Abstract: An eye-implantable device including an electrowetting lens is provided that can be operated to control an overall optical power of an eye in which the device is implanted. A lens chamber of the electrowetting lens contains first and second fluids that are immiscible with each other and that differ with respect to refractive index. By applying a voltage to electrodes of the lens, the optical power of the lens can be controlled by affecting the geometry of the interface between the fluids. One or both of the fluids can have a melting point slightly below body temperature. Freezing such an oil or other fluid of the lens can prevent fouling of internal surfaces of the lens due to folding or other manipulation of the lens during implantation. Once implanted, the fluids are melted by body heat such that the optical power of the lens may be controlled.

Abstract: An endoluminal graft includes a tubular graft material having a closed sleeve integral with the tubular graft material. The closed sleeve extends a distance along the tubular graft material. A length of wire extends at least partially along the distance and is enclosed by the sleeve. The tubular graft material and the sleeve may comprise a single piece of graft material. The sleeve may be a closed circumferential sleeve and/or a closed longitudinal sleeve.

Abstract: An intraluminal vascular prosthesis assembly, having a hollow cylindrical body with a first end and a second end is provided. The assembly includes, at its first end, a first vascular prosthesis portion, and at its second end, a second vascular prosthesis portion which has only a prosthesis material. The vascular prosthesis assembly has a stent portion which is provided between the first vascular prosthesis portion and the second vascular prosthesis portion, the stent portion being free of prosthesis material to allow fluid flow there through and received within the aortic arch and spanning the brachiocephalic artery, left common carotid artery, and left subclavian artery when placed within the aortic arch of a patient.

Abstract: An intraluminal vascular prosthesis assembly, having a hollow cylindrical body with a first end and a second end is provided. The assembly includes, at its first end, a first vascular prosthesis portion, and at its second end, a second vascular prosthesis portion which has only a prosthesis material. The vascular prosthesis assembly has a stent portion which is provided between the first vascular prosthesis portion and the second vascular prosthesis portion, the stent portion being free of prosthesis material to allow fluid flow there through and received within the aortic arch and spanning the brachiocephalic artery, left common carotid artery, and left subclavian artery when placed within the aortic arch of a patient.

Abstract: The present invention relates to a stent that uses a shape memory alloy wire, the stent being an expansion device installed on a part of a body lumen, which is constricted, or which has been constricted, so as to widen the passage of the lumen in response to the lesion part. The purpose of the present invention is to provide a method for manufacturing a stent using a shape memory alloy wire such that the stent maintains a high degree of conformability in a bent portion of a body lumen in which the same is inserted while substantially improving rigidness and durability against continuously applied fatigue, a stent manufactured thereby, and a jig for manufacturing the same.

Abstract: An implantable prosthetic valve includes a radially collapsible and radially expandable annular frame. The frame includes an annular main body sized to be implanted within a native mitral valve annulus. The frame also includes an atrial sealing member coupled to and extending radially away from the main body. The atrial sealing member is sized to extend over tissue of the native mitral annulus within a left atrium to reduce paravalvular leakage. The atrial sealing member includes an inner zig-zag portion and an outer zig-zag portion. The inner zig-zag portion and the outer zig-zag portion are connected to the main body portion only via a fabric to enhance flexibility of the atrial sealing member relative to the main body. The prosthetic valve also includes a valve member disposed within an interior of the frame.

Abstract: A heart valve replacement device for endovascular repair is provided. The heart valve replacement device includes a plurality of fibers for creating a seal with an anatomy of the patient. A heart valve is carried by an inner graft covering.

Abstract: An ophthalmic lens to be attached in or near an eyeball includes a first region that is near an optical axis; a second region that is farther from the optical axis than the first region; and a third region that is farther from the optical axis than the second region, the first region applies a first phase difference of 3 rad or more of a third phase difference with respect to the third region; the second region applies a second phase difference continuously connecting phase differences of the first region and the third region, and continuously changing in accordance with a distance from the optical axis; and the third region applies the third phase difference varying in accordance with the distance from the optical axis around a reference value, wherein a variation amplitude of the third phase difference is not less than 0.1 rad and less than the first phase difference.

Abstract: A method and system provide an ophthalmic lens including a lens body having a chamber therein, a reservoir module coupled with the lens body and an optical fluid. At least part of the lens body is flexible. The reservoir module includes a reservoir and a heat sensitive portion bordering the reservoir. The reservoir has a reservoir volume and is fluidically connected with the chamber. The heat sensitive portion has a shape responsive to a temperature of at least forty five degrees Celsius such that the reservoir volume changes in response to at least part of the heat sensitive portion reaching the temperature. The optical fluid resides in the chamber and the reservoir. A change in the reservoir volume flows a portion of the optical fluid between the reservoir and the chamber such that the flexible portion of the lens body undergoes a shape change corresponding to a base power change.

Abstract: This disclosure relates compositions comprising upconverting core-shell nanocrystals and photoactive compositions and methods using these compositions to modify treat myopia and other ocular conditions. In some cases, the methods use near infrared irradiation to adjust the refractive power of light adjustable intraocular lenses.

