Patents Examined by Yong Chong
  • Facially amphiphilic polymers and oligomers and uses thereof
    Patent number: 9241917
    Abstract: The present invention discloses methods of use of facially amphiphilic polymers and oligomers, including pharmaceutical uses of the polymers and oligomers as antimicrobial agents and antidotes for hemorrhagic complications associated with heparin therapy. The present invention also discloses novel facially amphiphilic polymers and oligomers and their compositions, including pharmaceutical compositions. The present invention further discloses the design and synthesis of facially amphiphilic polymers and oligomers.
    Type: Grant
    Filed: March 17, 2004
    Date of Patent: January 26, 2016
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: William F. DeGrado, Gregory N. Tew, Michael L. Klein, Dahui Liu, Jing Yuan, Sungwook Choi
  • Phosphodiesesterase 4 inhibitors for the treatment of a cognitive deficit
    Patent number: 9241925
    Abstract: The present invention provides methods of treating cognitive deficits associated with mental retardation. The methods comprise combining cognitive training protocols and a general administration of phosphodiesterase 4 inhibitors.
    Type: Grant
    Filed: January 10, 2011
    Date of Patent: January 26, 2016
    Assignee: Dart NeuroScience LLC
    Inventors: Timothy P. Tully, Filippo Cavalieri, Rusiko Bourtchouladze
  • Antimicrobial compounds
    Patent number: 9241928
    Abstract: This disclosure relates to compositions including certain compounds identified by a quantitative, high throughput assay to be effective in inhibiting the ability of a bacterium to kill a host organism, as well as methods for using these compounds for treating bacterial infections.
    Type: Grant
    Filed: June 25, 2010
    Date of Patent: January 26, 2016
    Assignees: The General Hospital Corporation, Northeastern University
    Inventors: Terence Moy, Annie Conery, Kim Lewis, Frederick M. Ausubel, Read Pukkila-Worley
  • Lactam derivatives useful as orexin receptor antagonists
    Patent number: 9242970
    Abstract: The present invention relates to lactam derivatives of formula (I) wherein Y, R1, R2 and R3 are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as orexin receptor antagonists.
    Type: Grant
    Filed: November 9, 2011
    Date of Patent: January 26, 2016
    Assignee: ACTELION PHARMACEUTICALS LTD.
    Inventors: Hamed Aissaoui, Christoph Boss, Christine Brotschi, Bibia Heidmann, Thierry Sifferlen, Jodi T. Williams
  • Amide derivative, pest control agent containing the amide derivative, and use of the amide derivative
    Patent number: 9237745
    Abstract: An amide derivative represented by the following Formula (1) is provided as an amide derivative showing a significantly excellent effect for a pest control action. In the following Formula (1), A represents a carbon atom, a nitrogen atom, or the like, and K represents a non-metal atomic group necessary for forming a cyclic linking group derived from benzene or a heterocyclic. X represents a halogen atom or the like; n represents an integer of from 0 to 4. R1 and R2 represent hydrogen atoms, alkyl groups, or the like. T represents —C(=G1)-Q1 or —C(=G1)-G2Q2, and G1 to G3 each represent oxygen atoms or the like. Q1 and Q2 each represent a hydrogen atom, an alkyl group, an aryl group, or the like. Y1 and Y5 each represent a halogen atom or the like, Y2 and Y4 each represent a hydrogen atom or the like, and Y3 represents a C2-C5 haloalkyl group.
    Type: Grant
    Filed: March 18, 2013
    Date of Patent: January 19, 2016
    Assignee: Mitsui Chemicals Agro, Inc.
    Inventors: Yumi Kobayashi, Hidenori Daido, Hiroyuki Katsuta, Michikazu Nomura, Hidetaka Tsukada, Atsushi Hirabayashi, Yusuke Takahashi, Yoji Aoki, Atsuko Kawahara, Yasuaki Fukazawa, Mai Hirose
  • Lipid-lowering antidiabetic agent
    Patent number: 9216951
    Abstract: A composition which includes a salt of metformin and the use of the composition for treatment of or use in prediabetes, diabetes, lowering triglycerides and/or other conditions in mammals.
    Type: Grant
    Filed: October 27, 2014
    Date of Patent: December 22, 2015
    Assignee: Thetis Pharmaceuticals LLC
    Inventors: Banavara L. Mylari, Frank C. Sciavolino
  • Pyrazole compounds as CRTH2 antagonists
    Patent number: 9206164
    Abstract: The present invention relates to pyrazole compounds of formula (I) and pharmaceutically acceptable salts thereof having CRTH2 antagonistic activity, wherein L, Y1, Y2, Y3, Y4, Y5, Z, R1, R2, R3 and n have one of the meanings as indicated in the specification and claims, to their use as medicaments, to pharmaceutical compositions containing said compounds and to pharmaceutical compositions containing said compounds in combination with one or more active substances.
