Abstract: The invention relates to compounds, methods and compositions for improving on nucleic acid polymerization, including DNA replication by in vitro primer extension to generate, for example, polymers for nanopore-based single molecule sequencing of a DNA template. A nucleic acid polymerase reaction composition is provided with polymerization enhancement moieties, which allows enhanced DNA polymerase activity with nucleotide analogs, resulting in improved length of primer extension products for sequencing applications.

Abstract: A device may receive, from multiple systems, data related to an individual. The device may anonymize, after receiving the data and using an anonymization technique, information included in the data that identifies the individual. The device may apply a formatting to the data after anonymizing the information that identifies the individual. The device may identify, after applying the formatting to the data, historical data related to the individual, to a provider associated with a claim for care, or to historical claims, and population data associated with demographics of the individual. The device may process, in association with identifying the historical data and the population data, the data using a machine learning model. The machine learning model may be associated with generating a prediction related to the individual or the care provided to the individual. The device may perform one or more actions based on the prediction.