Abstract: Shape memory yarns described herein include twisted microfilaments made from a shape memory alloy that may provide superelastic or shape memory properties. The shape memory yarns are formed into coils that provide a high degree of actuation or elasticity along an axis of the coiled shape memory yarn, and may have relatively low porosity, low rigidity, and/or low change of volume compared to shape memory coils formed from solid structures. Coiled shape memory yarns may provide further tailorability of a superelastic or shape memory response of a system or device incorporating the coiled shape memory yarns through various coil parameters, such as coil pitch or density, or torque balancing, such as heat treating or plying the coiled shape memory yarns.

Abstract: A method of detecting epithelial cancer is described that includes the steps of: (a) determining the level of beta defensin 3 (BD-3) and beta defensin 2 (BD-2) in a suspect sample obtained from a subject; (b) comparing the level of BD-3 to BD-2 determined in the suspect sample to obtain a suspect BD-3/BD-2 ratio, (c) comparing the suspect BD-3/BD-2 ratio to a healthy BD-3/BD-2 ratio to obtain a diagnostic BD-3/BD-2 ratio; and (d) characterizing the subject as having epithelial cancer if the diagnostic BD-3/BD-2 ratio is greater than 1. A microfluidic device for detecting epithelial cancer using the diagnostic BD-3/BD-2 ratio is also described.

Abstract: A method of detecting epithelial cancer is described that includes the steps of: (a) determining the level of beta defensin 3 (BD-3) and beta defensin 2 (BD-2) in a suspect sample obtained from a subject; (b) comparing the level of BD-3 to BD-2 determined in the suspect sample to obtain a suspect BD-3/BD-2 ratio, (c) comparing the suspect BD-3/BD-2 ratio to a healthy BD-3/BD-2 ratio to obtain a diagnostic BD-3/BD-2 ratio; and (d) characterizing the subject as having epithelial cancer if the diagnostic BD-3/BD-2 ratio is greater than 1. A microfluidic device for detecting epithelial cancer using the diagnostic BD-3/BD-2 ratio is also described.

Abstract: A method of detecting epithelial cancer is described that includes the steps of: (a) determining the level of beta defensin 3 (BD-3) and beta defensin 2 (BD-2) in a suspect sample obtained from a subject; (b) comparing the level of BD-3 to BD-2 determined in the suspect sample to obtain a suspect BD-3/BD-2 ratio, (c) comparing the suspect BD-3/BD-2 ratio to a healthy BD-3/BD-2 ratio to obtain a diagnostic BD-3/BD-2 ratio; and (d) characterizing the subject as having epithelial cancer if the diagnostic BD-3/BD-2 ratio is greater than 1. A microfluidic device for detecting epithelial cancer using the diagnostic BD-3/BD-2 ratio is also described.

Abstract: A method for determining beamforming weights used onboard a satellite and ground-based beamforming weights used in a ground-based station as part of a satellite communication system. This beamforming method is a two-stage beamforming process that requires a reduced downlink bandwidth between the satellite and the ground-based station yet achieves optimal signal-to-noise ratio for bandwidth allocated for the downlink. values for the fixed onboard beamforming weights are computed to yield a maximum, max A ? ( min U ? S N ? ? W = W ? ) , where the maximum is computed over all possible fixed weights A represented by an L×M matrix, the minimum is computed over all possible positions of remote communication devices U, and the signal-to-noise ratio (S/N) is computed for the optimal set of ground-based beamforming weights W={hacek over (W)}.

Abstract: A method of detecting ?-defensin in a bodily sample from a subject includes reducing the electrostatic interaction between ?-defensin and negatively charged moieties in the bodily sample prior to detecting the ?-defensin with an antibody or epitope binding fragment thereof.

Abstract: A method for determining beamforming weights used onboard a satellite and ground-based beamforming weights used in a ground-based station as part of a satellite communication system. This beamforming method is a two-stage beamforming process that requires a reduced downlink bandwidth between the satellite and the ground-based station yet achieves optimal signal-to-noise ratio for bandwidth allocated for the downlink. values for the fixed onboard beamforming weights are computed to yield a maximum, max A ? ( min U ? S N ? ? W = W ? ) , where the maximum is computed over all possible fixed weights A represented by an L×M matrix, the minimum is computed over all possible positions of remote communication devices U, and the signal-to-noise ratio (S/N) is computed for the optimal set of ground-based beamforming weights W={hacek over (W)}.

Abstract: A method for determining beamforming weights used onboard a satellite and ground-based beamforming weights used in a ground-based station as part of a satellite communication system. This beamforming method is a two-stage beamforming process that requires a reduced downlink bandwidth between the satellite and the ground-based station yet achieves optimal signal-to-noise ratio for bandwidth allocated for the downlink. values for the fixed onboard beamforming weights are computed to yield a maximum, max A ? ( min U ? S N ? | W = W ? ) , where the maximum is computed over all possible fixed weights A represented by an L×M matrix, the minimum is computed over all possible positions of remote communication devices U, and the signal-to-noise ratio (S/N) is computed for the optimal set of ground-based beamforming weights W={hacek over (W)}.

