Patents Examined by Zohreh Vakili
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Patent number: 7700615Abstract: Methods for treating an individual having cancer are provided. The method may include administering a cell migration inhibitor and a chemotherapeutic agent to the individual to inhibit migration of cancer cell. Inhibiting cell migration may increase cell division. In this manner, the cell migration inhibitor and the chemotherapeutic agent in combination may have increased efficacy compared to the chemotherapeutic agent alone due to the increased cell division. The cell migration inhibitor may include any of the inhibitors described herein. For example, the cell migration inhibitor may be an organic molecule having a molecular weight of less than about 700, a monoclonal antibody, or a natural product.Type: GrantFiled: February 1, 2006Date of Patent: April 20, 2010Assignee: Avolix Pharmaceuticals, Inc.Inventors: David L. Edwards, Michael E. Berens, Christian Beaudry
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Patent number: 7700077Abstract: The invention concerns the use for treating and cleaning the eye and its appendages of aqueous ionic solutions obtained from sea water whereof the ionic composition is qualitatively that of sea water and quantitatively such that their pH ranges between 4 and 9, preferably between 7 and 8 and their osmolality ranges between 150 and 700, preferably between 250 and 350 mOsm/kg.Type: GrantFiled: May 23, 2005Date of Patent: April 20, 2010Assignee: Laboratories de la MerInventors: Jean-Claude Yvin, Benedicte Marie Dominique Halley, Didier Leroy
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Patent number: 7666909Abstract: D-glyceric acid has been found to enhance alcohol metabolism and thereby prevent adverse effects of alcohol consumption. D-glyceric acid is administered concurrently with alcohol, to accelerate the elimination of the alcohol from the body. D-glyceric acid is converted into D-glyceraldehyde and further into glycerol in reactions catalysed by NADH-aldehyde dehydrogenase and NADH-alcohol dehydrogenase complexes, which are produced in excess during alcohol oxidation, in the cells of alcohol-metabolising tissues. In these reactions, the NADH complexes become NAD-aldehyde dehydrogenase and NAD-alcohol dehydrogenase complexes. These complexes in turn accelerate the oxidation of alcohol, which is paralleled by enhancement of acetaldehyde oxidation to metabolically harmless acetic acid. D-glyceric acid or its salt or ester is used for the manufacture of a pharmaceutical preparation for enhancing the metabolism of alcohol.Type: GrantFiled: April 13, 2005Date of Patent: February 23, 2010Inventor: Pekka Heino
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Patent number: 7662786Abstract: Compounds of the present invention include cell growth inhibitors which are peptides of Formula I, A-B-D-E-F-(G)r-(K)s-L ??(I), and acid salts thereof, wherein A, B, D, E, F, G and K are ?-amino acid residues, and s and r are each, independently, 0 or 1. L is a monovalent radical, such as, for example, an amino group, an N-substituted amino group, a ?-hydroxylamino group, a hydrazido group, an alkoxy group, a thioalkoxy group, an aminoxy group, or an oximato group. The present invention also includes a method for treating cancer in a mammal, such as a human, comprising administering to the mammal an effective amount of a compound of Formula I in a pharmaceutically acceptable composition.Type: GrantFiled: April 18, 2006Date of Patent: February 16, 2010Assignee: Abbott GmbH & Co. KGInventors: Bernd Janssen, Teresa Barlozzari, Andreas Haupt, Thomas Zierke, Andreas Kling
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Patent number: 7659278Abstract: The present invention provides novel compounds, corresponding to formulae I and II, respectively, which are able to reactivate the apoptosis-inducing function of mutant p53 proteins. This reactivation is provided by restoration of sequence-specific DNA-binding activity and transcriptional transactivation function to mutant p53 proteins, and modulation of the conformation-dependent epitopes of the p53 protein. Accordingly, the substances according to the invention will be used in pharmaceutical compositions and methods for treatment of patients suffering from various types of tumours.Type: GrantFiled: February 7, 2003Date of Patent: February 9, 2010Assignee: Aprea ABInventors: Vladimir Bykov, Galina Selivanova, Klas Wiman
