Abstract: A system and method for modulating optogenetic vagus neurons in a noninvasive and transcutaneous manner is disclosed. The system and method comprises a two-dimensional array of organic light emitting diodes (OLEDs), a voltage-generating unit, a control unit, and a feedback loop. The array is placed on a subject's outer ear. Because the array is flexible, it can be closely placed on the skin of the outer ear. The array can deliver optical therapy and monitor heart rate variability (HRV) of the subject simultaneously, and the pixels of the array can be individually addressed. The voltage-generating unit generates pulsed voltage to the OLEDs. The control unit is connected to the array and controls the array and therapeutic patterns. The feedback loop uses the HRV to identify the therapeutic patterns.

Abstract: An ophthalmic laser surgical system uses a confocal detector assembly to continuously detect a confocal signal during laser treatment, and based on the confocal signal, detects in real time a loss of tissue contact with the patient interface (PI) output surface. The detection is partly based on the change of reflectivity at the PI output surface when the optical interface changes from a lens-tissue interface to a lens-air interface. The behavior of the confocal signal upon loss of tissue contact is dependent on the treatment laser scan pattern being performed at the time of tissue contact loss. Thus, different confocal signal analysis algorithms are applied to detect tissue contact loss during different scans, such as the bed cut and side cut for a corneal flap. The real time confocal signal may also be used during eye docking to detect the establishment of tissue contact with the PI output surface.

Abstract: The present invention relates to a minimally invasive surgical instrument having an articulation immobilising structure. The present invention is a s minimally invasive surgical instrument and includes a shaft, an end effector connected towards one end of the shaft, a wire for controlling the articulated movement of the end effector, and an immobilising structure adapted to immobilise the state of articulated movement of the end effector. The immobilising structure includes a resilient member covering the wire, and the resilient member holds the wire when an internal space therein contracts.

Abstract: Methods and apparatus for monitoring a subject are described. A monitoring device configured to be attached to a body of a subject includes a sensor that is configured to detect and/or measure physiological information from the subject and at least one motion sensor configured to detect and/or measure subject motion information. The physiological sensor and motion sensor are in communication with a processor that is configured to receive and analyze signals produced by the physiological sensor and motion sensor. The processor is configured to process motion sensor signals to identify an activity characteristic of the subject.

Abstract: A medical or dental instrument part having a coupling device for connecting the instrument part to a control, regulating or supply unit, a memory device that can be operated with electrical power for storing identification data and/or operating and/or care data of the instrument part and at least one electrical line, which is provided for supplying electrical power to a lighting device that is provided on the instrument part or can be connected to the instrument part for operating the lighting device and for supplying electrical power to the memory device for operating the memory device. In addition, a medical or dental treatment device having such a medical or dental instrument part and a corresponding method for supplying electrical power to a lighting device and to a memory device by at least one electrical line are provided.

Abstract: A system for monitoring autoregulation may include processing circuitry configured to receive a blood pressure signal indicative of an acquisition blood pressure of a patient at an acquisition site and an oxygen saturation signal indicative of an oxygen saturation of the patient. The processing circuitry may determine a cerebral autoregulation status value based on the blood pressure signal and the oxygen saturation signal. The processing circuitry may determine a non-cerebral autoregulation status value based on the cerebral autoregulation status value and an adjustment value. The processing circuitry provide to an output device a signal indicative of the non-cerebral autoregulation status value and a signal indicative of the cerebral autoregulation status value to enable a clinician to monitor the autoregulation status of the patient.

Abstract: An NIR light emitting device has a flat NIR light emitter attached to a distal end of a heat pipe on its lower side and an optically-transparent, thermal insulator on its upper side. The proximal end of the heat pipe is thermally connected to a cooling element. The light emitter is connected to a power source to irradiate NIR light.

Abstract: A treatment device for a scalp including a body that defines an exterior design and has one surface in which a plurality of light irradiation holes are formed, a light generation unit provided in the body and a beam splitter that dividedly refractionates light generated in the light generation unit into a plurality of lights and guides the lights toward the plurality of the light irradiation holes and a travel direction of the light generated in the light generation unit is different from a travel direction of the light passing the beam splitter.

Abstract: A driveline for an implantable blood pump including a percutaneous outer tube configured to connect with the blood pump when the blood pump is implanted within a body of a patient and an external controller outside of the body of the patient and at least one ultra-violet light emitter coupled to the outer tube.

Abstract: An apparatus for microdisruption of cataracts in lens tissue by impulsive heat deposition comprising: a source of pulsed laser radiation, a user input device, a control circuit, and an optical waveguide configured to transmit the pulsed laser radiation. The light intensity which exits the optical waveguide has a wavelength selected to match an absorption peak of at least one component of the lens tissue, a pulse duration time shorter than a time required for thermal diffusion out of the laser irradiation volume and shorter than a time required for a thermally driven expansion of the laser irradiated volume, and a pulse energy resulting in a peak intensity of each laser pulse below a threshold for ionization-driven ablation to occur.

