Abstract: Novel forms of 2-amino-9-[(2R,5R,7R,8S,10R,12aR,14R,15S,15aR,16R)-14-(6-amino-9H-purin-9)-yl)-15,16-difluoro-2,10-dihydroxy-2,10-disulfidooctahydro-12H-5.8-methanofuro[3,2-1][1,3,6,9,11,2,10]pentaoxa-diphosphacyclotetradecin-7-yl]-1,9-dihydro-6H-purin-6-one, which include crystalline salts and hydrates of 2-amino-9)-[(2R,5R,7R,8,S,10R,12aR,14R,15S,15aR,16R)-14-(6-amino-9H-purin-9-yl)-15,16-difluoro-2,10-dihydroxy-2,10-disulfido-octahydro-12H-5,8-methanofuro[3,2-1][1,3,6,9,11,2,10]pentaoxa-diphosphacyclotetradecin-7-yl]-1,9-dihydro-6H-purin-6-one, may be useful as inductors of type I interferon production, specifically as STING active agents.

Abstract: One or more fields can be divided into portions, and different sets of interventions can be performed during the course of planting and growing a crop in each field portion. The effect of each set of interventions on the crop outcome of the corresponding field portion can be determined using a best performing model of a set of predictive models applied to the set of interventions. The selected model can be used to determine an effect of each intervention on crop outcome of a field portion by estimating a portion of the crop outcome attributable to the intervention. A machine-learned model can be trained based on the effect each intervention has on crop outcome determined by the selected model, and the machine-learned model can be applied to subsequent fields and crops to predict effects that various interventions can have on subsequent crop outcomes.

Abstract: An oral hygiene composition includes a mixture of: (i) a carrier liquid; and (ii) a water-insoluble hydratable polymer fibers forming an entangled three-dimensional network of said water-insoluble hydratable polymer fibers in said carrier; wherein: said carrier liquid comprises one or more humectant in a concentration of total humectant in excess of 5 wt. % based on the weight of the composition; said composition has an elastic modulus G? and a loss modulus G?, and said elastic modulus G? is larger that said loss modulus G?; and said water-insoluble hydratable polymer fibers have a diameter of about 10 to about 20,000 nm and a length of at least 100 nm.

Abstract: Process for forming controlled release antimicrobial salts that include a four-part mixture of (i) an antimicrobial cation, (ii) the anion of an organic acid, (iii) an ammonium, sodium or potassium cation and (iv) an anion such as a halide, acetate or gluconate, dissolved in a solvent so that a concentrate with dissociated controlled release antimicrobial ions is formed. Upon addition of water, controlled-release antimicrobial salt having a solubility in water at 20° C. of greater than about 0.001 (w/w) %, but less than about 1 (w/w) % are formed. Alternatively, a controlled release antimicrobial salt is formed in situ at a site of application containing moisture by addition of a concentrate having dissociated controlled release antimicrobial ions.

Abstract: This invention relates to methods and compositions for improving plant health. The present invention includes methods for making an enriched library of treatments capable of improving plant health, methods for an making an enriched library of plants capable of being improved by a treatment, and methods of marketing a plant treatment, as well as synthetic compositions comprising treatments produced by the methods of the present invention, synthetic compositions comprising endophytes capable of improving plant health, and nucleic acid probes and nucleic acid detection kits that may be used in the methods of the present invention.

Abstract: A method for cleaning, benefiting, or deodorizing skin or hair utilizing a body wash, skin cleaner, soap, shampoo or deodorizer formulation containing a controlled release skin benefit or deodorizing salt, a hydrophilic moisturizing polymer and surfactants is described. The method imparts benefits or deodorizing agents to the skin or hair and maintains effective levels for an extended period.

Abstract: A method for cleaning, benefiting, or deodorizing skin or hair utilizing a body wash, skin cleaner, soap, shampoo or deodorizer formulation containing a controlled release skin benefit or deodorizing salt, a hydrophilic moisturizing polymer and surfactants is described. The method imparts benefits or deodorizing agents to the skin or hair and maintains effective levels for an extended period.

Abstract: A method of eliminating, reducing or preventing unwanted pests such as dust mites, fleas, bed bugs, arachnids or insects from fabric articles, comprising contacting the fabric articles with carbon dioxide and/or ammonia gas generated from one or more salts, capable of generating carbon dioxide and/or ammonia gas such as by heat, moisture or reaction with an acid or a base.

