Abstract: A stemless humeral anchor (10) includes a first end (12) configured to be embedded in a proximal portion of a humerus and a second end (14); a mating portion (16) for an articular component; a transversely extending collar (20); and a rotation control feature (22, 22A) for resisting rotation when the stemless humeral anchor is implanted. A void filling protrusion (24) can extend circumferentially from rotation control feature and can include a porous shell (26), in which a void filling component (28) can be disposed. The rotation control feature can comprise arms. One or more arms (22A) can have a larger radial extent than the others (22). A prosthesis assembly includes a base member (104) that has a helical structure (224) and one or more pathways (300). The pathway is accessible from a proximal end and is directed distally through the helical structure. The pathway is located inward of an outer periphery of the helical structure.

Abstract: A system and method for an improved connective tissue repair option that reduces disadvantages of conventional fixation options. Biologic press fit fixation of a connective tissue unit may include in situ expansion of a pre-compressed connective tissue unit within a prepared bone tunnel of a portion of bone. An external opening accessing a cavity of the prepared bone tunnel may be smaller than that of the cavity such that expansion of the installed/compressed connective tissue unit increases lateral fixation forces exerted by the expanding/decompressing compressed connective tissue unit within the bone tunnel.

Abstract: The present invention provides an artificial blood vessel that can achieve a balance between cell penetration efficiency and crush resistance and can regenerate a blood vessel at very high efficiency. Provided is an artificial blood vessel having a tubular shape, including: a foam containing a bioabsorbable material; a reinforcement A containing a bioabsorbable material; and a reinforcement B including threads containing a bioabsorbable material, the foam being reinforced with the reinforcements A and B, wherein the reinforcement A is a non-woven fabric, a film, or a weft-knitted, warp-knitted, or woven fabric made of knitted or woven fibers, the reinforcement B includes monofilament threads each having a cross-sectional diameter of 0.

Abstract: This document describes systems and method of embedded printing for additive manufacturing. A print material is printed into a support material. The print material and the support material each have a fluid phase and a solid phase. The print material transitions from the fluid phase to the solid phase based on a fluid-fluid interaction with the support material. One or more parameters of the support material can be adjusted to cause a diffusion rate of the print material into the support material during the fluid-fluid interaction to be less than a threshold value. Multiple print materials can be printed into the support material simultaneously.

Abstract: A bone repair composition and methods thereof include bone fibers made from cortical bone in which a plurality of bone fibers are made into various implant shapes conducive to introduction into a patient through minimally invasive surgery. The bone fiber compositions may be in the form of a pellet or cylinder. A method includes producing the bone fiber graft efficiently with control of key parameters of cohesiveness, rehydration and swelling of the bone fiber graft. Another method includes introducing the bone fiber graft into the cannula efficiently. A method is also provided to allow introduction of a bone graft into a patient by placing the implant in a tube and expelling it through the action of a plunger.

Abstract: Described are implants for placing in a body, tools for delivering the implants, and systems and methods for using implants and tools for placing in a body and more particularly to nasal implants, tools for delivering nasal implants, and systems and methods for using such implants and tools. A tool may include a hand-held implant delivery device that cuts, holds, moves, orients, inserts, or shapes an implant. An implant may be a biodegradable, longitudinal implant that may be oriented for implantation by an implant delivery device.

Abstract: Systems and methods employ bioresorbable corneal implants to treat corneal ectatic disorders and/or refractive errors. The corneal implants may be formed from a porous microstructure that can encourage the proliferation of endogenous keratocytes. As such, the corneal implants act as tissue scaffolds that promote tissue growth to increase the biomechanical stability and/or change the shape of the cornea. Over time, the corneal implants may resorb via hydrolysis or enzymatic breakdown, negating the risks of inflammation, scarring, or foreign body response. The corneal implants may also employ drug coating(s) to promote tissue growth.

Abstract: A fixation apparatus is provided that includes a reception portion on a proximal end of the fixation apparatus. The reception portion couples the fixation apparatus to a tension element, and adjustment of the tension element with respect to the fixation apparatus does not cause a change in a position of the fixation apparatus. The fixation apparatus also includes a chamber in a distal portion of the fixation device. The chamber provides a supportive enclosure for a tension element that runs through the chamber and is anchored at the reception portion, and a force vector of the tension element exiting at the distal end of the fixation device is redirected at an axis independent of the axis of the fixation apparatus from the proximal end to the distal end.

Abstract: Provided herein are ligament docking implants and methods for making and using the same. In at least one embodiment, the implants include at least one docking recess configured to receive a tissue structure such as a ligament and connect said tissue to the implant via suitable surgical techniques. In at least one embodiment, the docking recesses of the implant include a gyroid architecture that provides for improved mechanical performance and tissue integration. In various embodiments, the present methods of using the ligament docking implants include the use of sutures to connect tissue to the implant via the docking recess.

