Abstract: The invention includes a toothpaste or other orally applied product to be used at least once daily to help prevent or inhibit the acquisition of a number of infections by oral or pharyngeal tissues, particularly including the “common” cold. These compositions possess a combination of ingredients that is not found in other toothpastes or other orally applied products, and these ingredients work together to synergistically interfere with the acquisition of a number of pathogens. The toothpastes will have the usual dentifrice ingredients known to prevent tooth decay, as well as those that reduce halitosis (i.e., bad breath), and prevent gingivitis. In addition, the toothpastes will include one or more of: 1) GALALCOOL® as an individual compound, and not as an extract component; 2) zinc protoporphyrin IX; and 3) one or more other colorless or low-color tannin(s) each as an individual compound, and not as an extract component.

Abstract: According to various embodiments of this disclosure, pharmaceutical compositions comprising solubilized estradiol are provided. In various embodiments, such compositions are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.

Abstract: The present invention relates to non-toxic consumable compositions and formulations comprising chelator and base having synergistic effects on microbial metabolism and/or growth and/or pathogenic effectors and their use to promote and maintain health in mammals. The current invention also relates to non-toxic consumable compositions comprising more than one chelator and/or more than one base. The present invention further relates to methods for selecting said chelator and base composition and methods for detecting conditions in which selected compositions may be used. The present invention relates to the synergistic compositions and methods of their use for maintaining health, promoting health and treating diseases.

Abstract: A method for making a composition for enamel regeneration proposes to encapsulate soluble calcium and phosphate salts within corresponding internal water phases in respective water-in-oil-in-water emulsions stabilized by solid particles, and add them to a toothpaste, enamel restoring gel or mouth wash base. In this way, the soluble calcium and phosphate salts can be present stably in the toothpaste, enamel restoring gel or mouth wash over a long period of time. When the toothpaste, enamel restoring gel or mouth wash of the present disclosure is used in oral cavity, the water-in-oil-in-water emulsions rapture under the effect of friction and pressing, releasing the soluble calcium and phosphate salts encapsulated within the corresponding internal water phases. As a result, the liquid in the user's oral cavity will contain high concentrations of calcium and phosphate ions, which can enhance the rate of enamel remineralization.

Abstract: The present invention relates to gel cream anti-aging cosmetic compositions in the form of an oil-in-water emulsion comprising sensory ingredients that are suitable for the complete treatment of the skin and also provide specific benefits for day and night care, which complement each other.

Abstract: An oral cleaning composition in ingestible tablet or powder formulation contains natural materials. It has an advantage of portability because it is provided in a tablet or powder form instead of a liquid or gel form. In addition, the composition does not contain synthetic chemical components but uses only natural materials and can be safely ingested after use, and, thus, it does not require a space where it can be spit out. Furthermore, it exhibits excellent efficacy in inhibiting oral bacteria and removing bad breath.

Abstract: A semi-permanent colorant composition is provided that is exhibits excellent color deposit without heat or oxidative treatment, and resists fading throughout several washes.

Abstract: The present invention provides a stabilized hypohalous acid solution (or formulation thereof), which may be conveniently packaged for sale, or stored for later use on demand. The invention further provides methods of making the stabilized hypohalous acid solution, as well as methods of use for disinfecting mammalian tissue, including wounds and burns, disinfecting or cleansing surfaces, or treating and/or preserving food products and cut flowers, among other uses.

Abstract: The present disclosure provides an oral liquid composition comprising valsartan with enhanced solubility and stability. Also, provided herein are methods of using the oral liquid compositions for the treatment of hypertension, treatment of heart failure and reduction of cardiovascular mortality in clinically stable patients with left ventricular failure or left ventricular dysfunction following myocardial infarction.

Abstract: The present invention provides a dental hydraulic temporary sealing material composition on which a protection of tooth substance, such as tooth substance strengthening and control of secondary dental caries, can be expected by sustained-releasing various ions including a fluoride ion, while having a high initial setting ability. More specifically, the present invention provides a dental hydraulic temporary sealing material composition comprising 65.0% to 85.0% by mass of component (1): a hydraulic inorganic powder; 10.0% to 25.0% by mass of component (2): an organic solvent; 3.0% to 15.0% by mass of component (3): a resin; and 0.01% to 10.0% by mass of component (4): an ion sustained-release glass.

Abstract: Oral care compositions with silica particles and stannous fluoride with an improved tin compatibility are disclosed. Oral care compositions with silica particles and stannous fluoride with a low level of an additional tin compound are disclosed. Oral care compositions with substantially spherical silica particles are disclosed.