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Patent number: 7655255Abstract: The present invention relates to a topical composition for transdermal administration, wherein main components of the composition comprises vitamin C, vitamin B complex, carotene, and vitamin E, and may further comprise a fragrance, a thickening agent and a surfactant. The pharmaceutical composition is for topical application and is useful in skin-care and for the treatment of acne, comedo and zit. The composition also has an antioxidant property.Type: GrantFiled: March 26, 2004Date of Patent: February 2, 2010Assignee: HenKan Pharmaceutical Co., Ltd.Inventors: BuSang Liu, TongHo Lin
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Patent number: 7645750Abstract: A method for treating or preventing symptoms of hormonal variation includes administering an effective amount of a receptor antagonist to a subject having one or more symptoms of hormonal variations, wherein the receptor antagonist binds to at least one selected from the group consisting of a serotonin type 2A (5-HT2A) and a dopamine type 2 (D2) receptors.Type: GrantFiled: December 13, 2006Date of Patent: January 12, 2010Assignee: Yung Shin Pharmaceutical Ind. Co., Ltd.Inventor: Hung-Ming Wu
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Patent number: 7592372Abstract: Liquid drug preparations characterized by containing fudostein and an acid together with a sweetener such as sugar alcohol, trehalose or a sweetener having a high degree of sweetness. These liquid drug preparations are fudostein-containing liquid drug preparations which are free from color change or sedimentation upon prolonged storage and can be easily taken.Type: GrantFiled: May 24, 2002Date of Patent: September 22, 2009Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Tomohiko Osugi, Masunari Fushimi, Yutaka Murata, Tetsuo Kaneko, Katsumi Imamori
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Patent number: 7547673Abstract: The present invention relates to methods of treating a cancerous tumor using selective inhibitors of ATP production. The present invention also relates to pharmaceutical preparations comprising such inhibitors and methods for administering them intraarterially directly to a tumor, as well as methods for identifying compositions that selectively inhibitor ATP production for use in the invention.Type: GrantFiled: September 13, 2002Date of Patent: June 16, 2009Assignee: The Johns Hopkins UniversityInventors: Young He Ko, Jean-Francois H. Geschwind, Peter L. Pedersen
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Patent number: 7538123Abstract: The present invention relates to a compound represented by the following formula, a pharmacologically acceptable salt thereof, or a use thereof as a pharmaceutical: wherein R1 and R2 are substituents adjacent to each other, and together with two carbon atoms to each of which they attach, form a 5- to 7-membered non-aromatic carbocyclic group or the like, which may be substituted by 1 to 4 substituents selected from (1) an oxo group, (2) a hydroxyl group, and the like; R3 represents a hydrogen atom or the like; and R6 represents a hydrogen atom or the like. This compound has a superior strength of binding to a 5-HT1A receptor and an antagonism to the receptor, and is useful as an agent for treating or preventing lower urinary tract symptoms, and particularly symptoms regarding urinary storage.Type: GrantFiled: May 11, 2005Date of Patent: May 26, 2009Assignee: Eisai R & D Management Co., Ltd.Inventors: Yuichi Suzuki, Koichi Ito, Atsushi Sasaki, Koshi Ueno, Miyuki Sakai, Hiroki Ishihara, Atsuhiko Kubota
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Patent number: 7470715Abstract: The present application is directed to a new class of isoxazoles and their use as estrogen modulators.Type: GrantFiled: December 19, 2006Date of Patent: December 30, 2008Assignee: Pfizer Inc.Inventors: Simon Bailey, Stephen Douglas Barrett, Raj Kumar Raheja, Veerabahu Shanmugasundaram
