Abstract: Offloading the reordering of data between a first predefined order and a second predefined order by causing a secondary processor to perform an operation that was originally intended for another function, such as rendering a geometric shape. Pixels of image data are thus reordered from pixilated little endian order to big endian order with standardized textured draw operations performed by a graphics coprocessor. Preferably, only data that changed from a previous processing cycle are reordered. Subdivisions of the data are determined as a function of a predefined datum size. Further subsets of each subdivision can also be determined with a predefined mask, so that reordering can be applied to multiple subsets at a time. Coordinates of each subdivision are used as input to the secondary processor operation, which transforms the position of each datum so as to reorder the data between the first predefined order and the second predefined order.

Abstract: The invention provides formulations and structural modifications for phenothiazine compounds which result in altered biodistributions, thereby reducing the occurrence of adverse reactions associated with this class of drug.

Abstract: The invention features a method for treating a patient having a cancer or other neoplasm by administering to the patient two compounds simultaneously or within 14 days of each other in amounts sufficient to treat the patient.

Abstract: Embodiments of the invention are directed toward methods and devices for constructing assay arrays including a combination of constituent compositions from constituent arrays. The combined compositions are evaluated, in some embodiments of the invention, to identify combinations with a combination effect. Other embodiments of the invention are directed toward constructing constituent arrays in various configurations to facilitate the production of assay arrays. Such embodiments include: constructing constituent arrays and assay arrays with corresponding composition and assay control sets; constructing constituent arrays with a unique set of origin locations and corresponding sets of derivative locations; varying the concentrations utilized for a constituent composition; and composing assay arrays corresponding to a virtual sparse assay array. Other embodiments of the invention are directed towards systems and method of evaluating the activity of combined compositions in an assay array.

Abstract: Embodiments of the invention are directed toward methods and devices for constructing assay arrays including a combination of constituent compositions from constituent arrays. The combined compositions are evaluated, in some embodiments of the invention, to identify combinations with a combination effect. Other embodiments of the invention are directed toward constructing constituent arrays in various configurations to facilitate the production of assay arrays. Such embodiments include: constructing constituent arrays and assay arrays with corresponding composition and assay control sets; constructing constituent arrays with a unique set of origin locations and corresponding sets of derivative locations; varying the concentrations utilized for a constituent composition; and composing assay arrays corresponding to a virtual sparse assay array. Other embodiments of the invention are directed towards systems and method of evaluating the activity of combined compositions in an assay array.

Abstract: The invention features a method for treating a patient having a cancer or other neoplasm by administering to the patient two compounds simultaneously or within 14 days of each other in amounts sufficient to treat the patient.

Abstract: The invention features a method for treating a patient having a cancer or other neoplasm, by administering to the patient (i) a benzimidazole or a metabolite or analog thereof; and (ii) pentamidine or a metabolite or analog thereof simultaneously or within 14 days of each other in amounts sufficient to inhibit the growth of the neoplasm.

Abstract: The invention features a method for treating a patient having a cancer or other neoplasm, by administering to the patient (i) a benzimidazole or a metabolite or analog thereof; and (ii) pentamidine or a metabolite or analog thereof simultaneously or within 14 days of each other in amounts sufficient to inhibit the growth of the neoplasm.

Abstract: A method of synchronizing a crankshaft signal with the stroke cycle of a four-stroke internal combustion engine induces misfiring in a specified engine cylinder, and uses an assumed synchronization to identify the misfiring cylinder. The crankshaft signal is used to identify reference angular positions of the crankshaft intermediate top dead center positions of consecutive cylinders of the engine firing order, and a time difference between successive reference positions is determined. When the assumed synchronization is such that the current rotation of the crankshaft includes the cylinder in which misfiring is induced, the determined time difference is accumulated in a first accumulator; otherwise, the determined time difference is accumulated in a second accumulator. The presence of misfiring causes the two accumulators to diverge in value, and the direction of such divergence is used to determine if the assumed synchronization is correct or incorrect.

