Patents Examined by Wu-Cheng Winston Shen
  • Patent number: 8962629
    Abstract: The invention provides a compound of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
    Type: Grant
    Filed: June 9, 2009
    Date of Patent: February 24, 2015
    Assignee: AbbVie Inc.
    Inventors: Neil Wishart, Maria A. Argiriadi, David J. Calderwood, Anna M. Ericsson, Bryan A. Fiamengo, Kristine E. Frank, Michael M. Friedman, Dawn M. George, Eric R. Goedken, Nathan S. Josephsohn, Biqin C. Li, Kent D. Stewart, Grier A. Wallace, Lu Wang, Kevin R. Woller
  • Patent number: 8957057
    Abstract: The present invention concerns the uses of an azaphilone compound of formula (I): formula (I): or a pharmaceutically acceptable derivative thereof as described in the specification for modulation of the activity of a nuclear hormone receptor and for prevention and/or treatment of a disease or disorder related to nuclear hormone receptor activity.
    Type: Grant
    Filed: April 5, 2010
    Date of Patent: February 17, 2015
    Assignee: Food Industry Research and Development Institute
    Inventors: Ta-Wei D. Liu, Yen-Lin Chen, Ming-Der Wu, Ming-Jen Cheng, Hui-Ping Chen, Wen-Jung Wu, Kai-Ping Chen, Yu-Shan Lin, Gwo-Fang Yuan
  • Patent number: 8957113
    Abstract: Disclosed are immediate release oral tranexamic acid formulations and methods of treatment therewith.
    Type: Grant
    Filed: January 28, 2011
    Date of Patent: February 17, 2015
    Assignee: Ferring B.V.
    Inventors: Keith A. Moore, Ralph A. Heasley, Jeffrey S. Greiwe, John W. Facemire, Jason D. Modest
  • Patent number: 8952065
    Abstract: This invention relates to novel acetylcysteine compositions in solution, comprising acetylcysteine and which are substantially free of metal chelating agents, such as EDTA. Further, this invention relates to methods of making and using the acetylcysteine compositions. The present compositions and methods are designed to improve patient tolerance and compliance, while at the same time maintaining the stability of the pharmaceutical formulation. The compositions and methods of this invention are useful in the treatment of acetaminophen overdose, acute liver failure, various cancers, methacrylonitrile poisoning, reperfusion injury during cardio bypass surgery, and radiocontrast-induced nephropathy, and can also be used as a mucolytic agent.
    Type: Grant
    Filed: January 13, 2014
    Date of Patent: February 10, 2015
    Assignee: Cumberland Pharmaceuticals, Inc.
    Inventor: Leo Pavliv
  • Patent number: 8952070
    Abstract: There is provided a pharmaceutical composition for the treatment of fungal infection of the nail comprising a anti-fungal allylamine compound present in an amount of about 10%, an organic acid or an ester thereof, a diol and a sequestering agent where the pharmacological composition is essentially water-free.
    Type: Grant
    Filed: February 10, 2012
    Date of Patent: February 10, 2015
    Assignee: Moberg Pharma AB
    Inventor: Ake Lindahl
  • Patent number: 8946234
    Abstract: The invention relates to compounds of the general formula (I), in which the radicals A1, A2, A3, A4, Lm, Q, R1, T and U have the meaning given in the description and to the use of the compounds for controlling animal pests. In addition, the invention relates to processes and intermediates for the preparation of the compounds according to formula (I).
    Type: Grant
    Filed: October 27, 2009
    Date of Patent: February 3, 2015
    Assignee: Bayer CropScience AG
    Inventors: Michael Maue, Isabelle Adelt, Wolfgang Giencke, Markus Heil, Peter Jeschke, Bernd-Wieland Krüger, Friedrich August Mühlthau, Alexander Sudau, Klaus Raming, Ulrich Ebbinghaus-Kintscher, Martin Adamczewski, Arnd Voerste, Ulrich Görgens, Tobias Kapferer, Mark Wilhelm Drewes, Angela Becker, Eva-Maria Franken
  • Patent number: 8946267
    Abstract: A therapeutic agent or a prophylactic agent for neuropathic pain provides a synergistically-enhanced analgesic effect at a dose at which a calcium channel ?2? ligand does not produce any side effects as well as which agent does not produce any new side effects on the central nervous system. The therapeutic agent or a prophylactic agent for neuropathic pain includes as effective ingredients a cyclohexane derivative, represented by the following formula, or a pharmaceutically acceptable salt thereof or a prodrug thereof, and a calcium channel ?2? ligand.