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Patent number: 7416720Abstract: The present invention is based upon the surprising discovery that the offering aqueous composition according to the invention is capable of being used as topical nail hardener. The present invention relates to a nail hardener that employs a composition of glycerin and water in the preferred concentration as the active components, in a solvent carrier mixture from a group of pharmaceutically acceptable solvents such as ethanol and Propylene glycol.Type: GrantFiled: September 15, 2004Date of Patent: August 26, 2008Inventor: Morteza Hajirahimy
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Patent number: 7381546Abstract: The rapamycin gene cluster is an example of a gene cluster which includes a gene (rapL) leading to the formation of a precursor compound (pipecolic acid, in this case) which is required for inclusion in the larger product (rapamycin) produced by the enzymes encoded by the cluster. We have produced a mutant strain containing a rapamycin gene cluster in which the rapL gene is disabled. The strain does not naturally produce rapamycin but does so if fed with pipecolic acid. By feeding with alternative carboxylic acids we have produced variants of rapamycins. Tests have shown biological activity.Type: GrantFiled: January 10, 2006Date of Patent: June 3, 2008Assignee: Biotica Technology LimitedInventors: Peter Francis Leadlay, James Staunton, Lake Ee Khaw
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Patent number: 7371367Abstract: A method of treating inflammatory acne vulgaris or inflammatory acne rosacea comprises the topical application of a formulation incorporating carbamide peroxide in a pharmaceutically acceptable vehicle. Inflammatory acneform lesions that can be successfully treat with the inventive method include erythematous papules, pustules, nodules, and cysts. Suitable pharmaceutical vehicles for the topical application of carbamide peroxide include creams, gels, lotions, solutions, suspensions, and ointments.Type: GrantFiled: July 23, 2004Date of Patent: May 13, 2008Assignee: Exopharma, Inc.Inventor: Joel E. Bernstein
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Patent number: 7351716Abstract: The present invention relates to a dermatologic preparation containing a diamide derivative represented by the following formula (1): (wherein, R1 represents a linear or branched hydrocarbon group having 1 to 22 carbon atoms which may be substituted by one or more hydroxy and/or alkoxy groups, R2 represents a linear or branched divalent hydrocarbon group having 1 to 12 carbon atoms, and R3 represents a linear or branched divalent hydrocarbon group having 1 to 42 carbon atoms). This diamide derivative (1) is capable of fundamentally improving the water retention capacity and barrier functions of the horny layer, is excellent in miscibility and mixing stability and can be prepared efficiently at a low cost.Type: GrantFiled: December 10, 2003Date of Patent: April 1, 2008Assignee: Kao CorporationInventors: Masahide Hoshino, Yoshiya Sugai, Akiyo Kameyama, Hiroaki Saito, Yoshinori Nishizawa, Yutaka Takagi
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Patent number: 7351723Abstract: Lyophilized pantoprazole preparations which are obtainable by freeze-drying of an aqueous solution of pantoprazole, ethylenediamine tetraacetic acid and/or a suitable salt thereof, and sodium hydroxide and/or sodium carbonate are disclosed. The preparations have advantageous properties when reconstituted for injection.Type: GrantFiled: May 28, 2004Date of Patent: April 1, 2008Assignee: Nycomed GmbHInventors: Rudolf Linder, Rango Dietrich
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Patent number: 7084110Abstract: Compounds of the present invention include cell growth inhibitors which are peptides of Formula I, A-B-D-E-F-(G)r-(K)s-L,??(I) and acid salts thereof, wherein A, B, D, E, F, G and K are ?-amino acid residues, and s and r are each, independently, 0 or 1. L is a monovalent radical, such as, for example, an amino group, an N-substituted amino group, a ?-hydroxylamino group, a hydrazido group, an alkoxy group, a thioalkoxy group, an aminoxy group, or an oximato group. The present invention also includes a method for treating cancer in a mammal, such as a human, comprising administering to the mammal an effective amount of a compound of Formula I in a pharmaceutically acceptable composition.Type: GrantFiled: September 25, 2002Date of Patent: August 1, 2006Assignee: Abbott GmbH & Co., KGInventors: Bernd Janssen, Teresa Barlozzari, Andreas Haupt, Thomas Zierke, Andreas Kling