Abstract: A hypodermic needle extraction device for removing a hypodermic needle from a syringe having a syringe body and a luer, the device including at least one guide rod disposed with the device, a carriage assembly having a carriage slidably mounted on the guide rod, and a needle extraction assembly configured to grasp the needle such that the needle is separated from the syringe body as the syringe body and needle are urged apart. This Abstract is presented to meet requirements of 37 C.F.R. §1.72(b) only. This Abstract is not intended to identify key elements of the apparatus and methods disclosed herein or to delineate the scope thereof.

Abstract: This invention relates to the use of benzimidazole derivatives for the modulation, notably the inhibition of the activity or function of fatty acid synthase (FAS). Suitably, the present invention relates to the use of benzimidazoles in the treatment of cancer.

Abstract: A hypodermic needle extraction device for removing a hypodermic needle from a syringe having a syringe body and a luer, the device including at least one guide rod disposed with the device, a carriage assembly having a carriage slidably mounted on the guide rod, and a needle extraction assembly configured to grasp the needle such that the needle is separated from the syringe body as the syringe body and needle are urged apart.

Abstract: A hypodermic needle extraction device for removing a hypodermic needle from a syringe having a syringe body and a luer, the device including at least one guide rod disposed with the device, a carriage assembly having a carriage slidably mounted on the guide rod, and a needle extraction assembly configured to grasp the needle such that the needle is separated from the syringe body as the syringe body and needle are urged apart.

Abstract: A dental x-ray sensor holder includes at least two clamping faces wherein at least one of the faces includes at least one and preferably a plurality of resiliently deformable gripping protrusions. The clamping faces are positioned in a moveable, spaced opposing relation, such that the faces may be physically moved together to physically impinge the x-ray sensor therebetween.

Abstract: Catheter-based systems are disclosed for geometrically and temporally controlled deliveries of fluid agents to the heart. Each system includes an elongate catheter shaft, a tissue penetration element at the shaft distal end, and a handle at the shaft proximal end for manipulating the penetrating element. The penetrating element and a proximate conductive coil provide bipolar sensing electrodes. One version of the system includes a fluid lumen through the penetrating element and a contrast fluid lumen open at the catheter shaft distal end. In other versions, the penetrating element contains two fluid lumens. These systems facilitate tissue mapping and therapeutic agent delivery protocols in which several agents can be simultaneously delivered at a depth within heart tissue, prevented from intermingling until they reach the tissue. Treatment and contrast agents can be delivered simultaneously or temporally spaced, directed to the same region or to different regions separated by intervening tissue.

Abstract: A hypodermic needle extraction device for removing a hypodermic needle from a syringe having a syringe body and a luer, the device including at least one guide rod disposed with the device, a carriage assembly having a carriage slidably mounted on the guide rod, and a needle extraction assembly configured to grasp the needle such that the needle is separated from the syringe body as the syringe body and needle are urged apart.

Abstract: A hypodermic needle extraction device for removing a hypodermic needle from a syringe having a syringe body and a luer, the device including at least one guide rod disposed with the device, a carriage assembly having a carriage slidably mounted on the guide rod, and a needle extraction assembly configured to grasp the needle such that the needle is separated from the syringe body as the syringe body and needle are urged apart.

Abstract: A system and method for automatically cloning or migrating a computing appliance while maintaining its operational state. A configuration bundle that includes configuration data, software revision level and a list of system updates is used to recover or duplicate a device's operation state. The system and method can also be utilized to migrate a computing appliance between different operating system while maintaining or replicating the previous operational state.

Abstract: A system and method for automatic disaster recovery and synchronization of computing appliances configured for operation in a cluster. A configuration bundle that includes configuration data, software revision level and a list of system updates is used to recover or duplicate the computing appliance's operation state. Upon entering a clustered configuration, the primary node creates a clustered configuration bundle from individual configuration bundles for the registered nodes in the cluster. The clustered configuration bundle can then be used for disaster recovery or synchronization of any of the registered nodes.

Abstract: A dental x-ray sensor holder includes at least two clamping faces wherein at least one of the faces includes at least one and preferably a plurality of resiliently deformable gripping protrusions. The clamping faces are positioned in a moveable, spaced opposing relation, such that the faces may be physically moved together to physically impinge the x-ray sensor therebetween.

Abstract: The present invention provides devices and associated methods for delivering side-to-side and end-to-side anastomotic connectors to join any two (or more) vessels together such that fluid communication is established between the lumens of the two or more joined vessels. The systems of the present invention employ one or more deployment mechanisms over which the anastomotic connector is positioned for delivery and subsequently deployment within a vessel. The deployment mechanisms may be inflatable balloons or expandable baskets or a combination thereof or the like, which, when inflated and/or expanded, cause one or more portions of the anastomotic connector to deploy.

Abstract: Cycloalkyl ketoamide derivatives, which are useful as cathepsin K inhibitors are described herein. The described invention also includes methods of making such cycloalkyl ketoamide derivatives as well as methods of using the same in the treatment of disorders, including osteoporosis, associated with enhanced bone turnover which can ultimately lead to fracture.

Abstract: The present invention relates to cycloalkylidene compounds with a variety of therapeutic uses, more particularly novel naphthalene compounds that are particularly useful for selective estrogen modulation.

Abstract: The present invention relates to novel compounds with a variety of therapeutic uses, more particularly novel substituted cyclic alkylidene compounds that are particularly useful for selective estrogen receptor modulation.

Abstract: The present invention relates to novel compounds of formula (I) with a variety of therapeutic uses, more particularly novel substituted quinoline compounds particularly useful for selective estrogen receptor modulation.

Abstract: The present invention relates to novel compounds with a variety of therapeutic uses, more particularly novel substituted cyclic alkylidene compounds that are particularly useful for selective estrogen receptor modulation.

Abstract: The present invention includes novel retinoid compounds that have selectivity as RXR agonists on one or more isoforms of RXR, currently, RXR?, RXR?, or RXR?. The present compounds, and pharmaceutical compositions incorporating these compounds, therefore, are effective in treating conditions mediated by RXRs. Among other physiological responses, the compounds of the present invention reduce blood glucose and maintain body weight, and, thus, are useful for the treatment of diabetes (NIDDIM) and obesity.

Abstract: Catheter-based systems are disclosed for geometrically and temporally controlled deliveries of fluid agents to the heart. Each system includes an elongate catheter shaft, a helical, linear or curved tissue penetration element at the distal end of the shaft, and a handle at the proximal end of the shaft for manipulating the penetrating element through the catheter shaft. The penetrating element and a conductive coil near the shaft distal end provide a pair of electrodes for bipolar sensing of tissue electrical activity. One version of the system includes a fluid lumen through the penetrating element and a contrast fluid lumen open at the catheter shaft distal end. In other versions of the catheter system, the penetrating element contains two fluid lumens. These systems facilitate a variety of tissue mapping and therapeutic agent delivery protocols in which several agents can be simultaneously delivered at a depth within heart tissue, prevented from intermingling until they reach the tissue.

Abstract: A polypeptide and methods of using the polypeptide for treating malignancy by administering to a subject a composition of the polypeptide. Pharmaceutical compositions of the polypeptide.