    Type: Grant
    Filed: March 15, 2012
    Date of Patent: December 8, 2015
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Domnic Martyres, Ralf Anderskewitz, Christoph Hoenke, Jan Kriegl, Thorsten Oost, Wolfgang Rist, Peter Seither
  • Solubility enhancer and use thereof
    Patent number: 9186338
    Abstract: Disclosed herein is a novel solubility enhancer capable of being employed in formulating safe and effective pharmaceutical formulations of partially soluble drugs, wherein the solubility enhancer is selected from dialkyl substituted amides of fatty acids having C6 to C16 carbon chain, preferably from N,N-dimethyl hexanamide, N,N-dimethyl octanamide, N,N-dialkyl decanamide, N,N-dialkyl dodecanamide or N,N-dialkyl hexadecanamide.
    Type: Grant
    Filed: September 22, 2006
    Date of Patent: November 17, 2015
    Inventor: Ramachandran Radhakrishnan
  • Bexarotene analogs
    Patent number: 9174917
    Abstract: The present invention relates to analogs of bexarotene and methods of use thereof.
    Type: Grant
    Filed: February 17, 2011
    Date of Patent: November 3, 2015
    Assignee: Arizona Board of Regents on Behalf of Arizona State University
    Inventors: Carl E. Wagner, Peter W. Jurutka, Pamela A. Marshall, Arjan van der Vaart
  • Cyanoisoquinoline compounds and methods of use thereof
    Patent number: 9174976
    Abstract: The present invention relates to cyanoisoquinoline compounds suitable for use in treating hypoxia inducible factor-mediated and/or erythropoietin-associated conditions.
    Type: Grant
    Filed: May 28, 2014
    Date of Patent: November 3, 2015
    Assignee: FIBROGEN, INC.
    Inventors: Michael Arend, Lee A. Flippin, Min Wu, Eric D. Turtle, Wen-Bin Ho, Shaojiang Deng
  • Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
    Patent number: 9156812
    Abstract: The present disclosure generally relates to a crystalline form of 6-[(4S)-2-methyl-4-(naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine. The present disclosure also generally relates to pharmaceutical compositions comprising the crystalline form, as well of methods of using a crystalline form in the treatment of depression and other conditions and methods for obtaining such crystalline form.
    Type: Grant
    Filed: March 18, 2013
    Date of Patent: October 13, 2015
    Assignees: Bristol-Myers Squibb Company, Albany Molecular Research, Inc.
    Inventors: Jun Qiu, Qi Gao, Shuang Liu, Min Hu, Yuh-Lin Allen Yang, Matthew Isherwood, Rasidul Amin
  • Inhibition of glycerol-3-phosphate acyltransferase (GPAT) and associated enzymes for treatment of viral infections
    Patent number: 9149445
    Abstract: A method of treating or preventing a viral infection in a mammal by administering a compound or pharmaceutically acceptable derivative thereof that inhibits a phosphatidic acid synthesis enzyme.
    Type: Grant
    Filed: July 27, 2010
    Date of Patent: October 6, 2015
    Assignee: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Sean Liu, Joshua D. Rabinowitz, Thomas Shenk
  • Tetrahydroisoquinolin-1-one derivative or salt thereof
    Patent number: 9150541
    Abstract: To provide a pharmaceutical, in particular a compound which can be used as a therapeutic agent for irritable bowel syndrome (IBS). It was found that a tetrahydroisoquinolin-1-one derivative having an amide group at the 4-position or a pharmaceutically acceptable salt thereof has an excellent bombesin 2 (BB2) receptor antagonistic action. It is also found that the tetrahydroisoquinolin-1-one derivative is highly effective on bowel movement disorders. From the above, the tetrahydroisoquinolin-1-one derivative of the present invention is useful as a therapeutic agent for diseases associated with a BB2 receptor, in particular IBS.
    Type: Grant
    Filed: July 15, 2013
    Date of Patent: October 6, 2015
    Assignee: Seldar Pharma Inc.
    Inventors: Hiroyuki Hisamichi, Itsuro Shimada, Tsukasa Ishihara, Tomofumi Takuwa, Takafumi Shimizu, Noriko Ishikawa, Kyoichi Maeno, Norio Seki
  • Inhibitors of hemeprotein-catalyzed lipid peroxidation
    Patent number: 9133212
    Abstract: Methods and compounds for the treatment or prevention of oxidative damage in a mammalian subject. The treatment and/or prevention may be on inhibiting heme-induced lipid peroxidation. Also discloses are methods and compounds for treating or preventing isoprostane-mediated tissue damage.
