Abstract: The present discussion relates to structures and devices to facilitate application of an ultrasound therapy beam to a target anatomic region in a replicable manner. In certain aspects, adjustable positioning structures are described that allow a general probe positioning structure to be configured for a specific patient in a manner that allows the device to be used repeatedly to target the anatomic region, even when in non-clinical settings. In other aspects, a probe positioning structure is fabricated that is specific to a respective patient anatomy, such that use of the probe positioning structure provides repeatable targeting of the target anatomic region, even when in non-clinical settings.

Abstract: A system and method to compensate for transit-induced vibration when detecting heart rate using radar sensors is provided. Embodiments provide a radio frequency RF sensor for heart rate detection when a subject is in transit (e.g., in a vehicle and/or subject to human-induced motion), where the RF sensor is designed to cancel vibration noise while preserving a cardiac signal in a radar response so that a heart rate, respiratory rate, and related physiological parameters of a subject under test can be extracted. In some examples, a heart rate variability (HRV) and/or state of the subject under test can be derived from these physiological parameters as well. The RF sensor with vibration cancellation can be installed in multiple locations in a vehicle, including a car seat, a steering wheel, a roof of the vehicle, a visor, or a rearview mirror; alternatively, the components may be held or worn by a subject, or arranged proximate to a subject.

Abstract: The systems and methods can accurately and efficiently determine boundary conditions for an arterial segment and thereby efficiently determine hemodynamic information for that segment. The method may include receiving medical image data of a patient. The method may further include generating a geometrical representation of the one or more arterial segments from the medical image data. The method may further include determining boundaries and geometry data for each arterial segment. The method may further include determining boundary conditions for the inflow boundary and each outflow boundary. The boundary conditions for each outflow boundary may be determined using an outflow distribution parameter. The outflow distribution parameter may be determined using the geometry data for one or more of the one or more outflow boundaries, stored hemodynamic data, or a combination thereof. The method may further include determining flow field for each arterial segment and determining hemodynamic information.

Abstract: Provided are a portable electronic device, an accessory, and an operation method thereof. The portable electronic device includes a light source irradiating light to skin, at least one light detector detecting light received from the skin, at least one memory storing an instruction, and a processor, by executing the instruction, controlling the light source to irradiate the light and analyzing a skin state based on light detected by the light detector.

Abstract: The methods and systems described herein enable the accurate diagnosis of novel biotypes of depression that transcend current diagnostic boundaries and may be useful for identifying individuals who are most likely to benefit from antidepressant treatment. Functional magnetic resonance imaging is used to characterize the architecture of functional connectivity across the brain to show that patients with depression can be subdivided into four neurophysiological biotypes based solely on unique patterns of abnormal connectivity in resting state brain networks. Clustering subjects on this basis reduces diagnostic heterogeneity, enabling the development of depression biotype classifiers for diagnosing biotypes of depresion in individual patients, These biotypes also predict differing responses to antidepressant treatment, and abnormal connectivity patterns can be used to track changes in depression severity over time.

Abstract: A method for imaging may include directing a PET scanner to perform scans of a subject injected with a tracer during a first time period. The method may also include generating PET images by reconstructing the PET data that are generated by the PET scanner based on the scans of the subject. The method may also include determining a first portion of a blood input function of the tracer in the subject based on the PET images. The method may also include determining an integral of a second portion of the blood input function based on a kinetic model, the PET data, and the first portion of the blood input function. The method may also include determining kinetic parameters of the kinetic model based on the PET data, the first portion of the blood input function, and the integral of the second portion of the blood input function.

Abstract: An ultrasound probe (10) is disclosed comprising a plurality of transducer elements (66) within a housing (60) and arranged proximal to a subject contact surface (65) of the probe; a plurality of individually addressable light sources (72) mounted in said housing, each of said individually addressable light sources indicating a position of a subset of the plurality of transducer elements relative to said subject contact surface; and a controller (80) arranged to control said plurality of individually addressable light sources in response to a light source selection signal from an ultrasound user console (3). Also disclosed is such an ultrasound user console (3), an ultrasound imaging system (1) comprising the ultrasound probe (10) and the ultrasound user console (3) as well as a method (100) of marking the location of an anatomical feature (7) within a subject with such an ultrasound imaging system (1).

Abstract: An ultrasound endoscope includes: a distal end portion that is provided on a distal end of an insertion portion; a curvature portion that is connected to a proximal end side of the distal end portion in the insertion portion; a plurality of coaxial wires that are inserted into the curvature portion; a convex ultrasound transducer provided in the distal end portion; and a relay substrate that is disposed in the distal end portion, is connected to the ultrasound transducer, and is connected to the coaxial wires. The relay substrate includes a first surface that is connected to the ultrasound transducer, a second surface that is connected to the coaxial wires, and a third surface that is continuous to the first surface through a first flexure portion and is continuous to the second surface through a second flexure portion.

Abstract: An optical shape sensing system includes an attachment mechanism (130) being configured to secure an optical shape sensing fiber to an instrument, the optical shape sensing fiber being connected to the instrument and configured to identify a position and orientation of the instrument. An optical shape sensing module (115) is configured to receive feedback from the optical shape sensing fiber and register the position of the instrument relative to an operating environment. A position response module (144) is configured to provide feedback to an operator based on position or orientation of the instrument to guide usage of the instrument.

