Abstract: A method of treating an individual to increase the individual's bone mineral density (BMD) is disclosed. The method includes co-administering a calcitonin-like agent and a DHEA-like agent. Also disclosed are methods for potentiating the effect of treatment with a calcitonin-like agent on BMD and for increasing BMD in an individual being treated with DHEA, e.g., for treatment of systemic lupus erythematosus (SLE).

Abstract: A replacement heart valve is configured to replace a native atrioventricular heart valve (mitral or tricuspid valve, positioned between an atrial chamber and a ventricular chamber). The replacement valve includes a a thin and flexible wall portion having no more than two leaflets. Two securement locations adjacent the outlet end of the valve are adapted to be attached to respective papillary muscles. The unconstrained regions between the securement locations flex inwardly into and out of engagement with each other in response to blood pressure in order to close and open the valve. The leaflets engage each other along a line of commissure.

Abstract: A prosthetic lock assembly of the ratchet type for connecting a liner for a prosthetic socket to a prosthesis. The lock assembly includes a two part locking mechanism held together by suitable fasteners. Removal or loosening of the fasteners enables a user to separate the two parts from one another in the event a sock gets into and jams the locking mechanism. In a first set of four embodiments, a latch is formed in a first part of the locking mechanism and in a second set of four embodiments, the latch is formed in a second part of the locking mechanism. The lock assembly may be mounted internally or externally of the prosthetic socket. The first part of the locking mechanism may be a laminating ring or a thermoforming plate and the second part may be a mounting block with or without a pyramid for controlling a prosthetic pylon.