Patents Examined by Zinna N. Davis
  • Substituted tetrahydro-2H-isoquinolin-1-one derivatives, and methods for the production and use thereof
    Patent number: 7795278
    Abstract: This invention relates to compounds according to the general formula (I), where the definitions of the substituents R1, R2, Ar and X are as specified in the description, and to their physiologically tolerated salts, methods for the preparation of these compounds and their use as medicaments. These compounds are poly(ADP-ribose) polymerase (PARP) inhibitors.
    Type: Grant
    Filed: December 6, 2006
    Date of Patent: September 14, 2010
    Assignee: sanofi-aventis Deutschland GmbH
    Inventors: Stefan Peukert, Stefan Guessregen, Armin Hofmeister, Herman Schreuder, Uwe Schwahn
  • 7-(2-(4-(3-trifuloromethyl-phenyl)-1,2,3,6-tetrahydropyrid-1-yl)ethyl)isoquinoline besylate salt, preparation and therapeutic use thereof
    Patent number: 7795277
    Abstract: The present invention relates to the besylate salt of 7-(2-(4-(3-(trifluoromethyl)phenyl)-1,2,3,6-tetrahydropyrid-1-yl)ethyl)isoquinoline, to its preparation and to its use in therapeutics. The salt may be represented by the formula (II) below.
    Type: Grant
    Filed: September 12, 2007
    Date of Patent: September 14, 2010
    Assignee: sanofi-aventis
    Inventors: Corinne Barre, Olivier Monnier
  • Substituted 4-phenyltetrahydroisoquinolines, pharmaceutical compositions thereof, methods for their preparation and therapeutic use
    Patent number: 7790742
    Abstract: The present invention relates to substituted 4-phenyltetrahydroisoquinoline compounds of the structure of formula I and pharmaceutical compositions comprising them wherein the R groups are herein defined. These are excellent inhibitors of the sodium-hydrogen exchanger (NHE), in particular of the sodium-hydrogen exchanger of subtype 3 (NHE3). As such these compounds are useful in the treatment of various disorders of the renal and respiratory systems such as acute or chronic renal failure, pulmonary complications, biliary function disorders, respiratory disorders such as snoring or sleep apneas and cardiovascular/central nervous system disorders such as stroke.
    Type: Grant
    Filed: March 1, 2007
    Date of Patent: September 7, 2010
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Hans-Jochen Lang, Uwe Heinelt, Klaus Wirth, Thomas Licher, Armin Hofmeister
  • Tetrahydroisoquinoline LXR Modulators
    Patent number: 7790745
    Abstract: A compound of formula I wherein X, R1, R2a, R3a, R3b, R4a, R4b, R4c and R5 are defined herein.
    Type: Grant
    Filed: October 18, 2006
    Date of Patent: September 7, 2010
    Assignee: Bristol-Myers Squibb Company
    Inventors: Wu Yang, Yufeng Wang, Ellen K. Kick
  • c-fms kinase inhibitors
    Patent number: 7790724
    Abstract: The invention is directed to compounds of Formula II: wherein A, R1, R2, R3, R4, X, Y and W are set forth in the specification, as well as solvates, hydrates, tautomers or pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase.
    Type: Grant
    Filed: April 20, 2006
    Date of Patent: September 7, 2010
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Mark R. Player, Nand Baindur, Benjamin Brandt, Naresh Chadha, Raymond J. Patch, Davoud Asgari, Taxiarchis M. Georgiadis
  • Amide derivatives
    Patent number: 7786115
    Abstract: The invention concerns a compound of the Formula I wherein m is 0-2 and each R1 is a group such as hydroxy, halogeno, trifluoromethyl heterocyclyl and heterocyclyloxy; R2 is halogeno, trifluoromethyl or (1-6C)alkyl; R3 is hydrogen, halogeno or (1-6C)alkyl; and R4 is (3-6C)cycloalkyl;or pharmaceutically-acceptable salts thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by cytokines.