Abstract: This application provides, in part, novel polypeptides and nucleic acids that affect induction of defensins, and methods of making and using same.

Abstract: A method of detecting ?-defensin in a bodily sample from a subject includes reducing the electrostatic interaction between ?-defensin and negatively charged moieties in the bodily sample prior to detecting the ?-defensin with an antibody or epitope binding fragment thereof.

Abstract: The disclosure provides, among other things, beta-defensin related agents for the treatment and prevention of viral infections, and particularly HIV infections. The disclosure provides methods for identifying additional beta-defensin related agents and for improving available beta-defensin related agents.

Abstract: A method for determining beamforming weights used onboard a satellite and ground-based beamforming weights used in a ground-based station as part of a satellite communication system. This beamforming method is a two-stage beamforming process that requires a reduced downlink bandwidth between the satellite and the ground-based station yet achieves optimal signal-to-noise ratio for bandwidth allocated for the downlink, values for the fixed onboard beamforming weights are computed to yield a maximum, max A ? ( min U ? S N ? | W = W ? ) , where the maximum is computed over all possible fixed weights A represented by an L×M matrix, the minimum is computed over all possible positions of remote communication devices U, and the signal-to-noise ratio (S/N) is computed for the optimal set of ground-based beamforming weights W={hacek over (W)}.

Abstract: A transceiver employing a steerable phased-array antenna includes a modem architecture in which signals from each antenna element in the array are independently processed down to the individual baseband channel level, and digital beamforming is performed at baseband. The data rate reduction from IF to baseband permits parallel signal data from multiple antenna elements to be time multiplexed and serially processed at acceptable data rates at baseband with minimal modem hardware requirements. Both for transmit signal modulation and received signal demodulation, the computation of carrier tracking, automatic gain control (AGC)/power-control, and beamforming are shared by the same processing circuitry for all channels when performed at baseband. The resulting baseband circuitry is only incrementally larger than that required for carrier tracking and AGC alone, yet accomplishes independent beamforming for each antenna element on each user channel.

Abstract: This application provides, in part, novel polypeptides and nucleic acids that affect induction of defensins, and methods of making and using same.

Abstract: A Spread Spectrum system acquires signals with frequency uncertainty. The present invention independently computes the number of frequency bands necessary to cover the carrier frequency uncertainty and the chip rate uncertainty and uses the largest of the two quantities in the acquisition process. A receiver cycles through pseudonoise code phases until a matched filter output exceeds a threshold. The local code is adjusted based on that code phase and the signal is processed for carrier acquisition, where an FFT estimates the carrier frequency. The code phase and nearest neighbors are used to determine the presence of a false alarm. When a false alarm is absent, the detection is examined for an alias or noise spur. If an alias is absent, the signal search is complete. Otherwise, processing continues to search for a pseudonoise code. The process continues by examining all code phases for each band until a signal is detected.

Abstract: A method for inhibiting the SDF1-CXCR4 signaling pathway in a subject, comprising administering to the subject an effective amount of a Beta Defensin (BD)-inducing agent. The BD-inducing agent may be a Fusobacterium associated defensin inducer (FAD-I) polypeptide or a double stranded RNA analog.

Abstract: A method for inhibiting HIV entry into a cell, or inhibiting HIV infection of a cell, or inhibiting contraction of an HIV infection in a subject comprises administering an effective amount of a Beta Defensin-inducing agent. The Beta Defensin-inducing agent may be a Fusobacterium Associated Defensin Inducer (FAD-I) polypeptide.

Abstract: The disclosure provides, among other things, beta-defensin related agents for the treatment and prevention of viral infections, and particularly HIV infections. The disclosure provides methods for identifying additional beta-defensin related agents and for improving available beta-defensin related agents.

Abstract: The application provides, in part, compositions and methods for the treatment or on of HIV and other viruses associated with certain chemokine receptors.

Abstract: Positioning system for locating a mobile body comprising a plurality of earth based spread spectrum (SS) broadcasting stations arranged geographically in a cellular pattern. Each SS broadcasting station include a modulator providing a channel signal structure which is substantially orthogonal with respect to adjacent stations in the cellular pattern, each channel signal including navigation beacon data including a unique beacon identification, station latitude and longitude, time_slot and phase characterizations and selected parameters of adjacent stations. In one embodiment, each modulator provides a chirped SS signal in which the navigation beacon is a frequency tone that is repeatedly swept over a selected frequency band for each station. In a further embodiment, each modulator provides a GPS like direct sequence SS signal in which the navigation beacon is a PN coded broadcast.