Abstract: The present disclosure relates to hand held powered surgical devices, loading unit detection assemblies, surgical adapters and/or adapter assemblies for use between and for interconnecting the powered surgical device or handle assembly and an end effector for clamping, cutting, stapling and/or sealing tissue.

Abstract: A device for treating the brain includes a light source configured to emit near infrared light. The device also includes a collimator configured to receive the near infrared light emitted by the light emitter. The collimator is further configured to collimate the near infrared light. The device also includes an optic configured to focus collimated light. A reflector of the device is configured to change a direction of the collimated light. The reflector is at a distal end of the device, and the distal end is configured to fit between an upper portion of an eyelid of a patient and an orbital socket of the patient.

Abstract: A method, apparatus, and system for measuring respiratory effort of a subject are provided. According to the method, a thoracic effort signal (T) is obtained, the thoracic effort signal (T) being an indicator of a thoracic component of the respiratory effort. An abdomen effort signal (A), the abdomen effort signal (A) being an indicator of an abdominal component of the respiratory effort. A respiratory flow (F) is obtained. The respiratory effort is determined by adjusting the components of a model of the respiratory system based on the thoracic effort signal (T), the abdomen effort signal (A), or the respiratory flow (F) or any combination of the thoracic effort signal (T), the abdomen effort signal (A), and the respiratory flow (F).

Abstract: A component (14) for a medical instrument includes a shaft (15), a transmission device (16), which is movable in the shaft (15), for transmitting a force from a manipulation device (18) coupled to the proximal end of the component (14) to a tool (13) at the distal end of the component (14), an abutment surface (86) on the shaft (15), and an abutment surface (36) on the transmission device (16). The abutment surface (86) of the shaft (15) and the abutment surface (36) of the transmission device (16) are arranged such that a mechanical contact between the abutment surface (36) of the transmission device (16) and the abutment surface (86) of the shaft (15) limits a movement of the transmission device (16) relative to the shaft (15) in the proximal direction.

Abstract: A method for minimally invasive laser ablation of a target tissue within a patient while sparing tissue within a safety zone proximate to the target tissue, comprising: guiding a laser fiber within a patient with a guidance tool; measuring a temperature within the target tissue and the safety zone based on an invasive and a non-invasive thermal sensor; computing a thermal profile in conjunction with a real-time tissue image adapted for guidance of the laser fiber with the guidance tool within the patient; and controlling a laser to deliver energy through the laser fiber, to deliver a minimally therapeutic ablation therapy to the target tissue while ensuring that the safety zone is maintained in a non-ablation condition, based on at least a treatment plan, the measured temperature, and the thermal profile.

Abstract: Various implantable device embodiments may comprise a neural stimulator configured to deliver a neurostimulation therapy to stimulate tissue. A prescribed dose of the neurostimulation therapy relates to a therapeutically-effective and safe amount of charge delivered to the stimulated tissue over a period of time. The neural stimulator may include a power supply used to deliver the neurostimulation therapy, and a charge/current monitor configured to monitor a delivered dose of the neurostimulation therapy with respect to the prescribed dose to determine whether the delivered dose is delivering the therapeutically-effective and safe amount of charge to the stimulated tissue over the period of time.

Abstract: A light based skin treatment device (10, 20) is provided, comprising a light source (18) for providing an incident light beam (21) for treating a skin (30) by laser induced optical breakdown (LIOB) of hair or skin tissue, a transparent exit window (14) for allowing the incident light beam (21) to exit the device (10, 20), and an optical system for focusing the incident light beam (21) into a focal spot (221, 222) in the hair or skin tissue outside the skin treatment device (10, 20).

Abstract: A driveline for an implantable blood pump including a percutaneous connector including an outer tube, the outer tube defining an exterior surface and having a proximal portion and a distal portion opposite the proximal portion, the proximal portion being couplable to the implantable blood pump disposed within a body of a patient and the distal portion being couplable to a controller outside of the body of the patient and at least one electronic instrument coupled to the outer tube and fluidically sealed from the exterior surface.

Abstract: A phototherapy device comprises a face mask having a rigid (or semi-rigid) shell contoured to the human face. A flexible array of LEDs is affixed to the inner surface of the mask. A flexible, quantum dot-containing film is situated over the flexible array of LEDs. The quantum dots in the QD-containing film are selected to photo-luminesce at one or more particular wavelengths in response to photoexcitation by the light emitted from the LEDs. The LEDs emit “primary light” and the quantum dots down-convert at least a portion of the primary light to “secondary light.” The flexible, quantum dot-containing film may be interchangeable such that the wavelength(s) of the secondary light may be tailored to various phototherapy treatment regimes.

Abstract: Modular physiological sensors that are physically and/or electrically configured to share a measurement site for the comfort of the patient and/or to ensure proper operation of the sensors without interference from the other sensors. The modular aspect is realized by providing outer housing shapes that generally conform to other physiological sensors; mounting areas for attachment of one sensor to another sensor; providing release liners on the overlapping sensor attachment areas; and/or providing notches, tabs or other mechanical features that provide for the proper placement and interaction of the sensors.