Abstract: A resorbable bone graft scaffold material, including a plurality of overlapping and interlocking fibers defining a scaffold structure, plurality of pores distributed throughout the scaffold, and a plurality of glass microspheres distributed throughout the pores. The fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers, and the fibers are a bioactive, resorbable material. The fibers generally contribute about 20 to about 40 weight percent of the scaffold material, with the microspheres contributing the balance.

Abstract: The present invention relates to an implantable pouch which contains a rigid plate in its inner volume, thereby preventing said pouch to be folded.

Abstract: A graft fixation device comprising: a graft separator comprising a distal end, a proximal end, a cavity disposed between the distal end and the proximal end, and at least one guide rib disposed radially outboard of the cavity and extending between the distal end and the proximal end; and an interference screw rotatably mountable within the cavity, the interference screw comprising a distal end, a proximal end, and a screw thread disposed intermediate thereof, the screw thread disposed radially outboard of at least a portion of the graft separator and radially inboard of the at least one rib.

Abstract: Breast fixation devices for use in breast reconstruction and breast augmentation limit the rotation or movement of breast implants after implantation that results in an unnatural appearance of the breast. The breast fixation devices can include a thin-walled enclosure in the shape of a pouch. A breast implant is secured inside the pouch to limit movement by applying compression to the breast implants, or using a mating or interlocking mechanism between the pouch and breast implant. The pouches containing the breast implants are implanted in the breast. Tissue in-growth into the pouch limits movement of the pouch-breast implant assembly and thereby limits rotation, migration, and displacement of the breast implant. The pouches preferably comprise poly-4-hydroxybutyrate or copolymer thereof.

Abstract: A prosthesis for attachment to an external surface of a trachea and support a membranous portion of the trachea is disclosed. The prosthesis includes a first member, a second member and a biasing member engaged with the first member and the second member. The first member has at least one first tooth adapted to be inserted inside the membranous portion. The second member is movably coupled to the first member and includes at least one second tooth disposed substantially opposite to the at least one first tooth. The at least second tooth is configured to be inserted inside the membranous portion. The biasing member biases the first member relative to the second member to a first position. The first member and the second member are disposed away from the first position when engaged with the trachea applying a tension force on the membranous portion.

Abstract: In one aspect, an implant for replacing subject tissue includes a nonbiologic portion and a biologic portion grown on the nonbiologic portion. The biologic portion may be grown on the nonbiologic portion before being implanted in the subject. The nonbiologic portion may comprise a porous metal substrate (e.g., scaffolding). The nonbiologic portion may be formed by 3D printing (i.e., additive manufacturing). The nonbiologic portion may be patient-specific. A robot may be used to shape the implant before implantation and/or to shape bone being replaced/resurfaced.

Abstract: Delivery devices and vascular devices are described for addressing a target site within a body lumen. The delivery device includes one or more ultrasound transducers positioned to transmit and receive ultrasound signals so as to provide an image of an interior of the patient's blood vessel within which the vascular device is disposed in real time, as the procedure is taking place. Using the images provided by the ultrasound transducers, the longitudinal and rotational position of the delivery device (and the vascular device constrained therein) may be adjusted to align the vascular device with the patient's vasculature. In some examples, the vascular device being delivered includes fenestrations, whereas in others the vascular device integral branch grafts.

Abstract: An implantable acellular polymeric scaffold device functionalized with aggrecan is provided. Also provided are methods of fabricating a polymeric scaffold device, including methods of fabricating the scaffold device via 3D printing. Methods of treating a cartilage defect in a subject in need thereof comprise application of the disclosed scaffold device in combination with microfracture procedures. A specialized lid for a centrifugation well plate is also provided.

Abstract: A medical device comprising a device that covers at least a portion of a patient's skin and has an inner surface designed to be in contact with the patient's skin. It contains a multi-ply knit fabric that contains a first knit ply and a second knit ply. The first knit ply contains a plurality of first yarns and forms the upper surface of the fabric. The second knit ply contains a plurality of polytetrafluoroethylene (PTFE) yarns which forms the lower surface of the fabric. The first and second ply are integrated through combined portions formed by interlacing first yarns among the PTFE yarns, interlacing PTFE yarns among the first yarns, and interlacing a plurality of third yarns among the first and the PTFE yarns. The multi-ply knit fabric also contains a composition comprising at least one silver ion-containing compound on at least the upper surface of the multi-ply knit fabric.

Abstract: A composite scaffold having a highly porous interior with increased surface area and void volume is surrounded by a flexible support structure that substantially maintains its three-dimensional shape under tension and provides mechanical reinforcement during repair or reconstruction of soft tissue while simultaneously facilitating regeneration of functional tissue.

Abstract: A prosthetic heart valve includes a stent extending in a longitudinal direction and having a collapsed condition and an expanded condition. The stent includes a plurality of struts forming cells and a plurality of commissure attachment features spaced apart in an annular direction of the stent and extending in a medial direction of the stent. A valve assembly is secured to the commissure attachment features, the valve assembly including a cuff and a plurality of leaflets, each of the leaflets having a free edge and being capable of alternating between an open position and a closed position. A method of manufacturing the prosthetic heart valve is also provided.