Abstract: The present disclosure relates to protein molecules that specifically bind to CD123, which may have at least one humanized or human CD123-binding domain. Such molecules are useful for the treatment of cancer. The protein molecule binding to CD123 may have a second binding domain that binds to another target. In one embodiment, multi-specific polypeptide molecules bind both CD123-expressing cells and the T-cell receptor complex on T-cells to induce target-dependent T-cell cytotoxicity, activation, and proliferation. The disclosure also provides pharmaceutical compositions comprising the CD123-binding polypeptide molecules, nucleic acid molecules encoding these polypeptides and methods of making these molecules.

Abstract: A method of operating an electric induction motor with a variable-speed drive includes determining a voltage level on a DC bus for the drive, and measuring a first magnitude of magnetic flux from a stator of the normally-operating electric motor, determining a normal flux level. The method includes disabling a first output to the drive when the DC bus voltage is less than a first threshold level. The method includes measuring a magnetic flux feedback signal having a phase and second magnitude, estimating a speed of the electric motor, and configuring a second output signal for the drive when the DC bus voltage is greater than a second threshold level. The second output signal matches a signal from the second magnitude and a phase of magnetic flux. The method includes enabling the drive output to restart the electric motor when the magnetic flux is greater than a third threshold value.

Abstract: A method of operating an electric induction motor with a variable-speed drive includes determining a voltage level on a DC bus for the drive, and measuring a first magnitude of magnetic flux from a stator of the normally-operating electric motor, determining a normal flux level. The method includes disabling a first output to the drive when the DC bus voltage is less than a first threshold level. The method includes measuring a magnetic flux feedback signal having a phase and second magnitude, estimating a speed of the electric motor, and configuring a second output signal for the drive when the DC bus voltage is greater than a second threshold level. The second output signal matches a signal from the second magnitude and a phase of magnetic flux. The method includes enabling the drive output to restart the electric motor when the magnetic flux is greater than a third threshold value.

Abstract: An apparatus is provided for controlling operation of an electric motor through use of an additional power storage arrangement connected across the DC busses of a motor drive and controlling the speed of the motor. The additional power storage arrangement includes an additional capacitor arrangement and a rate limiting arrangement in a series circuit relationship with one another.

Abstract: An apparatus is provided for controlling operation of an electric motor through use of an additional power storage arrangement connected across the DC busses of a motor drive and controlling the speed of the motor. The additional power storage arrangement includes an additional capacitor arrangement and a rate limiting arrangement in a series circuit relationship with one another.

Abstract: The present invention is a rotatable work machine that includes a lower frame assembly having a recessed area in which the operator portion of an upper frame assembly and power source are at least partially positioned. Further, a method of manufacturing and assembling the lower frame assembly enables various size configurations for the work machine. The method of manufacturing and assembling the work machine, along with the specific design and positioning of the various components therein, enhances stability, clearance, and operator visibility with reduced costs and complexity.

Abstract: In the operation of work machines of the type having an extensible arm, the maximum reach of the arm for a given work machine is limited by such factors as the vehicle's weight, body size and engine placement. The present invention provides for a work machine arrangement in which a work machine has an engine cooling apparatus mounted to the work machine body such that the engine cooling apparatus's longitudinal axis is oriented substantially parallel to the arm longitudinal axis.

Abstract: The present invention is a rotatable work machine that includes a lower frame assembly having a recessed area in which the operator portion of an upper frame assembly and power source are at least partially positioned. Further, a method of manufacturing and assembling the lower frame assembly enables various size configurations for the work machine. The method of manufacturing and assembling the work machine, along with the specific design and positioning of the various components therein, enhances stability, clearance, and operator visibility with reduced costs and complexity.

Abstract: An anti-rotational pipe coupling system is disclosed having pipe segments with end surfaces in which receptacles are arranged at spaced intervals circumferentially around each pipe. Interference bodies in the form of elongated pins are received within the receptacles of one pipe segment and extend outwardly from the end surface to engage complementary receptacles in another pipe segment arranged in facing engagement. The pins bear against the pipe segment sidewalls within the receptacles to prevent relative rotation of the pipe segments about a longitudinal axis coaxial with them. The pipe segments are received within a tube which uses flexible splines engaging concentrically aligned grooves in the tube and the pipe segments to prevent relative axial movement between the segments.

Abstract: In the operation of work machines of the type having an extensible arm, the maximum reach of the arm for a given work machine is limited by such factors as the vehicle's weight, body size and engine placement. The present invention provides for a work machine arrangement in which a work machine has an engine cooling apparatus mounted to the work machine body such that the engine cooling apparatus's longitudinal axis is oriented substantially parallel to the arm longitudinal axis.

Abstract: A radiator mounting arrangement for a work machine is described. The radiator mounting arrangement includes a work machine having a forward end, a rearward end, and a lateral sidewall interposed between the forward end and the rearward end. The radiator mounting arrangement also includes a radiator having an inner side edge. The inner side edge has an upper end and a lower end. The radiator is secured to the work machine such that (i) the inner side edge of the radiator is positioned adjacent to the lateral sidewall, (ii) the upper end of the inner side edge is positioned a distance D1 from the lateral sidewall, (iii) the lower end of the inner side edge is positioned a distance D2 from the lateral sidewall, and (iv) the distance D1 is greater than the distance D2 so that the inner side edge and the lateral sidewall define an angle a therebetween.

Abstract: A radiator mounting arrangement for a work machine is described. The radiator mounting arrangement includes a work machine having a forward end, a rearward end, and a lateral sidewall interposed between the forward end and the rearward end. The radiator mounting arrangement also includes a radiator having an inner side edge. The inner side edge has an upper end and a lower end . The radiator is secured to the work machine such that (i) the inner side edge of the radiator is positioned adjacent to the lateral sidewall, (ii) the upper end of the inner side edge is positioned a distance D1 from the lateral sidewall, (iii) the lower end of the inner side edge is positioned a distance D2 from the lateral sidewall, and (iv) the distance D1 is greater than the distance D2 so that the inner side edge and the lateral sidewall define an angle &agr; therebetween.

Abstract: A pipe coupling includes tubular body and a retainer having a continuous strap-like base band and a plurality of spring fingers that extend inwardly therefrom into the inner periphery of the body, and which are cammed outwardly by a pipe when inserted into the coupling, the spring fingers then returning to their original position under the stored spring force for them to snap into a groove in the pipe exterior, and thus provide a positive stop preventing withdrawal of the pipe axially of the coupling. The spring fingers have a generally frusto-conical configuration. In an improved embodiment, the retainer is configured as a single continuous strap-like member having a generally rhomboidal cross-sectional configuration at substantially all cross-sections therearound, and is devoid of the spring fingers and base retainer portion disclosed in the previous embodiments.