Abstract: An arrangement for a tailgate and rear corner window assembly of a vehicle. The vehicle includes a door envelope for pivotal attachment to a vehicle. The door envelope is positioned at a rear of the vehicle. The arrangement includes a rear window assembly having a window frame and a window glass mounted in the window frame. The rear window assembly has a latch that secures a connection with the door envelope. The arrangement also includes at least one rear corner window assembly for connection to the vehicle having a window glass mounted in a window frame. The window frame includes a bottom edge, a top edge, a side portion extending in a longitudinal direction and a rear portion that curves and extends away from the side portion. There is a latch located on an inside surface of the rear portion of the at least one rear corner window assembly.

Abstract: The present disclosure provides methods and diagnostic tools comprising classifiers and indicator cells that respond differentially to a sample derived from a subject having a disease or cancer, such as lung cancer, as compared to a control or normal sample. Also disclosed herein are methods of detecting a multicomponent gene expression readout from a genetically identical population of cells.

Abstract: The present disclosure provides, inter alia, antibody drug conjugates that are useful in treating various diseases such as cancer. The antibody drug conjugates can be configured to elicit tumor site-specific responses, including tumor microenvironment immunostimulation, while limiting off-target and systemic effects. In certain embodiments disclosed herein, the antibody drug conjugates are configured to release payloads following internalization by immune, cancer, or tumor associated cells.

Abstract: In the case of FC-NVMe (NVMe over Fabrics using Fibre Channel (FC) as a transport), zoning is typically performed using the interface WWPNs, but the masking of NVMe namespaces is performed using a host's NVMe Qualified Name (NQN or HOSTNQN). The use of two identifiers (i.e., one identifier used for zoning and another identifier used for masking) introduces a potential security related concern. A bad actor may obtain the NQN of a host that has access to sensitive information and use it to access this sensitive information. Accordingly, in one or more embodiments, by correlating different identifiers and using a combination of the different identifiers, access can easily be provided to the appropriate host adapters while prohibiting access to rogue hosts.

Abstract: An inline heater includes a heater core that includes a heat spreader assembly comprising a tubular heat spreader that extends axially along a longitudinal axis and that comprises an external surface. The heat spreader assembly includes a fluid inlet and a fluid outlet. At least one conduit extends helically about the longitudinal axis of the heat spreader between the fluid inlet and the fluid outlet to define a fluid heating flow path that fluidically connects the fluid inlet and the fluid outlet. The heat spreader assembly further comprising an electrically operated heating element for heating the heat spreader.

Abstract: Systems and methods are disclosed for a configurable interconnect address remapper with event detection. For example, an integrated circuit can include a processor core configured to execute instructions. The processor core includes region registers defined by a From Address range and a To Address, a register storing a number of regions defined in the integrated circuit, interrupt enable registers associated with each pair of region registers, and event flags associated with each pair of region registers; an interconnection system handling transactions from the processor core; an interconnect address remapper translating an address associated with a transaction using the one or more pair of region registers; and an interrupt controller receiving an interrupt signal from the interconnect address remapper when the interrupt enable registers are enabled and at least one raised event flags when at least one of the one or more pair of region registers matches the transaction address.

Abstract: This invention is directed to the treatment of cancer, particularly castration-resistant prostate cancer and osteoblastic bone metastases, with a dual inhibitor of MET and VEGF.

Abstract: A lensed display system includes a projector configured to project an image. The lensed display system includes a lens formed of a glass or crystalline material. The lens includes a first surface, wherein at least a portion of the first surface includes a coating that is configured to display the projected image. The lens includes a second surface, wherein the second surface comprises a transparent curved surface that is configured to face toward a user and to enable the user to view the image projected onto the coating through the transparent curved surface.

Abstract: CD38 is expressed on malignant plasma cells. CD28 is a costimulatory molecule required for T-cell activation and survival. Provided herein are novel anti-CD38 antibodies, anti-CD28 antibodies, and bispecific antibodies (bsAbs) that bind to both CD38 and CD28 and act as costimulatory agents to activate T cells via binding CD80 and/or CD86. In certain embodiments, the bispecific antigen-binding molecules of the present invention are capable of inhibiting the growth of tumors expressing CD38. The bispecific antigen-binding molecules of the invention are useful for the treatment of diseases and disorders in which an upregulated or induced CD38-targeted immune response is desired and/or therapeutically beneficial. For example, the bispecific antibodies of the invention are useful for the treatment of various cancers, including multiple myeloma, lymphoma, and leukemia.