    Type: Grant
    Filed: December 22, 2005
    Date of Patent: August 31, 2010
    Assignee: AstraZeneca AB
    Inventors: Ian Alun Nash, Kenneth Mark Page, Paul Allen Bethel
  • Pyridones useful as inhibitors of kinases
    Patent number: 7786120
    Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
    Type: Grant
    Filed: August 25, 2006
    Date of Patent: August 31, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Jean-Damien Charrier, Sharn Ramaya, Steven Durrant, Juan-Miguel Jimenez, Julian M. C. Golec, Michael Mortimore
  • Bicyclic derivatives as modulators of ion channels
    Patent number: 7786137
    Abstract: Bicyclic derivatives having formula (I) and a composition thereof are useful as ion channel antagonists:
    Type: Grant
    Filed: May 8, 2006
    Date of Patent: August 31, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Aarti S. Kawatkar, Tara M. Whitney, Timothy D. Neubert, Nicole Zimmermann, Andreas Termin, Esther Martinborough
  • Pyridones useful as inhibitors of kinases
    Patent number: 7786130
    Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
    Type: Grant
    Filed: August 28, 2006
    Date of Patent: August 31, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Jean-Damien Charrier, Sharn Ramaya, Steven Durrant, Juan-Miguel Jimenez, Guy Brenchley, Ronald Knegtel, Michael Mortimore
  • Isoquinolinone potassium channel inhibitors
    Patent number: 7781457
    Abstract: The present invention relates to compounds having the structure formula (I) useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.
    Type: Grant
    Filed: September 22, 2004
    Date of Patent: August 24, 2010
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Richard Isaacs, Christopher J. Dinsmore, Charles J. McIntyre, Linda S. Payne, David A. Claremon
  • Derivatives of pyridine and quinoline
    Patent number: 7781458
    Abstract: The invention provides compounds of formula I blocking phosphorylcholine biosynthesis by means of the selective blocking of the choline kinase enzyme in tumor cells or in cells affected by parasitic infection and therefore being applicable in the treatment of tumors and parasitic diseases or diseases produced by viruses and fungi in animals, including human beings; as well as to a method for preparing the compounds of the invention and certain intermediates of said method.
    Type: Grant
    Filed: January 11, 2005
    Date of Patent: August 24, 2010
    Assignees: Consejo Superior de Investigaciones Cientificas, Universidad de Granada
    Inventors: Juan Carlos Lacal Sanjuán, Joaquin Campos Rosa, Miguel Ángel Gallo Mezo, Antonio Espinosa Úbeda
  • Substituted 1,2,3,4-tetrahydroisoquinoline derivatives
    Patent number: 7763638
    Abstract: The invention relates to novel 1,2,3,4-tetrahydroisoquinoline derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and methods of treatment comprising administration of said compounds to a mammal.
    Type: Grant
    Filed: February 23, 2005
    Date of Patent: July 27, 2010
    Assignee: Actelion Pharmaceuticals Ltd.
    Inventors: Hamed Aissaoui, Martine Clozel, Walter Fischli, Ralf Koberstein, Thomas Weller
  • Isoquinoline potassium channel inhibitors
    Patent number: 7763614
    Abstract: The present invention relates to compounds of structural formula I: I useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.
    Type: Grant
    Filed: September 22, 2004
    Date of Patent: July 27, 2010
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Richard Isaacs, Christopher J. Dinsmore, B. Wesley Trotter, Nigel Liverton, Douglas C. Beshore, Nathan R. Kett, Charles J. McIntyre, Kausik K. Nanda, David A. Claremon
  • Targeted, NIR imaging agents for therapy efficacy monitoring, deep tissue disease demarcation and deep tissue imaging
    Patent number: 7754884
    Abstract: Compounds and methods related to NIR molecular imaging, in-vitro and in-vivo functional imaging, therapy/efficacy monitoring, and cancer and metastatic activity imaging. Compounds and methods demonstrated pertain to the field of peripheral benzodiazepine receptor imaging, metabolic imaging, cellular respiration imaging, cellular proliferation imaging as targeted agents that incorporate signaling agents.