    Type: Grant
    Filed: July 29, 2011
    Date of Patent: February 3, 2015
    Assignee: Toray Industries, Inc.
    Inventors: Naoki Izumimoto, Hidenori Mochizuki
  • Patent number: 8940721
    Abstract: Compositions and methods for treating macular degeneration and other forms of retinal disease whose etiology involves the accumulation of A2E and/or lipofuscin, and, more specifically, for preventing the formation and/or accumulation of A2E are disclosed.
    Type: Grant
    Filed: July 1, 2011
    Date of Patent: January 27, 2015
    Assignee: Aldexa Therapeutics, Inc.
    Inventors: Thomas A. Jordan, John E. Dowling, John Clifford Chabala
  • Patent number: 8940737
    Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.
    Type: Grant
    Filed: October 11, 2012
    Date of Patent: January 27, 2015
    Assignee: AbbVie Inc.
    Inventors: Le Wang, George Doherty, Xilu Wang, Zhi-Fu Tao, Milan Bruncko, Aaron R. Kunzer, Michael D. Wendt, Xiaohong Song, Robin Frey, Todd M. Hansen, Gerard M. Sullivan, Andrew Judd, Andrew Souers
  • Patent number: 8937062
    Abstract: Compositions comprise a fluoroquinolone having Formulae I-VIII for treating, reducing, ameliorating, or preventing infections caused by some bacteria that are resistant to an antibacterial drug. Methods for treating, reducing, ameliorating, or preventing such infections use such compositions.
    Type: Grant
    Filed: March 19, 2008
    Date of Patent: January 20, 2015
    Assignee: Bausch & Lomb Incorporated
    Inventors: Praveen Tyle, Pramod Kumar Gupta, Susan E. Norton, Lynne Brunner, Joseph Blondeau
  • Patent number: 8933037
    Abstract: The invention refers to PDGFRbeta inhibitor for use in the antiproliferative treatment of T-cell lymphoma, in particular NHL, ALCL and PTCL.
    Type: Grant
    Filed: September 28, 2010
    Date of Patent: January 13, 2015
    Assignee: Medizinische Universitat Wien
    Inventors: Lukas Kenner, Daniela Laimer
  • Patent number: 8933069
    Abstract: Provided is a compound useful for the prophylaxis or treatment of cancer. The present invention relates to a compound represented by formula (I): wherein each symbol in the formula is as defined in the specification, or a salt thereof or a prodrug thereof, which is useful for the prophylaxis or treatment of cancer.
    Type: Grant
    Filed: March 24, 2014
    Date of Patent: January 13, 2015
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Misaki Homma, Yuya Oguro
  • Patent number: 8921354
    Abstract: Provided is a compound useful for the prophylaxis or treatment of cancer. The present invention relates to a compound represented by formula (I): wherein each symbol in the formula is as defined in the specification, or a salt thereof or a prodrug thereof, which is useful for the prophylaxis or treatment of cancer.
    Type: Grant
    Filed: March 24, 2014
    Date of Patent: December 30, 2014
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Misaki Homma, Toru Miyazaki
  • Patent number: 8921350
    Abstract: Compounds and methods are provided for the treatment of, inter alia, Type II diabetes and other diseases associated with poor glycemic control. The compounds of the invention are orally active.
    Type: Grant
    Filed: January 16, 2013
    Date of Patent: December 30, 2014
    Assignee: CymaBay Therapeutics, Inc.
