Abstract: The invention provides chip packaging and processes for the assembly of retinal prosthesis devices. Advantageously, photo-patternable adhesive or epoxy such as photoresist is used as glue to attach a chip to the targeted thin-film (e.g., parylene) substrate so that the chip is used as an attachment to prevent delamination.

Abstract: A prosthetic apparatus includes a main body having a lumen and configured for placement within a native annulus of a native valve complex. The main body is radially compressible to a radially compressed state for delivery into the heart and self-expandable from the compressed state to a radially expanded state. The apparatus also includes at least one arm coupled to and disposed outside of the main body. The arm being coupled to the main body such that when the main body is compressed to the compressed state, a leaflet-receiving space between the arm and an outer surface of the main body increases to receive a native valve leaflet therebetween, and when the main body expands to the expanded state in the absence of any radial inward forces on the main body or the arm, the space decreases to capture the leaflet between the outer surface of the main body and the arm.

Abstract: Gluteal implants and gluteal implant systems are described herein, as are methods of manufacturing and implanting the same. In certain embodiments, the gluteal implant includes a body having a convex upper surface, a concave lower surface, and an edge, the edge being formed by the intersection between the convex upper surface and the concave lower surface. The body can take on various shapes, including a truncated ovoid shape, a truncated approximate ovoid shape, a truncated substantially ovoid shape, a truncated ellipsoid shape, a truncated approximate ellipsoid shape, or a truncated substantially ellipsoid shape, among others. In certain embodiments, the gluteal implant system includes first and second gluteal implants that have the same or different shaped bodies. In certain embodiments, the gluteal implants and gluteal implant systems are implanted in a buttock region.

Abstract: A stent is formed from a wire that in cross-section includes an outer member having a lumen and a radiopaque core member partially filling the lumen. A substance for elution through openings formed through the outer member fills the portion of the lumen not filled by the radiopaque core member. In a method of forming the stent, a composite wire including an outer member and a dual core member is shaped into a stent pattern. The dual core member includes a first core member and a second, radiopaque core member. The shaped composite wire is processed to remove the first core member from the outer member without adversely affecting the outer member and the second core member. The portion of the lumen that was occupied by the first core member may be filled with a substance for elution through openings from through the outer member to the lumen.

Abstract: The invention provides an intra ocular lens structure (IOL) for placement in the capsular bag and securing the IOL in an opening in an anterior part of a capsular bag, with an anterior capsular bag flap surrounding said opening, said IOL having an anterior side which in use when the IOL is implanted in an eye is directed towards a cornea of the eye, and a posterior side which in use when the IOL is implanted in an eye is directed towards a retina of the eye, said IOL comprising an optical structure, at least two posterior supports for when the IOL is implanted in the capsular bag residing in the capsular bag extending away from said optical structure, said posterior supports adapted for in use providing support surfaces for a posterior surface of an anterior capsular bag flap, and at least two anterior supports for when the IOL is implanted in the capsular bag residing outside the capsular bag extending away from said optical structure, said anterior supports adapted for in use providing support surfaces for

Abstract: A hair implant includes at least two strands including at least one of mammalian hair and synthetic hair; and an anchor, which: (a) includes silicone, (b) is configured for subcutaneous implantation, (c) includes a fracture line configured to facilitate fracturing of the anchor along the fracture line for ease of removal of the implant after subcutaneous implantation, and (d) is configured to provide a scaffold for collagen growth after subcutaneous implantation, wherein at least one of the at least two strands is joined to the anchor on one side of the fracture line and at least one of the at least two strands is joined to the anchor on an opposite side of the fracture line such that each fragment formed by fracturing the implant includes at least one of the at least two strands. Looped implants, a hair restoration method and an implant manufacturing method are also disclosed.

Abstract: Corneal implant applicator devices and methods of using. In some embodiments they include an implant applicator and an implant support, wherein the implant applicator and implant support are disposed relative to one another to form an implant nest that is adapted to house a corneal implant; wherein the applicator has a greater affinity for the corneal implant than the support.

Abstract: A method, system and apparatus for vision correction are disclosed. The method, system and apparatus include a toric intraocular element for correcting astigmatism and having a cylinder power, and a depth of focus extender coupled to the toric intraocular element, the depth of focus extender extending a depth of focus. The extended depth of focus may reduce sensitivity of the toric intraocular element to at least one of rotation and selected cylinder power.

Abstract: A keratoprosthesis and system and method of using same for corneal repair. The keratoprosthesis comprises a biocompatible support and an optic member disposed through a channel within the support. The support includes metal, preferably titanium, and treated, such as by sandblasting and/or acid etching, to create textured surfaces that promote soft tissue adhesion. A locking member interconnects the optic member and support. An outer surface of the locking member a collar extending from the support and disposed around the optic member is also metal, preferably titanium, and is similarly treated to promote soft tissue adhesion. A locking member interconnects the optic member and support. The system includes the keratoprosthesis positioned within an isolated soft tissue segment of a non-ocular tissue, such as buccal mucosa, placed on the anterior cornea.

Abstract: A haptic supporting an intraocular lens (IOL) in the eye permits radial tension from ciliary muscle relaxation rather than contraction to alter the lens power. The IOL is supported by the overlying tissue in the eye such as iris root, sclera and ciliary process, so that anterior and posterior forces on IOL are balanced, and buckling or displacement of lens in the eye or haptic is reduced or prevented. The haptic is of a thickness so as to increase stiffness and to reduce or prevent IOL buckling or displacement.