Abstract: Provided herein are methods, chemical library and simulation system for performing in situ patterned chemistry. Methods, systems and assays comprising the use of the synthesized chemical libraries, which increase explored protein space in a knowledge-based manner, are also provided for characterizing antibody-target interactions including: identifying target proteins of antibodies, characterizing antibody-binding regions in target proteins, identifying linear and structural epitopes in target proteins, and determining the propensity of antibody binding to target proteins.

Abstract: A device may include a first set of electrodes, a second set of electrodes that is transverse the first set, and at least one connection between an electrode in the first set to an electrode in the second set by a high pass filter. The connected electrode(s) in the first set and the connected electrode(s) in the second set may form an antenna. The device may include a processor and memory. The memory may store programmed instructions which cause the processor, when executed, to transmit a wireless signal using the connected electrodes during a first time, and measure a capacitance signal using electrodes in the first set and electrodes in the second set during a second time.

Abstract: Disclosed is a cyber-security system that is configured to aggregate and unify data from multiple components and platforms on a network. The system allows security administrators to design and implement a workflow of device-actions taken by security individuals in response to a security incident. Based on the nature of a particular threat, the cyber-security system may initiate an action plan that is tailored to the security operations center and their operating procedures to protect potentially impacted components and network resources.

Abstract: A system receives a vehicle transport instruction for transporting a vehicle. The system instructs display of an indicator related to the transport instruction, using a first vehicle output. Further, the system determines whether a vehicle is in a state designated for alert notification based on at least a transportation error detected by the vehicle and changes at least one of the first vehicle output or a second vehicle output to indicate the transportation error responsive to detection of the transportation error by the vehicle.

Abstract: In one example in accordance with the present disclosure, a fluid ejection controller is described. The fluid ejection controller includes a firing board to pass control signals to a fluid ejection device to eject fluid from the fluid ejection device. A mount pivotally holds the firing board between a disengaged position where electrical pins of the firing board are not in contact with electrical pads of the fluid ejection device and an engaged position where the electrical pins are in contact with the electrical pads. The mount includes a slot to receive the fluid ejection device and at least one biasing spring to bias the firing board away from the fluid ejection device during insertion of the fluid ejection device. The fluid ejection controller also includes a handle coupled to a cam shaft to move the firing board between the disengaged position and the engaged position.

Abstract: The present disclosure relates methods for treating skin disorders caused by an immune deficiency with topical formulations comprising ethyl (R)-4-((1-(2-cyanoacetyl)piperidin-3-yl)amino)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate (Compound I) or pharmaceutically acceptable derivative thereof. In particular, the topical formulations described herein may be used to treat atopic dermatitis, alopecia areata, or vitiligo.

Abstract: Aspects of the present disclosure involve a system comprising a computer-readable storage medium storing a program and a method for generating an avatar. The program and method perform operations comprising delivering, by a messaging server, a notification to a client device that identifies a fashion item for customizing an avatar of a user; causing the notification comprising the fashion item to be displayed on the client device; receiving, by the messaging server, a request from the client device to access the fashion item; determining that the request from the client device to access the fashion item has been received prior to expiration of a scarcity parameter of the fashion item; and enabling the client device to access the fashion item in response to determining that the request from the client device has been received prior to the expiration of the scarcity parameter of the fashion item.

Abstract: This invention relates to compositions of matter, methods, modules and instruments for automated mammalian cell growth and mammalian cell transduction followed by nucleic acid-guided nuclease editing in live mammalian cells.

Abstract: A system and method for using a portable device to communicate with a vehicle to authorize one or more vehicle operations. The portable device may authorize the vehicle to unlock/lock doors, start the vehicle engine, or mobilize the vehicle, or a combination thereof. The vehicle may include a vehicle transmitter system with one or more transmitters disposed at various locations on the vehicle, and the portable device may be configured to monitor a communication strength between the portable device and the one or more transmitters of the transmitter system. Based on the monitored signal strength, the portable device may determine location information about itself.

Abstract: This invention is directed to the treatment of cancer, particularly castration-resistant prostate cancer and osteoblastic bone metastases, with a dual inhibitor of MET and VEGF.

Abstract: Methods and systems for implementing a traditional computer vision algorithm as a neural network. The method includes: receiving a definition of the traditional computer vision algorithm that identifies a sequence of one or more traditional computer vision algorithm operations; mapping each of the one or more traditional computer vision algorithm operations to a set of one or more neural network primitives that is mathematically equivalent to that traditional computer vision algorithm operation; linking the one or more network primitives mapped to each traditional computer vision algorithm operation according to the sequence to form a neural network representing the traditional computer vision algorithm; and configuring hardware logic capable of implementing a neural network to implement the neural network that represents the traditional computer vision algorithm.