Abstract: A locking fastener assembly comprising a fastener having a threaded portion, and a head having a first end and a second end axially spaced from the first end, the second end comprising a fastening surface and a locking washer recess. The locking fastener assembly further comprises a locking washer disposed at least partially within the locking washer recess, the locking washer comprising a locking tab extending in a first direction and a stop biased in a second direction opposing the first direction, wherein the locking tab is operable to lock rotation of the locking washer relative to an item being secured upon a torqueing rotation and a loosening rotation of the fastener. A locking member is supported by the fastener, and operable to interface with the stop of the locking washer upon the loosening rotation of the fastener to lock the fastener relative to the item being secured.

Abstract: A pressure-testing system for a tubular product. Preferably, the tubular product is a joint or a stand of production tubing. The pressure testing assembly includes a controller; a fluid reservoir configured to contain a test fluid; a pump in fluid communication with the fluid reservoir; a fluid hose having a first end configured to receive the test fluid from the reservoir, and a second end configured to be fluidically connected to a hydrotest tool for the tubular product; and a transducer. The transducer sends signals to the controller indicative of pressure within the fluid hose. The controller is programmed to automatically (i) store a pressure threshold value (T) and (ii) store a pressure test value (PT) such that when pressure in the fluid hose reaches (T) or when pressure in the fluid hose reaches (PT), the controller sends a signal to a diverter to divert a direction of fluid being pumped so that fluid is no longer pumped into tubular product.

Abstract: A surgical hub may have cooperative interactions with one of more means of displaying the image from the laparoscopic scope and information from one of more other smart devices. The surgical hub may have the capacity of interacting with these multiple displays using an algorithm or control program that enables the combined display and control of the data distributed across the number of displays in communication with the surgical hub. The hub can obtain display control parameter(s) associated with a surgical procedure. The hub may determine, based on the display control parameter, different contents for different displays. The hub may generate and send the display contents to their respective displays. For example, the visualization control parameter may be a progression of the surgical procedure. The surgical hub may determine different display contents for the primary and the secondary displays based on the progression of the surgical procedure.

Abstract: A trocar assembly that includes a trocar and a seal cartridge configured to be releasably coupled to the trocar. The seal cartridge includes a top cap that includes a main body and a latch ring. The latch ring is grounded to the main body at a first angular position and has a latch located at a second angular position angularly offset from the first angular position. Applying a radial load on the latch causes the latch ring to flex in torsion at an intermediate portion that angularly interposes the first and second angular positions.

Abstract: A surgical instrument includes a shaft assembly, an end effector, a driving assembly, at least one motor, and a motor controller. The at least one motor is configured to actuate the driving assembly to deploy staples. The motor controller is in communication with the motor. The motor controller is configured to determine whether values of first and second trigger variables exceed predetermined thresholds. The motor controller is configured to modify at least one motor control parameter in response to determining that the values of the first and second trigger variables exceed the predetermined thresholds. The motor control parameters include a motion profile instituted by the motor controller for the motor, a waiting period during which power to the motor is reduced or stopped, or the predetermined threshold relating to current or force for proximal retraction to be different from the predetermined threshold relating to current or force for distal advancement.

Abstract: A surgical stapling instrument includes a shaft assembly, an end effector at a distal end of the shaft assembly and having a first jaw with an anvil and a second jaw operable to cooperate with the first jaw to clamp tissue, and a cartridge inserted into the second jaw. The cartridge includes staples, a movable member translatable distally during a firing stroke to discharge the staples into tissue, a first sensor assembly configured to monitor a first condition of the cartridge, and a second sensor assembly configured to monitor a second condition of the cartridge. A first processor is coupled with the first and second sensor assemblies and is configured to receive first and second signals from the sensor assemblies, respectively, where each signal is indicative of the respective condition of the cartridge. The first processor is configured to selectively permit or restrict the firing stroke based upon the signals.

Abstract: Methods of operating a surgical instrument are disclosed herein.

Abstract: Provided herein are compounds, compositions, and methods for treating disorders (e.g., opioid addiction) using compounds disclosed herein, which are selective agonists of the cannabinoid 2 receptor (CB2R).

Abstract: The disclosure provides antibodies that bind human ITGAv/B1 and methods of use thereof. In some aspects, the disclosure is directed to methods of treating a cancer in a subject, comprising administering to the subject an anti-ITGAv/B1 antibody.

Abstract: A method and apparatus for a horticultural light fixture that utilizes a metallic extrusion with multiple heat pipes to distribute heat to multiple heat sink fins. The heat sink fins utilize a geometrical shape that facilitates increased air flow into an interior of the horticultural light without the use of forced air.