Abstract: An intraluminal vascular prosthesis assembly, having a hollow cylindrical body with a first end and a second end is provided. The assembly includes, at its first end, a first vascular prosthesis portion, and at its second end, a second vascular prosthesis portion which has only a prosthesis material. The vascular prosthesis assembly has a stent portion which is provided between the first vascular prosthesis portion and the second vascular prosthesis portion, the stent portion being free of prosthesis material to allow fluid flow there through and received within the aortic arch and spanning the brachiocephalic artery, left common carotid artery, and left subclavian artery when placed within the aortic arch of a patient.

Abstract: A mask is provided that is configured to increase the depth of focus of a patient. The mask can include an aperture configured to transmit along an optical axis substantially all visible incident light. The mask can further include a portion surrounding at least a portion of the aperture. The portion may be configured to be substantially opaque to visible electromagnetic radiation and be substantially transparent to electromagnetic radiation transmitted from an ocular examination device (e.g., substantially transparent to at least some non-visible electromagnetic radiation with a wavelength between about 750 nm and about 1500 nm).

Abstract: The present disclosure provides stents, particularly self-expanding stents, useful for the GI tract, and more particularly, useful for treating esophageal strictures. The stents provided herein include a medial region and proximal and distal cuffs having external diameters greater than the medial region diameter when the stent is in the deployed state. The medial region comprises an open weave wire construction. An elastomeric coating circumscribes the medial region, while the may be an extension of the wire construction or separate elements. Preferably, the cuffs have a textured surface for contact with the esophageal wall tissue to resist stent migration. The elastomer coated medial region provides a barrier to tissue ingrowth, and has an enhanced radial restoring force to maintain an open passageway in a body lumen. Optionally, the stent includes an exterior sheath with a surface pattern, to which the stent couples.

Abstract: An ophthalmic device includes an enclosure that is compatible for wearing in or on an eye. An adjustable lens is disposed within the enclosure. Driver circuitry is disposed within the enclosure and coupled to drive the adjustable lens and change its optical power. Built-in-self-test (BIST) circuitry is disposed within the enclosure and coupled to the adjustable lens. The BIST circuitry includes an impedance measurement circuit coupled to selectively measure an impedance of the adjustable lens. A controller is disposed within the enclosure and includes BIST control logic that measures the impedance of the adjustable lens with the impedance measurement circuit to determine a health status of the adjustable lens.

Abstract: An intraocular lens focuser (114) to be implanted in a human eye includes a resiliently deformable force applicator (140) to apply a focussing force to an accommodating intraocular lens and an attaching portion configured to enable attachment of the lens focuser in the eye. The force applicator is configured such that, in use, when a ciliary muscle of the eye is relaxed to place the accommodating intraocular lens in a distance vision condition, the force applicator is in a deformed condition and when the ciliary muscle contracts to place the accommodating intraocular lens in a near vision condition the force applicator resiles towards a relaxed non-deformed condition to at least assist in placing the accommodating intraocular lens in the near vision condition.

Abstract: Provided herein are implantable devices, such as vascular grafts and access port for hemodialysis, that include a microporous sheath layer having a corrugated outer surface, and use therefore for reducing the risk of infection or stenosis.

Abstract: The invention relates to the field of ophthalmic systems and procedures. In particular, the invention relates to the determination of the post-operative position of an intraocular lens (termed “IOL”) in an eye of a patient undergoing lens replacement surgery, which involves determining the position of the existing crystalline lens in the pre-operative eye of the patient and using that information and a single numerical constant to predict the post-operative intraocular lens position. Related methods, and computer programs for performing the methods of the invention, are also disclosed.

Abstract: Ophthalmic implants and methods of use that provide structural support to the optic nerve are disclosed herein. An adhesive and/or ophthalmic implant may be delivered to an optic nerve of an eye to relieve pressure on the optic nerve. The ophthalmic implant may include a base portion that includes a first surface and a second surface opposing the second surface and a protrusion from the second surface for extending into a cup of an optic nerve in an eye.

Abstract: A lumen woven support (100), comprising a netted tube body (10) woven by weaving filaments (1), wherein the netted tube body (10) comprises a first portion (110) and a second portion (120) along an axial direction; the netted tube body (10) further comprises a plurality of first hooked and wound knots (140), at least two weaving filaments (1) from one end of the second portion (120) are hooked and wound to each other in the axial direction of the netted tube body (10) to form a first hooked and wound knot (140) and are then separated, and all the weaving filaments (1) constituting the first hooked and wound knots (140) are woven to form the first portion (110); and the mesh density of the first portion (110) is smaller than that of the second portion (120).

Abstract: An accommodating intraocular lens (AIOL) for implantation within a capsular bag of a patient's eye comprises first and second components coupled together to define an inner fluid chamber and an outer fluid reservoir. The inner region of the AIOL provides optical power with one or more of the shaped fluid within the inner fluid chamber or the shape of the first or second components. The fluid reservoir comprises a bellows region with one or more folds of the bellows extending circumferentially around an optical axis of the eye. The bellows engages the lens capsule, and a compliant fold region between the inner and outer bellows portions allows the profile of the AIOL to deflect when the eye accommodates for near vision. Fluid transfers between the inner fluid chamber and the outer fluid reservoir to provide optical power changes when the eye accommodates.