    Type: Grant
    Filed: February 5, 2013
    Date of Patent: September 15, 2015
    Assignee: Vanderbilt University
    Inventors: John A. Oates, L. Jackson Roberts, Ned A. Porter, Olivier Boutaud
  • Use of non-steroidal anti-inflammatory drugs by inhalation in the treatment of acute and chronic bronchitis
    Patent number: 9132109
    Abstract: A method for treating non-asthmatic bronchitis with a particular lysine acetylsalicylate is described. The lysine acetylsalicylate is delivered by nebulizer, preferably, to treat acute bronchitis, chronic bronchitis, emphysema and chronic obstructive pulmonary disease.
    Type: Grant
    Filed: March 10, 2006
    Date of Patent: September 15, 2015
    Assignee: MEDESTEA RESEARCH & PRODUCTION S.P.A.
    Inventors: Jose Sebastian Franzone, Sebastiano Bianco, Giuseppe Zuccari, Claudio Franco Omini
  • Therapeutic combination comprising a Cdc7 inhibitor and an anti-neoplastic agent
    Patent number: 9119877
    Abstract: The present invention provides a therapeutic combination comprising (a) a compound of formula (I) as set forth in the specification and (b) one or more antineoplastic agents selected from the group consisting of an alkylating or alkylating-like agent, an antimetabolite agent, a topoisomerase I inhibitor, a topoisomerase II inhibitor, an inhibitor of a growth factor or of a growth factor receptor, an antimitotic agent, a proteasome inhibitor, an inhibitor of an anti-apoptotic protein and an antibody directed against a cell surface protein, wherein the active ingredients are present in each case in lice form or in the form of a pharmaceutically acceptable salt or any hydrate thereof.
    Type: Grant
    Filed: November 17, 2010
    Date of Patent: September 1, 2015
    Assignee: NERVIANO MEDICAL SCIENCES S.R.L.
    Inventors: Dario Ballinari, Antonella Ciavolella, Enrico Pesenti, Alessia Montagnoli
  • Method for the treatment or prevention of lower urinary tract symptoms
    Patent number: 9114106
    Abstract: This invention concerns a method for treatment or prevention of lower urinary tract symptoms with or without pelvic pain in an individual, said method comprising administering to the individual an effective amount of a selective estrogen receptor modulator, or an isomer, isomer mixture or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: January 15, 2015
    Date of Patent: August 25, 2015
    Assignee: HORMOS MEDICAL LTD.
    Inventors: Risto Santti, Tomi Streng
  • Protection and treatment against influenza infection
    Patent number: 9095579
    Abstract: Method and composition for protection and treatment against influenza viral infection by modulating the activity of at least one essential host signaling pathways, including the Hedgehog (Hh), the Bone Morphogenetic Protein (BMP), the Notch (N) signaling pathways or combinations thereof, which activity is altered by the viral protein NS1. The method and composition comprise use of a compound that modulates at least one of these essential host signaling pathways for preventing or controlling symptoms associated with influenza viral infection. The method or composition can also be used either alone or in combination with other therapeutic agents for treating or protecting against influenza infection, and associated syndromes.
    Type: Grant
    Filed: February 7, 2013
    Date of Patent: August 4, 2015
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE SCRIPPS RESEARCH INSTITUTE
    Inventors: Ethan Bier, Margery Smelkinson, Robert Krug, Meghana Malur, Michael Oldstone, John Teijaro
  • Methods for treating depression, neurodegeneration, inhibiting amyloid ? deposition, delaying senescence, and extending life spans with heterocyclic compounds
    Patent number: 9089561
    Abstract: Disclosed is an antidepressant, neuroprotectant, amyloid ? deposition inhibitor, or age retardant composition containing a heterocyclic compound having the general formula (I):
    Type: Grant
    Filed: February 12, 2014
    Date of Patent: July 28, 2015
    Assignee: ZENYAKU KOGYO KABUSHIKI KAISHA
    Inventors: Yoshimasa Yamaguchi, Toshiyuki Matsuno, Kenichi Saitoh
  • Compositions and method for treating infection in cattle and swine
    Patent number: 9084719
    Abstract: Novel formulations containing a fluorinated chloramphenicol or thiamphenicol derivative antibiotic such as florfenicol, and methods for using such formulations in the treatment and prevention of infectious diseases of bovines and swine, including bovine respiratory disease.
    Type: Grant
    Filed: September 2, 2011
    Date of Patent: July 21, 2015
    Assignee: Intervet Inc.
    Inventors: Keith A. Freehauf, Allan Weingarten, Robert D. Simmons, Kanwal Jit Varma