Abstract: Therapeutic methods of treating chronic lymphocytic leukemia (CLL) and small lymphocytic leukemia (SLL) are described. In certain embodiments, the invention includes therapeutic methods of treating CLL and SLL using a BTK inhibitor. In certain embodiments, the invention includes therapeutic methods of treating subtypes of CLL and SLL using a BTK inhibitor, including subtypes of CLL in patients sensitive to thrombosis and subtypes of CLL that increase monocytes and NK cells in peripheral blood after treatment with a BTK inhibitor. In certain embodiments, the invention includes therapeutic methods of treating CLL and SLL using a combination of a BTK inhibitor and an anti-CD20 antibody.

Abstract: An antimicrobial switch panel (ASP) system/method allowing for retrofit of existing switch panels with protective antimicrobial covers for toggle switch levers is disclosed. The disclosed system incorporates a toggle switch cover (TSC) formed from a plastic molded extrusion (PME) that is impregnated with an antimicrobial compound (AMC). The PME includes an outer tactile surface (OTS) and an inner capture recess (ICR). The ICR is configured to conform to the outer surface of a toggle switch (TSW) toggle switch lever (TSL) and includes one or surfaces more configured with protrusions and/or indentations that affect mechanical coupling between the TSL and the PME when the ICR is mated with the TSL. The OTS may be configured with a variety of tactile configurations that identify the function of the TSW and/or include a PME colorant that identifies the function of the TSW and/or provide for photoluminescent operation of the PME.

Abstract: A system for controlling blade clearances within a gas turbine engine includes a rotor disk and a rotor blade coupled to the rotor disk. Additionally, the system includes an outer turbine component positioned outward of the rotor blade such that a clearance is defined between the rotor blade and the outer turbine component. Furthermore, the system includes a heat exchanger configured to receive a flow of cooling air bled from the gas turbine engine and transfer heat from the received flow of the cooling air to a flow of coolant to generate cooled cooling air. Moreover, the system includes a valve configured to control the flow of the coolant to the heat exchanger. In this respect, the cooled cooling air is supplied to at least one of the rotor disk or the rotor blade to adjust the clearance between the rotor blade and the outer turbine component.

Abstract: A method of rendering a virtual environment is disclosed. First application data is received. The first application data includes first graph data. The first graph data corresponds to a first state of an application. Second application data is received after the first application data. The second application data corresponds to a second state of the application. The first application data and the second application data are analyzed to determine a change in the first graph data associated with the second application data. An island subgraph within the first graph data that includes the change is determined. Second graph data is generated for the second state. The generating of the second graph data includes partially reconstructing the first graph data. The partial reconstructing includes rebuilding the determined island subgraph. The generated second graph data is communicated for rendering of the virtual environment in the second state.

Abstract: A method of rendering a virtual environment is disclosed. First application data is received. The first application data includes first graph data. The first graph data corresponds to a first state of an application. Second application data is received after the first application data. The second application data corresponds to a second state of the application. The first application data and the second application data are analyzed to determine a change in the first graph data associated with the second application data. An island subgraph within the first graph data that includes the change is determined. Second graph data is generated for the second state. The generating of the second graph data includes partially reconstructing the first graph data. The partial reconstructing includes rebuilding the determined island subgraph. The generated second graph data is communicated for rendering of the virtual environment in the second state.

Abstract: A gas turbine engine including: a fan assembly comprising a fan; and a turbomachine drivingly coupled to the fan and including a compressor section, a combustion section, and a turbine section arranged in serial flow order and defining in part a working gas flowpath, the gas turbine engine defining a bypass passage over the turbomachine; the turbomachine further including a heat exchanger and defining an annular cooling passage extending between an inlet and an outlet, the inlet in airflow communication with the working gas flowpath at a location upstream of the compressor section and the outlet in airflow communication with the bypass passage, the heat exchanger in thermal communication with an airflow through the cooling passage.

Abstract: A faucet handle assembly includes a mounting shank configured to be mounted to a mounting deck. A valve assembly is received within an internal chamber of the mounting shank, and the valve assembly includes a valve stem that is rotatable about a rotation axis to facilitate water flow through the valve assembly. The valve assembly further includes a valve stem adapter that is operably coupled to the valve stem. The faucet handle assembly further includes an upper handle. The upper handle includes a lever that is coupled to the valve stem adapter and the valve stem, and the lever is disposed on a first side of the rotation axis. The upper handle further includes a cover that is coupled to the valve stem adapter and disposed on an opposite second side of the rotation axis. The cover and the lever together obscure the valve stem adapter.