Abstract: Provided is an antibody composition comprising antibodies that specifically bind to 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol. Also provided is a method of making antibodies that specifically bind to 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol is provided. Further provided is a method of assaying for 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol is provided. Still further provided is a kit for detecting 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol.

Abstract: Described herein is a multilayer microporous film or membrane that may exhibit improved properties, including improved dielectric break down and strength, compared to prior monolayer or tri-layer microporous membranes of the same thickness. The preferred multilayer microporous membrane comprises microlayers and one or more lamination interfaces or barriers. Also disclosed is a battery separator or battery comprising one or more of the multilayer microporous films or membranes. The inventive battery and battery separator is preferably safer and more robust than batteries and battery separators using prior monolayer and tri-layer microporous membranes. Also, described herein is a method for making the multilayer microporous separators, membranes or films described herein.

Abstract: A system determines a baseline cyberthreat-risk score for a user, and displays the baseline cyberthreat-risk score via a user interface. The system presents at least one cyberthreat-education activity via the user interface, and receives, via the user interface, at least one user input associated with the presented at least one cyberthreat-education activity. The system generates an updated cyberthreat-risk score at least in part by updating the baseline cyberthreat-risk score based at least in part on the user input, and displays the updated cyberthreat-risk score via the user interface.

Abstract: Various cannulated bone implants and methods of using the cannulated bone implant are disclosed. The cannulated bone implant can include a proximal portion, a proximal end, a distal portion, a distal end, a transition portion, a threaded portion, a finned portion and a central passage. The transition portion can comprise a bend positioned between the proximal portion and the distal portion. The threaded portion can be positioned along the proximal portion between the proximal end and the transition portion. The threaded portion can be configured to secure the implant into a bone of a patient. The finned portion can be positioned along the distal portion between the transition portion and the distal end. The finned portion can be configured to prevent migration and/or rotation of the implant in use. The central passage can extend linearly from the proximal end of the implant to the distal end of the implant.

Abstract: A system and method for removing a backing from a ply of composite material is disclosed. The system includes a roller having a roller axis and a roller surface that circumscribes the roller axis. The system also includes an adhesion feature disposed on the roller surface. The system further includes a roller drive to move the roller along a travel path that is perpendicular to the roller axis and to rotate the roller about the roller axis.

Abstract: A surgical system may include tiered-access features. The surgical system may be used to analyze at least a portion of a surgical field. Based on a control parameter, the system may scale up or down various capabilities, such as visualization processing, endocutter communication, endocutter algorithm updates, smart cartridge connectivity, smart motor control for circular stapler, smart energy control, cloud analytics, hub connectivity control, and/or hub visualization and control interactions. The control parameter may include system aspects such as processing capability or bandwidth for example and/or the identification of an appropriate service tier.

Abstract: A system and method for removing a backing from a ply of composite material is disclosed. The system includes a roller having a roller axis and a roller surface that circumscribes the roller axis. The system also includes an adhesion feature disposed on the roller surface. The system further includes a roller drive to move the roller along a travel path that is perpendicular to the roller axis and to rotate the roller about the roller axis.

Abstract: The disclosure relates to nanoparticle drug conjugates (NDC) that comprise ultrasmall nanoparticles, folate receptor (FR) targeting ligands, and linker-drug conjugates, and methods of making and using them to treat cancer.

Abstract: A pressure bleed-off system. The system includes a fluid bypass line having an inlet and an opposing outlet, wherein the inlet is in fluid communication with a high pressure frac line for a hydraulic fracturing operation. The system also includes a high-pressure transducer located proximate the fluid inlet, a first plug valve residing along the fluid bypass line, and a first electric actuator residing on the first plug valve. The actuator is configured to rotate the first plug valve between close and open positions in response to command signals from a controller. The controller, in turn, sends the command signals in response to control signals delivered by an operator, remotely. Preferably, the command signals are wireless signals sent from outside of the red zone. The system may also include a second plug valve along the bypass line.

Abstract: Techniques and apparatuses directed to improved pawl-latching devices are described in this document. The disclosed techniques and apparatuses provide pawl-latching devices with pawls structured to avoid the sinking and warping problems present in some conventional injection molding processes. In aspects, the pawl-latching devices include a pawl having at least one of a pivot member including a notch, a release feature on the pawl spaced apart from the front and sides of the pawl, a recess defined in the top of the pawl, and/or a recess defined in the bottom of the pawl.