Abstract: Collagen matrix granulate blend, and process for making and using a collagen matrix or granulate blend including collagen and particles of a biphasic calcium phosphate/hydroxyapatite (CAP/HAP) bone substitute material having a sintered CAP core and having its total external surface covered by at least one closed epitactically grown layer of nanocrystalline HAP deposited on the external surface of the sintered CAP core, whereby the epitactically grown nanocrystals have the same size and morphology as human bone mineral, wherein the closed epitactically grown layer of nanocrystalline HAP is transformed from the CAP on the external surface of the sintered CAP core has a non-homogeneous external surface comprising individual clusters of flat crystal platelets consisting of epitactically grown HAP nanocrystals and coarse areas between the individual clusters, whereby the percentage of the coarse areas between the individual clusters as measured by SEM is at least 20% of the total surface.

Abstract: A biphasic calcium phosphate/hydroxyapatite (CAP/HAP) bone substitute material having a sintered CAP core and a closed epitactically grown layer of nanocrystalline HAP deposited on the external surface of the sintered CAP core, wherein the closed epitactically grown layer of nanocrystalline HAP deposited on the external surface of the sintered CAP core has a homogeneous coarse external surface comprising flat crystal platelets, which shows an enhanced osteogenic response, a method of promoting bone formation, bone regeneration and/or bone repair by implanting the biphasic calcium phosphate/hydroxyapatite (CAP/HAP) bone substitute material, and a process of preparation thereof.

Abstract: This invention relates to a oral care compositions, and in particular to oral care mouthrinse compositions comprising (i) at least one source of ionic tin; and (ii) an antibacterial system comprising caprylyl glycol and 3-phenyl-1-propanol, as well as to methods of using and of making these compositions.

Abstract: Topical pharmaceutical compositions for treating a skin condition or disorder are provided. The topical pharmaceutical compositions can be formulated as lotions containing a therapeutically effective amount of an active agent, such as tretinoin, a viscosity increasing agent, and advantageously small amounts of both a polymeric emulsifier and an oil component. The topical compositions of the present invention are tolerated exceptionally well by subjects to whom the compositions are administered.

Abstract: A topical copper ion treatment in basic form comprises a copper ion-containing solution composed of a biocompatible solution containing copper ions obtained by leaching of the copper ions from copper metal into the solution. The copper ion-containing solution can be combined with various carriers to form various forms of the copper ion treatment including creams, gels, lotions, foams, pastes, tampons, solutions, suppositories, body wipes, wound dressings, skin patches, and suture material. A method of making the copper ion-containing solution involves placing solid copper metal in a quantity of a biocompatible solution and maintaining the solution at a specified temperature for a predetermined period of time during which copper ions leach from the copper metal into the solution, and thereafter separating the solution from the solid copper metal.

Abstract: An aqueous, intra-oral, transparent nanoemulsion blend in the form of a stable dispersion delivers both oil- and water-soluble components of a vitamin supplement in the desired concentrations to the cells of a mammal when orally administered. The transparent nanoemulsion blend includes at least two different bilayer water-core liposome components and at least one monolayer surfactant bound particle component. The transparent nanoemulsion blend optionally may include a micelle formed from phosphatidylcholine (PC).

Abstract: A dental formulation including: a bioactive glass composition as defined herein, in an effective amount; and a suitable carrier as defined herein, in an effective amount. Also disclosed is a method of making and using the dental formulation to treat, for example, dentin sensitivities.

Abstract: Provided herein are topical formulations containing copper ions and methods of treating inflammatory, microbial, and arthritic conditions in various areas of the body using such formulations. Methods of treating osteoarthritis using topical copper ion treatments are provided. Methods of treating and preventing microbial infections using copper ion treatments are further provided, including methods of preventing biofilm. A topical treatment in its basic form comprises a biocompatible copper ion solution or suspension obtained by leaching of the copper ions from copper metal. The copper ion solution or suspension is combined with various carriers to form the copper ion treatment including creams, gels, lotions, foams, pastes, tampons, solutions, suppositories, body wipes, wound dressings, skin patches, and suture material. Methods of making the copper ion solution or suspension from solid copper metal in a biocompatible solution are also provided.

Abstract: This invention relates to oral care compositions comprising arginine or lysine, zinc citrate and zinc oxide, fluoride source, and a silica abrasive which exhibits an acid pH when measured as an aqueous slurry as well as to methods of using and of making these compositions.