Abstract: A faucet handle assembly configured to properly align a faucet handle relative to a valve assembly. A handle bushing includes an alignment rib received within an alignment slot of the faucet handle. The handle and the handle bushing are operably coupled together by engagement of a flexible tab of the handle bushing with an inner surface of the handle.

Abstract: An automated laboratory system includes a storage system including a frame and a platform slidably mounted to the frame such that the platform is slidable relative to the frame between a docked position and an undocked position, the platform being configured to carry an instrument. The system also includes a robotic device proximate the storage system and being configured to access the instrument carried by the platform. Another automated laboratory system includes a storage system including a table and a tabletop having a central axis and being rotatably positioned on the table such that the tabletop is rotatable about the central axis between a docked position and an undocked position, the tabletop being configured to carry an instrument. The system also includes a robotic device proximate the storage system and being configured to access the instrument carried by the tabletop.

Abstract: A network element is described herein. The network element comprises an embedded device having a processor; a communication device; a first memory having a first firmware; and a second memory having a boot data, a first system partition, a second system partition, a download partition, and a data partition, the second memory storing a software application having software components and a processing sequence comprising first computer-executable instructions that when executed by the processor cause the processor to: store an update package in the download partition, the update package comprising second computer-executable instructions and a firmware package having a firmware update; install the update package to the second system partition; update the first firmware with the firmware update; reload the first firmware; mark the second system partition as an active partition; and reboot into the active partition.

Abstract: A storage assembly includes top and bottom walls, a pair of end walls extending between the top and bottom walls and cooperating with the top and bottom walls to define an interior space, and at least one end surface configured to closely interfit with at least one end surface of an adjacent storage assembly that is substantially similar to the storage assembly at a predefined angular orientation such that a longitudinal axis of the storage assembly is angularly offset from a longitudinal axis of the adjacent storage assembly when the at least one end surface of the storage assembly is interfit with the at least one surface of the adjacent storage assembly The storage assembly may also include a pair of interior walls and a handle relief extending into the top wall and/or a frame assembly located between one of the end walls and one of the interior walls.

Abstract: An oven comprising a housing, a cook cavity located within the housing, wherein the housing includes an opening to the cook cavity and the cook cavity is configured to receive a food item through the opening, an oven door for covering the opening, a heating element configured to heat an air within the cook cavity, an active vent interconnecting the cook cavity and an outside of the housing, and a controller operatively coupled to the active vent and the heating element is disclosed. The controller is configured to perform the steps of (a) turning on the heating element to initiate a cooking cycle, (b) keeping the active vent closed during an initial stage of the cooking cycle, (c) after the initial stage of the cooking cycle, opening the active vent, and (d) keeping the active vent open during at least a portion of a remainder of the cooking cycle.

Abstract: A showerhead assembly including a first fluid dispensing unit including a plurality of first fluidic devices, and a second fluid dispensing unit removably coupled to the first fluid dispensing unit and including a plurality of second fluidic devices. The first fluidic devices and the second fluidic devices each provide a multi-dimensional spray pattern.

Abstract: Disclosed herein are exemplary embodiments of omnidirectional antenna assemblies including broadband monopole antennas. In exemplary embodiments, the antenna assembly includes a broadband monopole antenna comprising stamped and folded elements. The antenna assembly is configured to be operable with high omnidirectional pattern conformity, e.g., at frequencies from about 617 megahertz (MHz) to about 7125 MHz or frequencies from about 698 megahertz (MHz) to about 7125 MHz, etc.

Abstract: A faucet spout includes an arm extending from an upstream portion to a downstream portion. The arm defines a longitudinal axis extending between the upstream portion and the downstream portion. A passageway is disposed in the arm, and the passageway is configured to receive water from a water source. A plurality of baffles is disposed in the passageway. The plurality of baffles defines a tortuous flow path in the passageway. An outlet is disposed substantially perpendicularly to the longitudinal axis. The outlet is configured to receive water from the passageway and deliver water from the faucet spout.

Abstract: Systems and techniques for profiling asset acquisition agent are described herein. A target profile may be obtained. A set of profile attributes may be determined for the target profile. An acquisition target pool may be identified using the set of profile attributes. An acquisition matrix data structure may be generated for the acquisition target pool. An asset pool may be generated by acquiring equity of the acquisition target pool based on the acquisition matrix data structure.