Abstract: An intraocular lens (IOL) system includes an active lens element to provide dynamic optical power for active accommodation. The active lens element has mechanical indentations disposed along a perimeter of the active lens element and the mechanical indentations form structurally weakened locations in the active lens element. A first pair of the mechanical indentations defines terminal ends of a first folding line extending between the first pair of the mechanical indentations, and the first pair of the mechanical indentations promotes folding of the active lens element along the first folding line. The IOL system also includes control circuitry coupled to the active lens element to control the active lens element during the active accommodation.

Abstract: A therapeutic lens for the treatment of an epithelial defect comprises a layer of therapeutic material disposed over the stroma and/or Bowman's membrane to inhibit water flow from the tear liquid to the stroma and/or Bowman's membrane, such that corneal deturgescence can be restored to decrease corneal swelling and light scattering. The layer may cover and protect nerve fibers to decrease pain. The layer may comprise an index of refraction to inhibit light scatter from an anterior surface of the stroma and/or Bowman's membrane. The lens may comprise a curved anterior surface that provides functional vision for the patient when the epithelium regenerates. The layer of therapeutic material can be positioned on the eye in many ways, for example with a spray that is cured to adhere the layer to the exposed surface of the stroma and/or Bowman's membrane.

Abstract: An IOL includes a fluid optic body having a cavity defined by a sidewall, a deformable optical membrane intersecting the sidewall around an anterior circumference of the sidewall, and a posterior optic intersecting the sidewall around a posterior circumference of the sidewall. The posterior optic includes a central protrusion extending anteriorly into the cavity and the deformable optical membrane includes a ring-shaped protrusion extending posteriorly into a space between the sidewall and the central protrusion. A second optic body is spaced apart from the fluid optic body and coupled thereto via a plurality of struts. Axial compression causes the plurality of struts to deform the sidewall in a manner that increases the diameter of the cavity, modifying a curvature of the deformable optical membrane is modified. Contact between the ring-shaped protrusion and the central protrusion defines a maximum modification to the curvature of the deformable optical membrane.

Abstract: An intraocular lens (IOL) has an optic, a peripheral rim, and a reduced thickness region connecting the optic to the peripheral rim. The peripheral rim has a continuously curving outer edge that it does not include any tangents parallel to the optical axis either along its length or at the intersection of the outer edge with the anterior or posterior surfaces of the IOL.

Abstract: An artificial retinal prosthesis system comprises an extraocular optical device and an intraocular retina chip. The extraocular optical device receives an external image, converts it into an optical pulse signal, and generates light energy. The intraocular retina chip receives the optical pulse signal from the extraocular optical device and produces an electric simulation signal. The intraocular retina chip includes a solar cell module receiving and converting the light energy into electric energy as a power source of the intraocular retina chip. The artificial retinal prosthesis system uses an optical modulation method to convert an image signal into an optical pulse signal, transmits the optical pulse signal into the eyeball, and decodes the optical pulse signal intraocularly. Thereby, the signal light intensity is improved without affect the contrast ratio.

Abstract: An eye lens including an optical part, which has a first optical side and an opposite second optical side with respect to a direction of an optical principal axis (A) of the eye lens, wherein a toric refractive surface profile is formed on at least one of the two sides, wherein the eye lens has a surface structure that is stepped in a radial direction of the optical part in addition to the toric refractive surface profile, and the stepped surface structure is formed on at least one side.

Abstract: An intraocular lens comprises a flexible optic and at least one haptic connected to the optic. The at least one haptic comprises a rigid structure.

Abstract: The present invention includes a device and method for treatment of retinal detachment, ocular hypertension and glaucoma, and increasing an amplitude of accommodation. The device includes a tapered, mesh tube that within a sclera, expands to deform the sclera, and when placed within the posterior sclera for the treatment of a retinal tear, the device expands deforming the sclera so that the retinal pigment epithelium comes in contact with the retinal tear to seal the tear. For the treatment of ocular hypertension, glaucoma and to increase the amplitude of accommodation, the device is placed within the anterior sclera over the posterior plicata of the ciliary body, which upon expansion causes the underlying ciliary body to deform, resulting in traction on the trabecular meshwork and deformation of the ciliary body, which causes lowering of intraocular pressure, and increases the amplitude of accommodation in patients with ocular hypertension or decreased accommodation.

Abstract: A bioabsorbable stent comprises a plurality of struts interconnected by a plurality of curved intersections. Each of the plurality of curved intersections defines a crescent shaped opening therethrough. The stent has a manufactured state, a crimped state and an expanded state. The crescent shaped openings each have a width and a length such that in the crimped state the width of the crescent shaped opening is less than the width of the crescent shaped opening in the manufactured state or the expanded state.

Abstract: An apparatus, system and method for coating an implantable lens. The apparatus, system and method may include at least one coating layer applied to at least one surface of the optic of the implantable lens, wherein the coating layer at least partially protects the optic at least during the implantation, and wherein the coating layer is removable following implantation. The coating layer may include a lubricant and/or medication and may be in the form of a biodegradable polymer and/or a film.