Abstract: A teething spoon may include a feeding end with a concave, textured surface configured to retain soft food and stimulate a tongue, mouth, or gums of a teething toddler; a base having a base diameter at its greatest extent and at least one aperture capable of receiving a removable tether; a handle coupling the feeding end to the base; and a safety guard adjacent the feeding end that extends perpendicularly. The safety guard may have a perpendicular reach of about 50 mm and may include a first loop and second loop opposite and in plane with the first loop. The first and second loops may allow a cylinder of about 10 mm or about 13 mm to pass through unobstructed. The base may comprise a generally hemispherical structure that enables the teething spoon to be disposed vertically. A slot in the base may be configured to accommodate a removable tether.

Abstract: The present invention relates to methods of treating cancer in pediatric subjects comprising administration of compound niraparib in a suitable oral dosage form and optionally in combination with a second therapeutic agent such as a PD-1 inhibitor.

Abstract: In some embodiments, a system comprises a mat body characterized by a front side, a back side and a thickness; a plurality of anchors, each anchor comprising an anchor block having an aperture characterized by an aperture diameter, a suction cup having a sealing surface and an outer surface, and a stem that is coaxial with the suction cup and connects the suction cup to the anchor block. Each anchor may be disposed through the thickness, such that its anchor block is on the front side and its suction cup extends from the back side. The system may further comprise an elongated tether that is removably coupleable to one of the plurality of anchors, and the elongated tether may comprise an anchor end having a generally spherical anchor terminus characterized by an anchor diameter that is greater than the aperture diameter.

Abstract: A hydraulic fracturing and gravel packing proppant composite with protectant on the surface of the proppant and the composition matters of the protectant and proppant. The surface protectant reduces the generation of dust/fines from the proppant caused by abrasion and impingement during transportation and conveyance, particularly pneumatic transfer.

Abstract: In some embodiments, a system comprises a mat body characterized by a front side, a back side and a thickness; a plurality of anchors, each anchor comprising an anchor block having an aperture characterized by an aperture diameter, a suction cup having a sealing surface and an outer surface, and a stem that is coaxial with the suction cup and connects the suction cup to the anchor block. Each anchor may be disposed through the thickness, such that its anchor block is on the front side and its suction cup extends from the back side. The system may further comprise an elongated tether that is removably coupleable to one of the plurality of anchors, and the elongated tether may comprise an anchor end having a generally spherical anchor terminus characterized by an anchor diameter that is greater than the aperture diameter.

Abstract: In some embodiments, a system comprises a mat body characterized by a front side, a back side and a thickness; a plurality of anchors, each anchor comprising an anchor block having an aperture characterized by an aperture diameter, a suction cup having a sealing surface and an outer surface, and a stem that is coaxial with the suction cup and connects the suction cup to the anchor block. Each anchor may be disposed through the thickness, such that its anchor block is on the front side and its suction cup extends from the back side. The system may further comprise an elongated tether that is removably coupleable to one of the plurality of anchors, and the elongated tether may comprise an anchor end having a generally spherical anchor terminus characterized by an anchor diameter that is greater than the aperture diameter.

Abstract: A hydraulic fracturing and gravel packing proppant composite with protectant on the surface of the proppant and the composition matters of the protectant and proppant. The surface protectant reduces the generation of dust/fines from the proppant caused by abrasion and impingement during transportation and conveyance, particularly pneumatic transfer.

Abstract: A system for tensioning a rope of a play structure includes a collar coupled to the play structure. The system includes a tensioner coupled to the rope. The tensioner is coupled to the collar through a threaded connection and where a rotation of the tensioner in relation to the collar adjusts a tension in the rope.

Abstract: In some embodiments, a system comprises a mat body characterized by a front side, a back side and a thickness; a plurality of anchors, each anchor comprising an anchor block having an aperture characterized by an aperture diameter, a suction cup having a sealing surface and an outer surface, and a stem that is coaxial with the suction cup and connects the suction cup to the anchor block. Each anchor may be disposed through the thickness, such that its anchor block is on the front side and its suction cup extends from the back side. The system may further comprise an elongated tether that is removably coupleable to one of the plurality of anchors, and the elongated tether may comprise an anchor end having a generally spherical anchor terminus characterized by an anchor diameter that is greater than the aperture diameter.

Abstract: In some embodiments, a system comprises a mat body characterized by a front side, a back side and a thickness; a plurality of anchors, each anchor comprising an anchor block having an aperture characterized by an aperture diameter, a suction cup having a sealing surface and an outer surface, and a stem that is coaxial with the suction cup and connects the suction cup to the anchor block. Each anchor may be disposed through the thickness, such that its anchor block is on the front side and its suction cup extends from the back side. The system may further comprise an elongated tether that is removably coupleable to one of the plurality of anchors, and the elongated tether may comprise an anchor end having a generally spherical anchor terminus characterized by an anchor diameter that is greater than the aperture diameter.

Abstract: A hydraulic fracturing and gravel packing proppant composite with protectant on the surface of the proppant and the composition matters of the protectant and proppant. The surface protectant reduces the generation of dust/fines from the proppant caused by abrasion and impingement during transportation and conveyance, particularly pneumatic transfer.

Abstract: A comic book case includes a base and a cover configured to compress and secure a comic book in place under frictional pressure such that the book cannot easily shift or slip within the case. Prior art cases that included walls surrounding the top, bottom and side edges of a book typically allowed some free movement or slippage of the book between the walls. This movement or slippage could result in damage such as curling or crinkling of the edges of the book if the case were exposed to a physical shock, such as by being dropped. The base includes a raised base platform and the cover includes a depressed cover platform, which extends towards the base platform to create a space within which the book is securely held.