    Type: Grant
    Filed: June 10, 2005
    Date of Patent: July 13, 2010
    Assignee: Vanderbilt University
    Inventors: Darryl J. Bornhop, H. Charles Manning, Mingfeng Bai, Shelby K. Wyatt
  • Compounds and compositions as PPAR modulators
    Patent number: 7745445
    Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families, particularly the activity of PPAR?.
    Type: Grant
    Filed: May 13, 2005
    Date of Patent: June 29, 2010
    Assignee: IRM LLC
    Inventors: Robert Epple, Mihai Azimioara
  • Compositions and methods for reducing the risk of epileptic occurrence and/or for treatment of seizure disorders
    Patent number: 7745426
    Abstract: The present invention relates to compounds and compositions useful for reducing the risk of epileptic occurrences and/or for alleviating epileptic phenomena in patients. In accordance with the invention, the compounds and compositions have at least the following two components: a) vitamin B6-based component selected from pyridoxal, pyridoxamine, pyridoxine, their pharmaceutically acceptable functional derivatives and salts; and b) at least one antiepileptic drug (AED) or anticonvulsive, neuro-protective drug or nootrope compound or moiety. The invention further relates to methods for preventing epileptic episodes and for alleviating epileptic episodes, as well as methods for reducing side effects of antiepileptic drugs.
    Type: Grant
    Filed: August 12, 2004
    Date of Patent: June 29, 2010
    Assignees: D-Pharm Ltd., Advanced Neuroprotective Systems Ltd.
    Inventors: Svetlana Dolina, Vitaly Shteiman, Marina Vinnikova, Israel Shapiro
  • Process for producing 2-(phenyl methyl thio)-3-pyridine carboxylic acid
    Patent number: 7745631
    Abstract: The invention discloses an improved process for producing an intermediate to produce large quantity of 2-(Phenyl methyl thio)-3-pyridine carboxylic acid. The process comprises reacting 2-chloro-3-cyanopyridine with benzyl mercaptan in presence of a base and an aprotic solvent. The resulting intermediate 2-(phenyl methyl thio)-3-cyanopyridine is hydrolyzed in presence of a base in an autoclave and isolated under acidic condition to get the desired product.
    Type: Grant
    Filed: June 17, 2004
    Date of Patent: June 29, 2010
    Assignee: Jubilant Organosys Limited
    Inventors: Shailendra Kumar Singh, Ashutosh Agarwal
  • Isoquinolinone potassium channel inhibitors
    Patent number: 7741322
    Abstract: The present invention relates to compounds having the structure (I) useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.
    Type: Grant
    Filed: September 17, 2004
    Date of Patent: June 22, 2010
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Christopher J. Dinsmore, Jeffrey M. Bergman, Charles J. McIntyre, Richard Isaacs, David A. Claremon
  • Dipeptidyl peptidase inhibitors
    Patent number: 7732446
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV inhibitors comprising Formulae: where the substituents are as described herein.
    Type: Grant
    Filed: March 9, 2005
    Date of Patent: June 8, 2010
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Stephen L. Gwaltney, Jeffrey A. Stafford, Michael B. Wallace, Laurence E. Burgess, Scott D. Cowen, Stephen S. Gonzales, Ellen R. Laird, Xiaodong Wang
  • Thiophene derivatives which are HM74A agonists
    Patent number: 7732452
    Abstract: The invention is concerned with novel substituted thiophene derivatives of formula (I) wherein R1 to R8, X, m and n are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds are HM74A agonists and can be used as medicaments.
    Type: Grant
    Filed: December 13, 2006
    Date of Patent: June 8, 2010
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Henrietta Dehmlow, Uwe Grether, Nicole A. Kratochwil, Robert Narquizian, Constantinos G. Panousis