Abstract: Disclosed are novel opthalmic solutions useful for the treatment of ocular hypertension and glaucoma. These contain mabuterol as a preferred active ingredient.

Abstract: A method is disclosed for the prevention and alleviation of pathologic changes in the eye such as diabetic retinopathy or senile macular degeneration. The claimed method involves the parenteral administration of anisodamine in an amount effective for preventing or alleviating these pathogenic changes.

Abstract: Novel compositions and methods for the attraction of spruce beetles Dendroctonus rufipennis are provided. The compositions are comprised of both insect and tree-produced semiochemicals alone or in combination to attract populations of spruce beetles. The compositions are effective for the attraction and manipulation of the spruce beetle populations.

Abstract: A method of treating a burn injury comprises administering to the injury a composition comprising petroleum wax, paraffin oil and a topically acceptable refrigerant, wherein subsequent evaporation of the refrigerant is effective to form a foam and maintain the foam at a temperature of from 0.degree. to 10.degree. C. for at least 1 minute. A suitable composition for use in the method comprises an intimate mixture of(a) petroleum wax in an amount of from 3 to 8% by weight of the composition, from 15 to 60% by weight of said wax being in microcrystalline form,(b) paraffin oil in an amount of from 6 to 15% by weight of the composition, and(c) the topically acceptable refrigerant or mixture of refrigerants.

Abstract: A pharmaceutical formulation suitable for parenteral (preferably intravenous) adminstration includes an effective amount of 1-diphenylmethyl-4-[(2-(4-methylphenyl)-5-methyl-1H-imidazol-4-yl)methyl]p iperazine and a suitable amount of an acid to generate a pharmaceutically acceptable salt having a pH above about 3.0 and a solubility above about 4.0 mg/ml. The intravenous formulation optionally includes a suitable tonicifier in a quantity sufficient to achieve isotonicity with body fluids. The salt is formed in situ during the formulation process. The slat of tartaric acid is preferred; suitable salts for lower concentration dosages are the citric acid and methane sulphonic acid salts.

Abstract: Iodine-containing germicidal preparations are provided with assured control of the content of equilibrium iodine in aqueous solution to be between 1 and 20 ppm, preferably 2-15 ppm so as to provide predetermined germicidal activity. The invention further comprises the determination of the content of equilibrium iodine in an aqueous iodophor solution by subjecting such solution to several extractions with different amounts of a water immiscible solvent for iodine, determining the concentrations of the equilibrium iodine in each of the amounts of the water immiscible solvent and extrapolating the concentration to a theoretical zero value which is a measure of the equilibrium iodine in the aqueous iodophor solution. The invention further comprises improved germicidal iodophor compositions comprising an iodophor, citric acid and iodate.

Abstract: Disclosed are nonstinging, sustained release ophthalmic formulations to control intraocular pressure in antiglaucoma therapy comprising a basic active, a cation exchange resin, and, inter alia, an acidic, mucomimetic polymer. Also disclosed are methods of treatment comprising administering such formulations topically to the eye when indicated for control and lowering of intraocular pressure.

Abstract: Methods and pharmaceutical compositions are disclosed for reducing intraocular pressure. The methods and compositions employ an active ingredient which comprises certain benzothiadiazinyl and quinazolinyl substituted carboxyalkyl dipeptides wherein the benzothiadiazinyl or quinazolinyl portions are joined to the dipeptide portions by an aminocarbonyl group.