Abstract: The present disclosure provides nucleic acid molecules encoding an engineered antigen receptor, such as a chimeric antigen receptor or exogenous T cell receptor, and an inhibitory nucleic acid molecule, such as an RNA interference molecule. The present disclosure further relates to nucleic acids, DNA constructs, vectors, pharmaceutical compositions, genetically-modified cells, and methods of treatment that utilize the nucleic acid molecules of the invention.

Abstract: The present invention provides compositions and methods for inducing antigen-specific tolerance in a subject. In one embodiment, the present invention provides a composition comprising an apoptotic body and an epitope of an antigen. Also provided herein are methods of preparing and administering the composition. The composition and methods provided herein can induce antigen-specific tolerance in a subject.

Abstract: The present disclosure provides novel co-stimulatory domains useful in genetically-modified cells to promote cell proliferation and/or promote cytokine secretion after antigen recognition. For example, disclosed herein arc genetically-modified cells comprising a chimeric antigen receptor or an inducible regulatory construct incorporating the co-stimulatory domains disclosed herein. Also disclosed herein are plasmids and viral vectors comprising a nucleic acid sequence encoding the co-stimulatory domains, and methods of administering compositions comprising the novel co-stimulatory domains to subjects in order to reduce the symptoms, progression, or occurrence of disease, such as cancer.

Abstract: Aspects of the subject disclosure may include, for example, receiving a request to forecast allocations for a new descriptor, the new descriptor differing from preexisting descriptors, each of the preexisting descriptors being associated with a subset of locations of a network of locations, each location corresponding to an electronic segment in electronic canvases, and the new descriptor being associated with a new subset of locations of the network of locations, identifying one or more affected descriptors having one or more overlapping subsets of locations of the network of locations and one or more non-overlapping subsets of locations of the network of locations, determining a forecast of allocated locations in each of the one or more affected descriptors; identifying, according to the forecast, at least a portion of allocated locations in the one or more overlapping subsets of locations that are displaceable resulting in a number of displaceable allocations, and determining, according to the number of di

Abstract: The present invention utilizes carrier particles to present antigen peptides and proteins to the immune system in such a way as to induce antigen specific tolerance. The carrier particle is designed in order to trigger an immune tolerance effect. The invention is useful for treatment of immune related disorders such as autoimmune disease, transplant rejection and allergic reactions.

Abstract: A vehicle door lock device includes a lock/unlock unit including a lock/unlock mechanism switching whether to transmit a door opening operation to a latch mechanism; and a transmission unit transmitting a lock/unlock operation to the lock/unlock unit. Further, the lock/unlock unit includes a main case housing the lock/unlock mechanism and supporting the latch mechanism, an input member having a rotation shaft passing through the main case, being coupled to the lock/unlock mechanism in the main case, and having an external coupling part outside the main case; and a cover closing an opening of the main case, the transmission unit includes a coupling member coupling a turned member to the external coupling part, and a sub case housing the coupling member, and the external coupling part protrudes from the main case in a vehicle outside direction in a state where the main case is attached to the door.

Abstract: An enhanced incentive management interface is provided wherein a mobile device executes computer-readable program code and is configured to cause the at least one processing device to receive notification information from an incentive management system, wherein the notification information indicates a user's eligibility to acquire an incentive, display the notification information on the at least one display device, receive, from the incentive management system, user-eligible incentives, display a selectable interactive element on the at least one display device, and in response to the user selecting the interactive element, display, on the at least one display device, an acquired incentive, wherein the acquired incentive is one of the user-eligible incentives.

Abstract: The present disclosure provides novel co-stimulatory domains useful in genetically-modified cells to promote cell proliferation and/or promote cytokine secretion after antigen recognition. For example, disclosed herein are genetically-modified cells comprising a chimeric antigen receptor or an inducible regulatory construct incorporating the co-stimulatory domains disclosed herein. Also disclosed herein are plasmids and viral vectors comprising a nucleic acid sequence encoding the co-stimulatory domains, and methods of administering compositions comprising the novel co-stimulatory domains to subjects in order to reduce the symptoms, progression, or occurrence of disease, such as cancer.

Abstract: There are described herein methods and systems for providing an engine computer with a power request having been determined by an aircraft computer. The power request is sent over a communication bus and once it reaches the engine computer, the latency due to the different update rates of the engine computer and the aircraft computer are compensated for.

Abstract: Provide a door latch device allowing a childproof-double-lock mechanism is simplified and the size of the door latch device is miniaturized. While supporting a childproof lever and a double lock lever by a support shaft, coordinating the childproof lever and the double lock lever by an interlocking means and for moving the double lock lever in the direction of a double-lock position in conjunction with the childproof lever and the double lock lever move to the 3rd position from the 2nd position where is a childproof lock position.

