Abstract: A DNA encoding a 16 kD protein capable of inducing an immune response protective against human malarial infection caused by Plasmodium falciparum, and to the cloning and expression of a gene encoding the said protein. The invention further relates to novel vaccines comprising the said protein and to their use in the vaccination of humans at risk from malaria.
Type:
Grant
Filed:
May 25, 1995
Date of Patent:
August 25, 1998
Assignee:
University of Nijmegan
Inventors:
Johannes Geradus Ghislain Schoenmakers, Rudolph Nicolaas Hendrik Konings, Inge Irma Maria Dominique Moelans
Abstract: The invention is directed to transgenic plants expressing colonization and/or virulence antigens specified by genes from pathogenic microorganisms. It is also directed to the use of such transgenic plants for oral immunization of humans and other animals to elicit a secretory immune response which inhibits colonization of or invasion by such pathogenic microorganisms through a mucosal surface of humans or other animals.
Abstract: A vaccine against Lyme disease, wherein it contains one or more monoclonal antibodies which are specific for the 31 kD antigen (OspA) or the 34 kD antigen (OspB) of Borrelia burgdorferi. The present invention also provides a process for obtaining this vaccine, as well as new monoclonal antibodies and antigens.
Type:
Grant
Filed:
March 20, 1995
Date of Patent:
November 11, 1997
Assignees:
Max-Planck-Gesellschaft zur Forderung der Wissenscaften E.V., Deutsches Krebsforschun Zentrum Stiftung des Offentlichen Rechts
Inventors:
Markus M. Simon, Ulrich E. Schaible, Klaus Eichmann, Michael Kramer, Wallich Reinhard
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