Abstract: A dual-compartment dispensing container for retaining and dispensing two separate products or product phases such that each product or product phase is concurrently dispensed from each compartment in substantially equal volumetric amounts. The first compartment comprises a deformable semi-circular inner tube having a top end and a bottom end. The inner tube is disposed within a second compartment comprising a deformable fully circular outer tube having a top end and a bottom end.

Abstract: A dermatological composition for application to the skin or nails comprises a salt of a cation and an anion. The cation is derived from a monomeric or polymeric molecule that will generate an amidine moiety, a guanidine moiety or a biguanide moiety. The anion is derived from a monomeric or polymeric molecule that will generate a carboxylic acid moiety. The composition may be prepared by a metathesis or acid-base reaction.

Abstract: An environmentally friendly, human safe, aqueous-based cleaning composition which can be formulated for cleaning a variety of substrates comprises an alkyl polyglycoside nonionic surfactant, and an alkyl amphocarboxylate surfactant. The composition is free of hydrocarbon solvents, contains a minimal amount of organic polar solvents, and contains naturally derived adjuvants such as chelating agents, fragrances, and buffers.

Abstract: A pseudo-plastic or thixotropic carrier having anti-malodorous components dissolved or suspended therein is sprayed on the internal surfaces of an ostomy bag or pouch. The viscoelastic properties of the carrier allow the composition to be conveniently dispensed from a spray bottle into the ostomy bag and retained on the inner walls thereof without being displaced therefrom by incoming waste during use of the ostomy bag. This allows the composition to continue to deodorize the ostomy bag headspace even after waste material begins to fill the bag.

Abstract: A pseudo-plastic or thixotropic carrier having anti-malodorous components dissolved or suspended therein is sprayed on the internal surfaces of an ostomy bag or pouch. The viscoelastic properties of the carrier allow the composition to be conveniently dispensed from a spray bottle into the ostomy bag and retained on the inner walls thereof without being displaced therefrom by incoming waste during use of the ostomy bag. This allows the composition to continue to deodorize the ostomy bag headspace even after waste material begins to fill the bag.

Abstract: A composition comprising a chlorinating agent; a nearly insoluble di- or tri-valent metal salt which is an oxide, a hydroxide, a carbonate, or mixture thereof; and the composition has a pH of less than about 10.5 when in use.

Abstract: A pseudo-plastic or thixotropic carrier having anti-malodorous components dissolved or suspended therein is sprayed on the internal surfaces of an ostomy bag or pouch. The viscoelastic properties of the carrier allow the composition to be conveniently dispensed from a spray bottle into the ostomy bag and retained on the inner walls thereof without being displaced therefrom by incoming waste during use of the ostomy bag. This allows the composition to continue to deodorize the ostomy bag headspace even after waste material begins to fill the bag.

Abstract: A method of controlling microbial contamination and cross-contamination is disclosed using an (alkali metal or ammonium) (bicarbonate or carbonate) salt contained within a product having an absorbent material with or without a moisture impermeable backing. Where there is no backing, the salt may be impregnated within the absorbent material or may be layered between two plies of absorbent materials.

Abstract: An aqueous alkaline solution comprising at least a caustic and a viscosity stabilizing amount of diutan gum.

Abstract: An aqueous alkaline solution comprising at least a caustic and a viscosity stabilizing amount of diutan gum.

Abstract: An electronic stethoscope having several modes of operation to process acoustic signals to provide filtered signals useful for diagnosis. In one mode of operation the stethoscope substantially provides only acoustic signals generated by biological activity of the heart. In another mode of operation, the acoustic stethoscope substantially provides only acoustic signals generated by biological activity of the lungs. In another mode of operation, the electronic stethoscope disproportionately amplifies abnormal heart sounds and normal heart sounds to enhance diagnosis of heart abnormalities. The electronic stethoscope is operated in a manner similar to a conventional acoustic stethoscope and has similar spectral characteristics, thus allowing a user with acoustic stethoscope experience to easily use the electronic stethoscope.

Abstract: A solid oral product, e.g., chewing gum, lozenge, an edible foodstuff, and the like, which is useful for remineralizing subsurface dental lesions and/or mineralizing exposed dentinal tubules, contains (A) a discrete cationic agglomerate component composed of at least one water-soluble or partially water-soluble calcium salt and a first inert solid carrier, and (B) a discrete anionic agglomerate component composed of at least one water-soluble orthophosphate salt and a second inert solid carrier. The agglomerate nature of the cationic and anionic components keeps these components separate from one another during storage of the product but allows the cationic and anionic salts to be simultaneously released from the product upon mixing of the product with water and/or saliva to form a mixed aqueous solution such that the solution contains both calcium cations released from the calcium salt and orthophosphate anions released by the orthophosphate salt.