Patents by Inventor Aaldert Rens Molenberg
Aaldert Rens Molenberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 10238775Abstract: Sliceable bone repair material is a porous block-shaped scaffold containing a hydrogel, wherein the hydrogel is formed by Michael type addition of at least two precursor molecules. Said scaffold is made of a synthetic ceramic material and has interconnected macropores having a diameter above 100 ?m. In addition said scaffold has a total porosity of 60 to 80%. The total volume of the hydrogel is smaller than the total volume of the interconnected macropores.Type: GrantFiled: March 31, 2017Date of Patent: March 26, 2019Assignee: STRAUMANN HOLDING AGInventors: Corinna Mauth, Aaldert-Rens Molenberg
-
Patent number: 10098983Abstract: Sliceable bone repair material is a porous block-shaped scaffold containing a hydrogel, wherein the hydrogel is formed by Michael type addition of at least two precursor molecules. Said scaffold is made of a synthetic ceramic material and has interconnected macropores having a diameter above 100 ?m. In addition said scaffold has a total porosity of 80 to 95%. The total volume of the hydrogel is smaller than the total volume of the interconnected macropores.Type: GrantFiled: March 31, 2017Date of Patent: October 16, 2018Assignees: STRAUMANN HOLDING AG, CAM BIOCERAMICS B.V.Inventors: Corinna Mauth, Aaldert-Rens Molenberg
-
Publication number: 20170203000Abstract: Sliceable bone repair material is a porous block-shaped scaffold containing a hydrogel, wherein the hydrogel is formed by Michael type addition of at least two precursor molecules. Said scaffold is made of a synthetic ceramic material and has interconnected macropores having a diameter above 100 ?m. In addition said scaffold has a total porosity of 80 to 95%. The total volume of the hydrogel is smaller than the total volume of the interconnected macropores.Type: ApplicationFiled: March 31, 2017Publication date: July 20, 2017Applicants: STRAUMANN HOLDING AG, CAM BIOCERAMICS B.V.Inventors: Corinna MAUTH, Aaldert-Rens MOLENBERG
-
Publication number: 20170203008Abstract: Sliceable bone repair material is a porous block-shaped scaffold containing a hydrogel, wherein the hydrogel is formed by Michael type addition of at least two precursor molecules. Said scaffold is made of a synthetic ceramic material and has interconnected macropores having a diameter above 100 ?m. In addition said scaffold has a total porosity of 60 to 80%. The total volume of the hydrogel is smaller than the total volume of the interconnected macropores.Type: ApplicationFiled: March 31, 2017Publication date: July 20, 2017Applicant: STRAUMANN HOLDING AGInventors: Corinna MAUTH, Aaldert-Rens MOLENBERG
-
Publication number: 20150032221Abstract: Sliceable bone repair material is a porous block-shaped scaffold containing a hydrogel, wherein the hydrogel is formed by Michael type addition of at least two precursor molecules. Said scaffold is made of a synthetic ceramic material and has interconnected macropores having a diameter above 100 ?m. In addition said scaffold has a total porosity of 80 to 95%. The total volume of the hydrogel is smaller than the total volume of the interconnected macropores.Type: ApplicationFiled: February 12, 2013Publication date: January 29, 2015Inventors: Corinna Mauth, Aaldert-Rens Molenberg
-
Publication number: 20150025651Abstract: Sliceable bone repair material is a porous block-shaped scaffold containing a hydrogel, wherein the hydrogel is formed by Michael type addition of at least two precursor molecules. Said scaffold is made of a synthetic ceramic material and has interconnected macropores having a diameter above 100 ?m. In addition said scaffold has a total porosity of 60 to 80%. The total volume of the hydrogel is smaller than the total volume of the interconnected macropores.Type: ApplicationFiled: February 12, 2013Publication date: January 22, 2015Inventors: Corinna Mauth, Aaldert-Rens Molenberg
-
Patent number: 8574611Abstract: The present invention relates to a sliceable composite bone repair material comprising a porous block-shaped ceramic scaffold and a stabilizing polymer disposed therein. Said ceramic scaffold is a synthetic ceramic material or a naturally-derived material. Additionally said scaffold comprises interconnected macropores.Type: GrantFiled: June 30, 2008Date of Patent: November 5, 2013Assignee: Straumann Holding AGInventors: Reinhart Seibl, Aaldert Rens Molenberg, Astrid Sylvia Neidhardt, Nienke Beuling
-
Patent number: 8282912Abstract: Methods for making biomaterials for augmentation of soft and hard tissues, kits containing precursors for forming the biomaterials, and the resulting biomaterials are described herein. The biomaterials are formed from at least a first and a second precursor component. The first precursor component contains at least two nucleophilic groups, and the second precursor component contains at least two electrophilic groups. The nucleophilic and electrophilic groups of the first and second precursor components form covalent linkages with each other at physiological temperatures. The precursors are selected based on the desired properties of the biomaterial. In the preferred embodiment, the first precursor is a siloxane. Optionally, the biomaterials contain additives, such as thixotropic agents, radiopaque agents, or bioactive agents. In the preferred embodiment, the biomaterials are used to augment at least one vertebra of the spine (vertebroplasty).Type: GrantFiled: July 10, 2009Date of Patent: October 9, 2012Assignee: Kuros Biosurgery, AGInventors: Aaldert Rens Molenberg, Enrico Zamparo, Laurent Rapillard, Simona Cerritelli
