Abstract: Enhanced metering systems for managing dosing aliquots feature cartridge housings for exchangeable cartridge with plugs for housing functional substances, extruding conduit tips with fluid flow conduits driven by advancing members for driving amounts of metered functional substance throughout the tips. Manual, pneumatic electrical and/or electronic means for advancing, combined with one way valves, viewing slots, multiple metering and dispensing ports enable two cartridge to be metered at once, as shown by graduated scales.