive, in situ delivery of biologically active agents.Type: GrantFiled: July 12, 2021Date of Patent: November 28, 2023Assignee: University of MassachusettsInventors: Gang Han, Ling Huang
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Patent number: 11826426Abstract: Metal-organic layers (MOLs) and metal-organic nanoplates (MOPs) comprising photosensitizers are described. The MOLs and MOPs can also include moieties capable of absorbing X-rays or other ionizing irradiation energy and/or scintillation. Optionally, the photo sensitizer or a derivative thereof can form a bridging ligand of the MOL or MOP. Also described are methods of using MOLs and MOPs in photodynamic therapy, X-ray induced photodynamic therapy (X-PDT), radiotherapy (RT), radiodynamic therapy, or in radiotherapy-radiodynamic therapy (RT-RDT), either with or without the co-administration of another therapeutic agent, such as a chemotherapeutic agent or an immunomodulator.Type: GrantFiled: August 2, 2018Date of Patent: November 28, 2023Assignee: The University of ChicagoInventors: Wenbin Lin, Kaiyuan Ni, Guangxu Lan
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Patent number: 11806407Abstract: Described herein are compositions and methods for a novel drug delivery platform using affinity homing. Also disclosed herein are a drug delivery system, methods for using the novel drug delivery platform and a kit.Type: GrantFiled: April 5, 2019Date of Patent: November 7, 2023Assignee: UNIVERSITY OF NOTRE DAME DU LACInventors: Matthew J. Webber, Lei Zou
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Patent number: 11801222Abstract: A method for producing granules of a uniform size includes preparing an organic member solution, uniformly dispersing an inorganic member in the organic member solution at a weight ratio of 1 to 10 based on an organic member to form an organic-inorganic composite solution, spraying the organic-inorganic composite solution in an electrostatic charge manner, and polymerizing the sprayed organic-inorganic composite solution to form a hydrogel phase. The granules having a uniform size may be mass-produced in a short time and may be produced at a high yield. The method may be applied to a variety of fields, such as a pharmaceutical field, a medical field, a cosmetics field, and a food field and may replace a conventional spray drying method.Type: GrantFiled: October 10, 2019Date of Patent: October 31, 2023Assignee: KOREA INSTITUTE OF MATERIALS SCIENCEInventors: Hui Suk Yun, Honghyun Park
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Patent number: 11793876Abstract: The present invention relates to bulk dry compositions comprising polyethylene glycol and an additive, such as a flavoring agent and/or sweetener, wherein the additive remains at a consistent concentration throughout the bulk composition. The invention also relates to processes for preparing the bulk dry compositions comprising polyethylene glycol.Type: GrantFiled: October 16, 2020Date of Patent: October 24, 2023Assignee: L. PERRIGO COMPANYInventors: Lisa Kay Lupton, Kiran Kumar Muppireddy, Inderdeep Bhatia, Carlos O. Paz, Bruce D. Johnson
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Patent number: 11793910Abstract: An orthopedic implant having a metal surface and a calcium phosphate layer disposed on at least part of the metal surface is described. The calcium phosphate layer has an average crystallite size of less than about 100 nm in at least one direction and dissolves for more than 2 hours in vitro. The calcium phosphate layer is substantially free of carbonate. The coating, which is formed on a sodium titanate surface, has increased shear strength and tensile strength. The coating is formed by a solution deposited hydroxyapatite process under inert conditions. The pH of the solution varies by less than 0.1 pH unit/hour during coating formation.Type: GrantFiled: June 10, 2021Date of Patent: October 24, 2023Assignee: DEPUY SYNTHES PRODUCTS, INC.Inventors: Rajendra Kasinath, Craig Ernsberger, Stephanie Vass, Steven N. Ginn, Haibo Qu, Weidong Tong
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Patent number: 11730793Abstract: Non-aqueous emulsion methods for producing polymeric or polymer-coated microparticles are provided. One method produces a sustained release microparticle composition by combining protein powder and a polymer into a hydrocarbon solvent to form a non-aqueous first solution and adding the first solution to a second solution, wherein the second solution comprises a fluorocarbon liquid and a fluorosurfactant to form a non-aqueous emulsion comprising multiple emulsion hydrocarbon droplets in the fluorocarbon liquid. The subsequent microparticle hardening process includes the steps of removing the hydrocarbon solvent from the formed emulsion droplets, which can be achieved through evaporation the hydrocarbon at ambient condition under stirring, or accelerated hardening through vacuum, or through adding hydrofluoroester into the fluorocarbon as a cosolvent.Type: GrantFiled: November 25, 2020Date of Patent: August 22, 2023Assignee: Regeneron Pharmaceuticals, Inc.Inventors: Yiming Zhao, Hunter Chen
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Patent number: 11730725Abstract: The present invention relates to pharmaceutical tablet compositions comprising the compound niraparib as an active pharmaceutical ingredient, suitable for oral administration as well as to methods for their preparation. Also described herein are tablet compositions containing niraparib formed by the disclosed methods, and therapeutic uses of such tablet compositions for treating various disorders and conditions.Type: GrantFiled: September 26, 2018Date of Patent: August 22, 2023Assignee: Tesaro, Inc.Inventors: Simon McGurk, Padma Narayan, Aleksandar Rajlic
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Patent number: 11717471Abstract: The present application provides hydrogel microcapsules, particularly, canonized hydrogel microcapsules having improved substantivity. This application further relates to the use of hydrogel microcapsules for delivering encapsulated actives in a wide range of industries and applications including: agrochemicals, pharmaceuticals, cosmetics industry, personal care products, laundering detergents, homecare & cleaning products, dish washing detergents, oral care, dental care, textiles, paper, mining, oil industry, water treatment, adhesives, coatings, plastics, sealants, construction, paints, inks and dyes onto different substrate surfaces such as skin, hair, textiles.Type: GrantFiled: December 1, 2011Date of Patent: August 8, 2023Assignee: ISP Investments LLCInventors: Kishor Kumar Mistry, Abdul Wahab Hussain, Petra Helga Beck, David Vaughan Palmer, Benjamin Roger Sales, Andrew Mint
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Patent number: 11679984Abstract: A colloidal dispersion of particles of silica having a particle size of from 3 nm to 100 nm, to which ions of one or more metals are adsorbed, selected from metals having atomic numbers 21-31, 39-46, 48-50, 57-82, and 89-93, and a method for preparing the dispersion. The dispersion may be used in various fields of use of metals.Type: GrantFiled: June 15, 2017Date of Patent: June 20, 2023Assignee: PREBONA ABInventor: Jan-Erik Otterstedt
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Patent number: 11674107Abstract: The invention relates to the process for producing an microemulsion system of nano essential oil, the process comprising the following steps: (i) preparing a dispersed phase of essential oil; (ii) preparing of a carrier formed from a mixture of diethylene glycol monoethyl ether and lecithin; (iii) adding the carrier to the dispersed phase while keeping the dispersed phase temperature between 60 and 100° C. after addition of the carrier, while simultaneously stirring under vacuum; then pass the entire solution mixture through the system of high-pressure homogeneous machine integrated dispersion nozzle; (iv) adding the solution mixture obtained in step (iii) to Capryol 90 while keeping the mixture temperature between 60 and 100° C., and stirring at a rate ranging from 400 up to 800 rpm under vacuum; (v) cooling the mixture, homogenizing the mixture by ultrasonication to achieve a droplet size smaller than 100 nm.Type: GrantFiled: March 31, 2020Date of Patent: June 13, 2023Inventors: Hong Ngoc Thi Dang, Nam Hai Lai