-
Patent number: 8044172Abstract: Cell-occlusive membrane, obtainable by reaction of at least two precursors in the presence of water. The first precursor A comprises a core and n chains each having a conjugated unsaturated group or a conjugated unsaturated bond, and the second precursor B comprises a core and m chains each having a thiol group, wherein m is greater than or equal to 2, n is greater than or equal to 2, and m+n is greater than or equal to 5. The reaction forms a three dimensional network with crosslinking-points. The adjacent crosslinking-points are connected by a chain having less than 600 atoms.Type: GrantFiled: October 15, 2009Date of Patent: October 25, 2011Assignee: Straumann Holding AGInventor: Aaldert Rens Molenberg
-
Publication number: 20100292146Abstract: The present invention relates to a sliceable composite bone repair material comprising a porous block-shaped ceramic scaffold and a stabilizing polymer disposed therein. Said ceramic scaffold is a synthetic ceramic material or a naturally-derived material. Additionally said scaffold comprises interconnected macropores.Type: ApplicationFiled: June 30, 2008Publication date: November 18, 2010Applicants: Straumann Holding AG, CAM Implants B.V.Inventors: Reinhart Seibl, Aaldert Rens Molenberg, Astrid Sylvia Neidhardt, Nienke Beuling
-
Patent number: 7741427Abstract: The present invention relates to a cell-occlusive membrane, obtainable by reaction of at least two precursors in the presence of water. The first precursor A comprises a core and n chains each having a conjugated unsaturated group or a conjugated unsaturated bond, and the second precursor B comprises a core and m chains each having a thiol group, wherein m is greater than or equal to 2, n is greater than or equal to 2, and m+n is greater than or equal 5. The reaction forms a three dimensional network with crosslinking-points. The adjacent crosslinking-points are connected by a chain having less than 600 atoms.Type: GrantFiled: May 9, 2005Date of Patent: June 22, 2010Assignee: Straumann Holding AGInventor: Aaldert Rens Molenberg
-
Publication number: 20100105800Abstract: Cell-occlusive membrane, obtainable by reaction of at least two precursors in the presence of water. The first precursor A comprises a core and n chains each having a conjugated unsaturated group or a conjugated unsaturated bond, and the second precursor B comprises a core and m chains each having a thiol group, wherein m is greater than or equal to 2, n is greater than or equal to 2, and m+n is greater than or equal to 5. The reaction forms a three dimensional network with crosslinking-points. The adjacent crosslinking-points are connected by a chain having less than 600 atoms.Type: ApplicationFiled: October 15, 2009Publication date: April 29, 2010Applicant: Straumann Holding AGInventor: Aaldert Rens Molenberg
-
Publication number: 20100034769Abstract: Methods for making biomaterials for augmentation of soft and hard tissues, kits containing precursors for forming the biomaterials, and the resulting biomaterials are described herein. The biomaterials are formed from at least a first and a second precursor component. The first precursor component contains at least two nucleophilic groups, and the second precursor component contains at least two electrophilic groups. The nucleophilic and electrophilic groups of the first and second precursor components form covalent linkages with each other at physiological temperatures. The precursors are selected based on the desired properties of the biomaterial. In the preferred embodiment, the first precursor is a siloxane. Optionally, the biomaterials contain additives, such as thixotropic agents, radiopaque agents, or bioactive agents. In the preferred embodiment, the biomaterials are used to augment at least one vertebra of the spine (vertebroplasty).Type: ApplicationFiled: July 10, 2009Publication date: February 11, 2010Inventors: Aaldert Rens Molenberg, Enrico Zamparo, Laurent Rapillard, Simona Cerritelli
-
Patent number: 7575740Abstract: Methods for making biomaterials for augmentation of soft and hard tissues, kits containing precursors for forming the biomaterials, and the resulting biomaterials are described herein. The biomaterials are formed from at least a first and a second precursor component. The first precursor component contains at least two nucleophilic groups, and the second precursor component contains at least two electrophilic groups. The nucleophilic and electrophilic groups of the first and second precursor components form covalent linkages with each other at physiological temperatures. The precursors are selected based on the desired properties of the biomaterial. In the preferred embodiment, the first precursor is a siloxane. Optionally, the biomaterials contain additives, such as thixotropic agents, radiopaque agents, or bioactive agents. In the preferred embodiment, the biomaterials are used to augment at least one vertebra of the spine (vertebroplasty).Type: GrantFiled: March 21, 2003Date of Patent: August 18, 2009Assignee: Kuros Biosurgery AGInventors: Aaldert Rens Molenberg, Daniel Fehr, Enrico Zamparo