    Inventors: Xin Chen, Peng Cheng, L. Edward Clemens, Jeffrey D. Johnson, Jingyuan Ma, Alison Murphy, Imad Nashashibi, Christopher J. Rabbat, Jiangao Song, Maria E. Wilson, Yan Zhu, Zuchun Zhao
  • Patent number: 8921428
    Abstract: There is provided a pharmaceutical composition for the treatment of fungal infection of the nail comprising a anti-fungal allylamine compound present in an amount of about 10%, an organic acid or an ester thereof, a diol and a sequestering agent where the pharmacological composition is essentially water-free.
    Type: Grant
    Filed: February 10, 2012
    Date of Patent: December 30, 2014
    Assignee: Moberg Pharma AB
    Inventor: Ake Lindahl
  • Patent number: 8916592
    Abstract: Compounds of formula I wherein X is O or S(?O)n; n is 0, 1 or 2; R1 is optionally substituted alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, cycloalkyl, halocycloalkyl, cycloalkenyl, halocycloalkenyl, phenyl, hetaryl, phenylalkyl, hetaryl alkyl, optionally fused to phenyl, hetaryl or heterocyclyl; A is —NRb2, —C(=G)GRb, —C(=G)NRb2, —C(?NORb)Rb, C(=G)[N?SRb2], —C(=G)NRb—NRb2, C2-C6-alkandiyl, C2-C6-alkenediyl, C1-C3-alkyl-G-C1-C3-alkyl, wherein Rb is as defined in the description, or optionally substituted phenyl, hetaryl, heterocyclyl, optionally fused to phenyl or heterocyclyl; B is an optionally substituted saturated or partially unsaturated hydrocarbon chain with 1 to 3 carbon chain atoms; D is an optionally substituted saturated or partially unsaturated hydrocarbon chain with 1 to 5 carbon chain atoms or C3-C6-cycloalkyl; G is oxygen or sulfur; or the enantiomers or diastereomers or salts or N-oxides thereof, processes for preparing the compounds I, pesticidal compositions and synergistic m
    Type: Grant
    Filed: December 13, 2006
    Date of Patent: December 23, 2014
    Assignee: Merial Limited
    Inventors: Matthias Pohlman, Michael Hofmann, Henricus Maria Martinus Bastiaans, Michael Rack, Deborah L. Culbertson, Hassan Oloumi-Sadeghi, Takeo Hokama, Christopher Palmer, Jürgen Langewald
  • Patent number: 8912175
    Abstract: The invention provides a topical formulation adapted for treatment of a skin condition comprising (i) at least one retinoid; and (ii) salicylic acid or an ester, amide, salt, or solvate thereof. The invention also includes a kit for treatment of skin conditions comprising a retinoid and salicylic acid, as well as a method of treating skin conditions utilizing the inventive formulation and kit.
    Type: Grant
    Filed: September 18, 2014
    Date of Patent: December 16, 2014
    Assignee: Molecular Design International, Inc.
    Inventor: William P. Purcell
  • Patent number: 8912173
    Abstract: Disclosed are substituted quinolines of formula 1 wherein R1 and R2 are defined herein, the processing of making and using the same.
    Type: Grant
    Filed: July 20, 2012
    Date of Patent: December 16, 2014
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Matthias Hoffmann, Daniel Bischoff, Georg Dahmann, Jasna Klicic, Gerhard Schaenzle, Stefan Ludwig Michael Wollin, Serge Gaston Convers-Reignier, Stephen Peter East, Frederic Jacques Marlin, Clive McCarthy, John Scott
  • Patent number: 8906928
    Abstract: The present invention relates to substituted pyrazolo-pyrrolo-pyridine-dione compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted pyrazolo-pyrrolo-pyridine-dione compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds or pharmaceutical compositions to subjects in need thereof.
    Type: Grant
    Filed: March 31, 2010
    Date of Patent: December 9, 2014
    Assignee: ArQule, Inc.
    Inventors: Jason Hill, Manish Tandon, Nivedita Namdev, Rocio Palma, Neil Westlund, Anton Filikov
  • Patent number: 8901177
    Abstract: The present invention relates to dexmecamylamine and the use of dexmecamylamine, substantially free of exo-R-mecamylamine, in the treatment of bladder disorders, including overactive bladder.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: December 2, 2014
    Assignee: Targacept, Inc.
    Inventors: Merouane Bencherif, Steven M. Toler