Abstract: The invention features a method for treating a patient having a cancer or other neoplasm by administering to the patient two compounds simultaneously or within 14 days of each other in amounts sufficient to treat the patient.

Abstract: The invention features a method for treating a patient having an immunoinflammatory disorder, by administering to the patient (i) a tetra-substituted pyrimidopyrimidine, and (ii) a corticosteroid simultaneously or within 14 days of each other in amounts sufficient to reduce or inhibit immunoinflammation.

Abstract: The invention features a method for treating a patient having a cancer or other neoplasm, by administering to the patient (i) chlorpromazine or a metabolite or analog thereof; and (ii) pentamidine or a metabolite or analog thereof simultaneously or within 14 days of each other in amounts sufficient to inhibit the growth of the neoplasm.

Abstract: The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis.

Abstract: A method of synchronizing a crankshaft signal with the stroke cycle of a four-stroke internal combustion engine induces misfiring in a specified engine cylinder, and uses an assumed synchronization to identify the misfiring cylinder. The crankshaft signal is used to identify reference angular positions of the crankshaft intermediate top dead center positions of consecutive cylinders of the engine firing order, and a time difference between successive reference positions is determined. When the assumed synchronization is such that the current rotation of the crankshaft includes the cylinder in which misfiring is induced, the determined time difference is accumulated in a first accumulator; otherwise, the determined time difference is accumulated in a second accumulator. The presence of misfiring causes the two accumulators to diverge in value, and the direction of such divergence is used to determine if the assumed synchronization is correct or incorrect.

Abstract: The invention features a method for treating a patient having a cancer or other neoplasm, by administering to the patient (i) a benzimidazole or a metabolite or analog thereof; and (ii) pentamidine or a metabolite or analog thereof simultaneously or within 14 days of each other in amounts sufficient to inhibit the growth of the neoplasm.

Abstract: The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis.

Abstract: An optical illumination assembly comprising an array of optical microprisms and microlenses for redirecting light from a light source. Such displays are used in a wide variety of applications such as backlit flat panel displays requiring a directed light source which provides an efficient output of light. The illumination assembly has a light transmitter optically coupled to an input end of array of microprisms through an optional diffuser, and a microlens on the light output end of each microprism. The microprisms have a light input end optically coupled to the light transmitting means and a light output end spaced from the light input end.

Abstract: The present invention is directed to a computer system for administering employee benefits. The computer system comprises a first tier. The first tier includes a plurality of users. At least one user is a workstation having a processor and memory. At least one other user is a system processing means. The workstation is configured for inputting rules into the computer system. The rules are for controlling the computer system. The system processing means is configured to generate and execute transactions based upon the rules. A second tier includes memory configured to store the rules. The rules are organized into tables within the memory of the second tier. A third tier includes memory configured to store benefit data. The benefit data is organized into tables in the third tier memory. The benefit data can be manipulated only by the system processing means executing the rule-based transactions.

Abstract: The invention features a method of screening two-entity or higher order combinations for biological activity using combinational arrays. The method includes the steps of: (a) providing the entities, (b) creating an array of combinations of entities, (c) providing a test element that includes one or more distinct biological moieties, (d) contacting the array of combinations of entities with the test element under conditions that ensure that each entity/test element contacting is segregated from the others, (e) detecting or measuring a property of the test element, and (f) identifying combinations of entities that cause an effect on the property of the test element that is different from the effect of an entity of the combination by itself.

Abstract: The invention features a method of screening two-entity or higher order combinations for biological activity using combinational arrays. The method includes the steps of: (a) providing the entities, (b) creating an array of combinations of entities, (c) providing a test element that includes one or more distinct biological moieties, (d) contacting the array of combinations of entities with the test element under conditions that ensure that each entity/test element contacting is segregated from the others, (e) detecting or measuring a property of the test element, and (f) identifying combinations of entities that cause an effect on the property of the test element that is different from the effect of an entity of the combination by itself.