Abstract: Disclosed herein are recombinant meganucleases engineered to recognize and cleave a recognition sequence present in the human beta-2 microglobulin gene. The disclosure further relates to the use of such recombinant meganucleases in methods for producing genetically-modified eukaryotic cells, and to a population of genetically-modified T cells having reduced cell-surface expression of beta-2 microglobulin.

Abstract: Techniques are disclosed for advantageously forecasting an inventory of a product having a particular duration (e.g., video content). The technique can include determining the particular configuration (e.g., maximum number of impressions, maximum amount of time permitted) of breaks identified within an impression log. Based on the number of breaks and the configurations of the breaks, the technique can forecast a future inventory of the product. In some implementations, the disclosed technique can identify an amount of a previous break that was not filled with video content. These forecasts can enable product sellers to better communicate with their customers, negotiate supply contracts, price their products, plan for business operations, etc.

Abstract: Described is an apparatus which comprises: a comparator to be clocked by a clock signal to be provided by a clocking circuit, wherein the clocking circuit includes: a voltage controlled delay line having two or more delay cells; a multiplexer coupled to the voltage controlled delay line and operable to configure the clocking circuit as a ring oscillator with the voltage controlled delay line forming at least one delay section of the ring oscillator; and select logic coupled to the multiplexer, the select logic is to receive a signal indicating arrival of an input clock, and is to control the multiplexer according to the indication. Described is also an apparatus which comprises: a data path to receive input data; and a clock path to receive an input clock and to provide a preconditioned clock to the data path when the input clock is absent.

Abstract: Described is an apparatus which comprises: a first feedback loop to generate a control signal for regulating an output voltage provided to a load; and a second feedback loop, separate from the first feedback loop, to receive the control signal from the first feedback loop, the second feedback loop to regulate the output voltage provided to the load.

Abstract: A vehicle door lock device includes a lock/unlock unit including a lock/unlock mechanism switching whether to transmit a door opening operation to a latch mechanism; and a transmission unit transmitting a lock/unlock operation to the lock/unlock unit. Further, the lock/unlock unit includes a main case housing the lock/unlock mechanism and supporting the latch mechanism, an input member having a rotation shaft passing through the main case, being coupled to the lock/unlock mechanism in the main case, and having an external coupling part outside the main case; and a cover closing an opening of the main case, the transmission unit includes a coupling member coupling a turned member to the external coupling part, and a sub case housing the coupling member, and the external coupling part protrudes from the main case in a vehicle outside direction in a state where the main case is attached to the door.

Abstract: Described is an apparatus which comprises: logic to convert output of at least one sensor to a digital sensing signal; a router coupled to the sensor, the router to receive the digital sensing signal and to map into circuit data; and one or more communication interfaces, coupled to the router, to forward circuit data to a circuit endpoint. Described is a method which comprises: providing one or more digital sensing signals from a plurality of sensors; receiving the one or more digital sensing signals; generating packets of data using the one or more digital sensing signals; and providing the packets of data to one or more destinations.

Abstract: Described is an apparatus which comprises: a comparator to be clocked by a clock signal to be provided by a clocking circuit, wherein the clocking circuit includes: a voltage controlled delay line having two or more delay cells; a multiplexer coupled to the voltage controlled delay line and operable to configure the clocking circuit as a ring oscillator with the voltage controlled delay line forming at least one delay section of the ring oscillator; and select logic coupled to the multiplexer, the select logic is to receive a signal indicating arrival of an input clock, and is to control the multiplexer according to the indication. Described is also an apparatus which comprises: a data path to receive input data; and a clock path to receive an input clock and to provide a preconditioned clock to the data path when the input clock is absent.

Abstract: A door latch device having a motor cover for covering a motor and connection parts thereof, wherein the motor cover in a size for covering the motor from a vehicle interior side is formed to a switch member housed in a casing, connection parts of the motor are respectively connected to conductive members of the switch member on a vehicle-exterior-side side face of the motor cover, and the motor 44 and the connection parts thereof are covered with the motor cover.

Abstract: A door latch device which allows shared use of a connector for use in door latch devices equipped with standard electric components and a connector for use in door latch devices equipped with special electric components in addition to the standard electric components, thereby achieving an increase in the efficiency of the work of connecting to an external connector and a reduction in costs. A connector (32) of a standard switch plate (26) has a coupling hole (51) which penetrates, in the connecting direction of the external connector, a portion having no standard connecting terminals (304). The coupling hole (51) can be fitted with another switch plate (46) that allows the passage of electric current through electric components different than the standard electric components.

Abstract: An article that includes a structured substrate having a macro-porous structure that defines a plurality of pores, and a metallic nano-crystalline coating on at least a portion of the structured substrate, where the metallic nano-crystalline coating defines an average grain size less than about 20 nanometers.