-
Patent number: 7566754Abstract: The invention relates to novel crosslinkable copolymers which are obtainable by (a) copolymerizing at least one hydrophilic monomer having one ethylenically unsaturated double bond and at least one crosslinker comprising two or more ethylenically unsaturated double bonds in the presence of a chain transfer agent having a functional group; and (b) reacting one or more functional groups of the resulting copolymer with an organic compound having an ethylenically unsaturated group. The crosslinkable copolymers of the invention are especially useful for the manufacture of biomedical mouldings, for example ophthalmic mouldings such as in particular contact lenses.Type: GrantFiled: August 10, 2007Date of Patent: July 28, 2009Assignee: Novartis AGInventors: Beat Müller, Alain Laurent, Veerle Coessens, Aaldert Rens Molenberg
-
Patent number: 7268189Abstract: The invention relates to novel crosslinkable copolymers which are obtainable by (a) copolymerizing at least one hydrophilic monomer having one ethylenically unsaturated double bond and at least one crosslinker comprising two or more ethylenically unsaturated double bonds in the presence of a chain transfer agent having a functional group; and (b) reacting one or more functional groups of the resulting copolymer with an organic compound having an ethylenically unsaturated group. The crosslinkable copolymers of the invention are especially useful for the manufacture of biomedical mouldings, for example ophthalmic mouldings such as in particular contact lenses.Type: GrantFiled: March 21, 2006Date of Patent: September 11, 2007Assignee: Novartis AGInventors: Beat Müller, Alain Laurent, Veerle Coessens, Aaldert Rens Molenberg
-
Patent number: 7238750Abstract: The invention relates to novel crosslinkable copolymers which are obtainable by (a) copolymerizing at least one hydrophilic monomer having one ethylenically unsaturated double bond and at least one crosslinker comprising two or more ethylenically unsaturated double bonds in the presence of a chain transfer agent having a functional group; and (b) reacting one or more functional groups of the resulting copolymer with an organic compound having an ethylenically unsaturated group. The crosslinkable copolymers of the invention are especially useful for the manufacture of biomedical mouldings, for example ophthalmic mouldings such as in particular contact lenses.Type: GrantFiled: June 14, 2006Date of Patent: July 3, 2007Assignee: Novartis AGInventors: Beat Müller, Alain Laurent, Veerle Coessens, Aaldert Rens Molenberg
-
Patent number: 7091283Abstract: The invention relates to novel crosslinkable copolymers which are obtainable by (a) copolymerizing at least one hydrophilic monomer having one ethylenically unsaturated double bond and at least one crosslinker comprising two or more ethylenically unsaturated double bonds in the presence of a chain transfer agent having a functional group; and (b) reacting one or more functional groups of the resulting copolymer with an organic compound having an ethylenically unsaturated group. The crosslinkable copolymers of the invention are especially useful for the manufacture of biomedical mouldings, for example ophthalmic mouldings such as in particular contact lenses.Type: GrantFiled: March 23, 2001Date of Patent: August 15, 2006Assignee: Novartis AGInventors: Beat Müller, Alain Laurent, Veerle Coessens, Aaldert Rens Molenberg
-
Publication number: 20030232944Abstract: Methods for making biomaterials for augmentation of soft and hard tissues, kits containing precursors for forming the biomaterials, and the resulting biomaterials are described herein. The biomaterials are formed from at least a first and a second precursor component. The first precursor component contains at least two nucleophilic groups, and the second precursor component contains at least two electrophilic groups. The nucleophilic and electrophilic groups of the first and second precursor components form covalent linkages with each other at physiological temperatures. The precursors are selected based on the desired properties of the biomaterial. In the preferred embodiment, the first precursor is a siloxane. Optionally, the biomaterials contain additives, such as thixotropic agents, radiopaque agents, or bioactive agents. In the preferred embodiment, the biomaterials are used to augment at least one vertebra of the spine (vertebroplasty).Type: ApplicationFiled: March 21, 2003Publication date: December 18, 2003Applicants: Kuros Biosurgery AG, Straumann Biologics AGInventors: Aaldert Rens Molenberg, Daniel Fehr, Enrico Zamparo
-
Patent number: 6444776Abstract: The present invention relates to novel crosslinkable amphiphilic block copolymers of formula wherein the variables are as defined in the claims, a process for their preparation and their use for the manufacture of mouldings. The block copolymers of the invention are especially useful for the manufacture of ophthalmic mouldings such as in particular contact lenses.Type: GrantFiled: December 21, 1999Date of Patent: September 3, 2002Assignee: Novartis AGInventors: Troy Vernon Holland, Thomas Hirt, Jacalyn Mary Schremmer, Richard Carlton Baron, Wilson Leonard Terry, Jr., Aaldert Rens Molenberg