Abstract: Systems and methods for monitoring and controlling delivery of a therapeutic compound to a brain of a subject using FUS-BBBD are disclosed. The method includes treating the brain of the subject with focused ultrasound in combination with microbubbles for blood-brain barrier disruption (FUS-BBBD), administering the therapeutic agent to the subject; and obtaining a map of a concentration of the therapeutic agent delivered to the brain of the subject using passive cavitation imaging (PCI). The delivery of focused sound may be modulated to match the map of the concentration of the therapeutic agent delivered to the brain of the subject to a desired spatial distribution of the therapeutic agent.

Abstract: The present disclosure relates to an apparatus for mounting on a guide member for insertion into an anatomical cavity, the apparatus comprising a body defining a cavity for receiving a guide member therethrough, a drive arrangement for moving the body along a guide member disposed through the body, a probe secured to the body for, in use, obtaining a measurement from, taking a sample of, applying a substance to, or applying a therapy to, an environment of the body, and a measurement arrangement for measuring a position relative to the guide member disposed through the body.

Abstract: An ultrasound diagnosis apparatus includes: a display displaying a body marker including a first type of first probe marker related to a first ultrasound image of an object; an image processor configured to obtain a second ultrasound image of the object; and a controller configured to identify a position of a probe used to obtain the second ultrasound image in the body marker and mark a second type of second probe marker on the body marker according to a result of comparing a position of the first type of first probe marker with the identified position, wherein the second type is different from the first type.

Abstract: An implantable ultrasound generating treating device (12) to induce spinal cord or spinal nerves treatment, suitable for implantation in the spinal canal and comprises an elongate support member (22, 32) and an array of several treatment transducers (20) distributed along the elongate support member. The several treatment transducers (20) comprise radial transducers emitting an ultrasound treatment beam oriented radially, wherein the treatment transducers (20) have a resonant frequency comprised between 0.5 and 4 MHz. The device has articulating portions so that the implantable device can adapt its shape to a curved elongation path. Also disclosed is an apparatus including the implantable ultrasound generating treating device and methods comprising inserting the implantable ultrasound generating treating device (12) inside the spinal canal of the spine of the patient.

Abstract: A system and method for planning surgical procedure including a treatment zone setting view presenting at least one slice of a 3D reconstruction generated from CT image data including a target. The treatment zone setting view presenting a treatment zone marker defining a location and a size of a treatment zone and configured to adjust the treatment zone marker in response to a received user input. The system and method further including a volumetric view presenting a 3D volume derived from the 3D reconstruction and a 3D representation of the treatment zone marker relative to structures depicted in the 3D volume.

Abstract: Systems and methods of facilitating the viewing of interventional instruments (e.g., needles, catheters, guidewires, vascular filters, biopsy probes) are disclosed herein. In one embodiment, a portable, handheld or cart-based ultrasound imaging machine is connected to an external laser light source that transmits laser light to a tip of an interventional instrument via one or more optical fibers. The laser light is absorbed at the distal tip of the instrument and generates a photoacoustic signal. The ultrasound imaging machine creates an image by combining data from the received photoacoustic signals with ultrasound echo data to show both tissue in a region of interest and the tip of the interventional instrument.

Abstract: Provided herein are an apparatus, system, and method for a medical diagnostic and imaging forceps for determining the pathology of tissue in vivo during surgery, endoscopy, laparoscopy, or other medical procedure, the forceps comprising a platform for analyzing tissue pathology inside the body by way of sensors including without limitation conductivity, optical, tracking, and x-ray sensors.

Abstract: A method for evaluating a movement state of a heart is provided and includes: obtaining a plurality of consecutive heart ultrasound images corresponding to a heart and accordingly estimating a plurality of left ventricular volumes corresponding to the heart ultrasound images; finding a plurality of specific extremums in the left ventricular volumes and accordingly estimating a plurality of time differences among the specific extremums; estimating a statistical characteristic value of the time differences based on the time differences; and determining that an abnormal movement state of the heart occurs in response to determining that at least one of the time differences deviates from the statistical characteristic value up to a predetermined threshold.

Abstract: An ultrasound patch includes one or more transmit and receive piezoelectric transducer elements. In some embodiments, the transducer elements are positioned on a ramp on a patient pad of the patch that is configured to fit within an anatomic space between the trachea and the sternocleidomastoid muscle to orient the transducer elements toward a carotid artery. In some embodiments, a flexible phased array transducer includes a number of pillar piezoelectric elements joined by a flexible adhesive with metal electrodes deposited thereon. The phased array transducer is mounted to a flexible circuit board that allows the transducer to bend and conform to a subject's anatomy.

Abstract: A method of operating an optically pumped magnetometer (OPM) includes directing a light beam through a vapor cell of the OPM including a vapor of atoms; applying RF excitation to cause spins of the atoms to precess; measuring a frequency of the precession; for each of a plurality of different axes relative to the vapor cell, directing a light beam through the vapor cell, applying a magnetic field through the vapor cell along the axis, applying RF excitation to cause spins of the atoms to precess, and measuring a frequency of the precession in the applied magnetic field; determining magnitude and components of an ambient background magnetic field along the axes using the measured frequencies; and applying a magnetic field based on the components around the vapor cell to counteract the ambient background magnetic field to facilitate operation of the OPM in a spin exchange relaxation free (SERF) mode.

Abstract: The embodiments herein provide a system for calibration-free cuff-less evaluation of blood pressure. The system includes an ultrasound-based arterial compliance probes and a controller unit connected to the said probe. The ultrasound transducers are configured to measure the change in arterial dimensions, pulse wave velocity, and other character traits of an arterial segment over continuous cardiac cycle, which is then used to evaluate blood pressure parameters without any calibration procedure using dedicated mathematical models.