Patents Examined by Valerie Toodle
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Patent number: 9678059Abstract: The present invention provides a method for detecting and grading benign and malignant tumors using at least one sensor of conductive nanoparticles capped with an organic coating in conjunction with a learning and pattern recognition algorithm. The method utilizes a plurality of response induced parameters to obtain improved sensitivity and selectivity for diagnosis, prognosis, monitoring and staging various types of cancers, or for identifying or grading benign or malignant tumors.Type: GrantFiled: May 22, 2011Date of Patent: June 13, 2017Assignee: Technion Research & Development Foundation Ltd.Inventors: Hossam Haick, Gregory Shuster
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Patent number: 9664687Abstract: The present invention provides methods, compositions, and kits for the detection of neurodegenerative disease specific autoantibodies for the diagnosis of neurodegenerative diseases and risk for developing neurodegenerative diseases, and for the generation of patient-specific neurodegenerative disease diagnostic autoantibody profiles.Type: GrantFiled: April 1, 2011Date of Patent: May 30, 2017Assignee: Rowan UniversityInventor: Robert G. Nagele
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Patent number: 9476882Abstract: The invention provides assays, methods, systems, compositions, and kits for diagnosing and treating cancer.Type: GrantFiled: December 31, 2012Date of Patent: October 25, 2016Assignee: The Brigham and Women's Hospital, Inc.Inventors: Jonathan A. Fletcher, Cheng-Han Lee
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Patent number: 9375512Abstract: This invention relates to a tissue expander for use in medical, veterinary and dental applications. The tissue expander comprises a self-inflating polymer network and a biodegradable polymer having a non-degraded state and a degraded state which in the non-degraded state constrains the inflation of the self-inflating polymer network and in the degraded state allows inflation of the self-inflating polymer network. In a preferred embodiment, the self-inflating polymer network and the biodegradable polymer form an interpenetrating polymer network or a semi-interpenetrating polymer network. Alternatively or in addition, the self-inflating polymer network forms a core and the biodegradable polymer forms coating which partially or fully surrounds the core.Type: GrantFiled: November 1, 2010Date of Patent: June 28, 2016Assignee: ISIS INNOVATION LTD.Inventors: David Bucknall, Jan Czernuszk, Jinhyun Lee, Zamri Radzi, Marc Swan
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Patent number: 9101902Abstract: A method of preparing a protein chip by gelation of a sol composition. In the method, a mixture of specific silicate monomers, such as SolB1, SolB2 and SolB3, SolBH, and a mixture of SolBS, distilled water and a detector protein are mixed sequentially, so that the gelation rate of the sol composition can be delayed, thus inducing the stable gelation of the composition. Also, the biochip can be fabricated in a simple and easy manner by dispensing the sol composition by hand using an arrayer or a tool such as a pipette. In addition, a uniform biochip can be prepared by dispensing the sol composition, solution I (SolBH) and solution II (a mixture of buffer, SolBS, distilled water and a detector protein) sequentially onto a substrate without needing a conventional pretreatment process such as mixing.Type: GrantFiled: April 28, 2011Date of Patent: August 11, 2015Assignee: PCL, Inc.Inventors: Minjoung Jo, Seram Lee
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Patent number: 9046530Abstract: The present invention provides Chlamydia proteins and fragments thereof and methods of use in diagnostic assays.Type: GrantFiled: November 30, 2012Date of Patent: June 2, 2015Assignee: Board of Regents, The University of Texas SystemInventor: Guangming Zhong
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Patent number: 9040463Abstract: The invention provides a multiplexed assay device comprising a reaction chamber and several sets of encoded microcarriers 2 wherein the reaction chamber is a microchannel 1 and wherein the longitudinal movement of the microcarriers 2 is restricted and wherein the microcarriers 2 have a shape in relation to the geometry of the microchannel 1 such that at least two can stand side by side in the microchannel 1 without touching each other and without touching the perimeter of the microchannel 1 and are preferably observable in the reaction chamber. Moreover, the invention provides a method for performing multiplexed assay based on microcarriers 2 that improves mass transfer, simplifies the preparation and the execution of the assay and facilitates readout of biological reactions and identity of microcarriers 2.Type: GrantFiled: December 23, 2009Date of Patent: May 26, 2015Assignee: MYCARTIS NVInventors: Nicolas Demierre, Nader Donzel, Jose Gil, Philippe Renaud
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Patent number: 8951939Abstract: System, including methods and apparatus, for performing a digital assay with multiplexed detection of two or more distinct targets in the same optical channel.Type: GrantFiled: July 12, 2012Date of Patent: February 10, 2015Assignee: Bio-Rad Laboratories, Inc.Inventors: Serge Saxonov, Simant Dube, John Frederick Regan
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Patent number: 8859468Abstract: Pap smears and HPV infection tests do not distinguish between lesions that will progress to an invasive carcinoma and those that will not. We aimed to identify epigenetic biomarkers for diagnosis and progression monitoring of premalignant lesions in cervical cancer. Hypermethylated genes were identified as potential biomarkers after validation by MSP, including GGTLA4 and ZNF516. The methylation frequency for these two genes was higher in tumor: GGTLA4 (100%) and ZNF516 (96%); than in normal samples: GGTLA4 (12%) and ZNF516 (16%). The methylation status of GGTLA4 showed a progression in methylation frequency from normal samples to invasive carcinoma. The immunohistochemical expression was lower in tumor for both: GGTLA4 (50.8%) and ZNF516 (66.2%); than in normal samples: GGTLA4 (71.2%) and ZNF516 (88.1%) (p<0.05). In conclusion, we identified methylation biomarkers for the molecular screening and characterization of cervical cancer.Type: GrantFiled: March 11, 2011Date of Patent: October 14, 2014Assignee: The Johns Hopkins UniversityInventors: Rafael Enrique Guerrero-Preston, David Sidransky, Priscilla Brebi-Mieville
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Patent number: 8815778Abstract: The present disclosure relates to detecting receptor-ligand binding by measuring local pH modulation using a pH-sensitive fluorophore.Type: GrantFiled: December 18, 2009Date of Patent: August 26, 2014Assignee: The Texas A&M University SystemInventors: Hyunsook Jung, Aaron D Robison, Paul S. Cremer
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Patent number: 8809239Abstract: The present invention relates to the detection of a target nucleic acid sequence by a PTOCE (PTO Cleavage and Extension) assay. The present invention detects a target nucleic acid sequence in which the PTO (Probing and Tagging Oligonucleotide) hybridized with the target nucleic acid sequence is cleaved to release a fragment and the fragment is hybridized with the CTO (Capturing and Templating Oligonucleotide) to form an extended duplex, followed by detecting the presence of the extended duplex. The extended duplex provides signals (generation, increase, extinguishment or decrease of signals) from labels indicating the presence of the extended duplex and has adjustable Tm value, which are well adoptable for detection of the presence of the target nucleic acid sequence.Type: GrantFiled: January 11, 2012Date of Patent: August 19, 2014Assignee: Seegene, Inc.Inventors: Jong Yoon Chun, Young Jo Lee
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Patent number: 8647884Abstract: Multi-layered optical sensor films are disclosed. The sensor films include a first reflective layer, a detection layer over the reflective layer, and optionally a second reflective layer over the detection layer. The detection layer contains a hydrophobic, amorphous, substantially microporous, analyte-sensitive organosilicate composition. The analyte-sensitive organosilicate composition provides an optical change in the film upon analyte exposure.Type: GrantFiled: December 14, 2009Date of Patent: February 11, 2014Assignee: 3M Innovative Properties CompanyInventors: J. Christopher Thomas, Neal A. Rakow, John E. Trend
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Patent number: 8617881Abstract: Methods for producing recombinant cell populations are disclosed. The disclosed methods may be used to produce therapeutic polyclonal proteins.Type: GrantFiled: June 13, 2012Date of Patent: December 31, 2013Assignee: Excelimmune, Inc.Inventors: Vincent W. Coljee, Gwendolyn M. Wilmes, Stuart Hicks, Kimberly L. Carey, Elizabeth R. Reczek
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Patent number: 8575069Abstract: Peptides against neuropeptide Y (NPY), a biomarker associated with human performance and cognition, and methods of using the peptides to detect NPY.Type: GrantFiled: January 15, 2013Date of Patent: November 5, 2013Assignee: The United States of America as represented by the Secretary of the Air ForceInventors: Oksana M. Pavlyuk, Madhavi Kadakia, Joshua Hagen, Rajesh Naik